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肥胖与糖尿病前期的关系及发病机制研究进展
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Abstract:
近年来，随着生活方式的改变和饮食结构的调整，糖尿病前期及肥胖症的患病人数呈现出逐年上升的趋势。肥胖作为糖尿病前期的一个重要风险因素，其与糖代谢紊乱之间的关联机制备受关注。本文旨在对肥胖与糖尿病相关的研究进展进行综述，深入探讨肥胖与糖代谢紊乱之间的内在联系，以期为糖尿病前期的早期干预提供理论基础和实践指导。
In recent years, due to alterations in lifestyle and dietary patterns, the prevalence of prediabetes and obesity has exhibited a yearly upward trend. Obesity, as an important risk factor for prediabetes, has attracted much attention for its association with glucose metabolism disorder. The objective of this article is to comprehensively review the research advancements pertaining to obesity and diabetes, while delving into the intricate link between obesity and glucose metabolism dysregulation. This endeavor aims to furnish a theoretical foundation and practical directives for the early intervention of prediabetes.
| [1] | DeJesus, R.S., Breitkopf, C.R., Rutten, L.J., et al. (2017) Incidence Rate of Prediabetes Progression to Diabetes: Modeling an Optimum Target Group for Intervention. Population Health Management, 20, 216-223. https://doi.org/10.1089/pop.2016.0067 |
| [2] | Echouffo-Tcheugui, J.B., Perreault, L., Ji, L., et al. (2023) Diagnosis and Management of Prediabetes: A Review. JAMA, 329, 1206-1216. https://doi.org/10.1001/jama.2023.4063 |
| [3] | (2023) Global, Regional, and National Burden of Diabetes from 1990 to 2021, with Projections of Prevalence to 2050: A Systematic Analysis for the Global Burden of Disease Study 2021. Lancet, 402, 203-234. |
| [4] | Magliano, D.J. and Boyko, E.J. (2021) IDF Diabetes Atlas. International Diabetes Federation, Brussels. |
| [5] | Ruze, R., Liu, T., Zou, X., et al. (2023) Obesity and Type 2 Diabetes Mellitus: Connections in Epidemiology, Pathogenesis, and Treatments. Frontiers in Endocrinology, 14, Article 1161521. https://doi.org/10.3389/fendo.2023.1161521 |
| [6] | Chobot, A., Górowska-Kowolik, K., Soko？owska, M., et al. (2018) Obesity and Diabetes-Not Only a Simple Link between Two Epidemics. Diabetes/Metabolism Research and Reviews, 34, e3042. https://doi.org/10.1002/dmrr.3042 |
| [7] | Wang, L., Gao, P., Zhang, M., et al. (2017) Prevalence and Ethnic Pattern of Diabetes and Prediabetes in China in 2013. JAMA, 317, 2515-2523. https://doi.org/10.1001/jama.2017.7596 |
| [8] | 张毅, 周恍, 张亚辉, 等. 重庆某社区人群10年糖尿病及糖尿病前期患病率的变化趋势[J]. 重庆医科大学学报, 2016, 41(11): 1117-1120. |
| [9] | 鲜圆圆, 高静, 柏丁兮, 等. 中国老年人糖尿病前期患病率的Meta分析[J]. 军事护理, 2022, 39(12): 62-65, 100. |
| [10] | 王洋, 龚燕平. 2019年ESC联合EASD对糖尿病前期、糖尿病、心血管疾病指南的解读[J]. 中国循证心血管医学杂志, 2020, 12(5): 516-518. |
| [11] | Lamparter, J., Raum, P., Pfeiffer, N., et al. (2014) Prevalence and Associations of Diabetic Retinopathy in a Large Cohort of Prediabetic Subjects: The Gutenberg Health Study. Journal of Diabetes and its Complications, 28, 482-487. https://doi.org/10.1016/j.jdiacomp.2014.02.008 |
| [12] | Cundy, T., Holden, A. and Stallworthy, E. (2021) Early Worsening of Diabetic Nephropathy in Type 2 Diabetes after Rapid Improvement in Chronic Severe Hyperglycemia. Diabetes Care, 44, e55-e56. https://doi.org/10.2337/dc20-2646 |
| [13] | Casagrande, S.S., Lee, C., Stoeckel, L.E., et al. (2021) Cognitive Function among Older Adults with Diabetes and Prediabetes, NHANES 2011-2014. Diabetes Research and Clinical Practice, 178, Article ID: 108939. https://doi.org/10.1016/j.diabres.2021.108939 |
| [14] | Shen, E. and Chen, X. (2023) Prediabetes and the Risk of Lung Cancer Incidence and Mortality: A Meta-Analysis. Journal of Diabetes Investigation, 14, 1209-1220. https://doi.org/10.1111/jdi.14057 |
| [15] | Keesari, P.R., Jain, A., Ganampet, N.R., et al. (2024) Association between Prediabetes and Breast Cancer: A Comprehensive Meta-Analysis. Breast Cancer Research and Treatment, 204, 1-13. https://doi.org/10.1007/s10549-023-07181-x |
| [16] | Scappaticcio, L., Maiorino, M.I., Bellastella, G.., et al. (2017) Insights into the Relationships between Diabetes, Prediabetes, and Cancer. Endocrine, 56, 231-239. https://doi.org/10.1007/s12020-016-1216-y |
| [17] | 高慧, 朱旭婷, 张磊, 等. 糖尿病前期与肿瘤发病风险研究[J]. 预防医学, 2023, 35(11): 931-934. |
| [18] | Jaacks, L.M., Vandevijvere, S., Pan, A., et al. (2019) The Obesity Transition: Stages of the Global Epidemic. The Lancet Diabetes and Endocrinology, 7, 231-240. https://doi.org/10.1016/S2213-8587(19)30026-9 |
| [19] | Lee, E.Y. and Yoon, K.H. (2018) Epidemic Obesity in Children and Adolescents: Risk Factors and Prevention. Frontiers of Medicine, 12, 658-666. https://doi.org/10.1007/s11684-018-0640-1 |
| [20] | Zhu, J., Zhang, Y., Wu, Y., et al. (2022) Obesity and Dyslipidemia in Chinese Adults: A Cross-Sectional Study in Shanghai, China. Nutrients, 14, Article 2321. https://doi.org/10.3390/nu14112321 |
| [21] | Lin, X. and Li, H. (2021) Obesity: Epidemiology, Pathophysiology, and Therapeutics. Frontiers in Endocrinology, 12, Article 706978. https://doi.org/10.3389/fendo.2021.706978 |
| [22] | Asgari, S., Molavizadeh, D., Soltani, K., et al. (2024) The Impact of Obesity on Different Glucose Tolerance Status with Incident Cardiovascular Disease and Mortality Events over 15 Years of Follow-Up: A Pooled Cohort Analysis. Diabetology & Metabolic Syndrome, 16, Article No. 27. https://doi.org/10.1186/s13098-023-01253-0 |
| [23] | 贺媛, 曾强, 赵小兰. 中国成人肥胖、中心性肥胖与高血压和糖尿病的相关性研究[J]. 解放军医学杂志, 2015, 40(10): 803-808. |
| [24] | 张思婷, 张继国, 贾小芳, 等. 2018年中国15省份18~65岁居民肥胖与2型糖尿病患病的关联研究[J]. 中华流行病学杂志, 2022, 43(10): 1596-1602. |
| [25] | 李芝, 陈怡, 郭高明, 等. 腰围、体脂率、脂质蓄积指数与糖尿病前期的关系探讨[J]. 广东医科大学学报, 2020, 38(1): 64-66. |
| [26] | Wang, S., Li, W., Qiao, Y., et al. (2021) Abnormal Glucose in Pre-School Children and the Association with Obesity/Physical Activity: A Large Population-Based Study. Diabetes/Metabolism Research and Reviews, 37, e3442. https://doi.org/10.1002/dmrr.3442 |
| [27] | Liu, C., Foti, K., Grams, M.E., et al. (2020) Trends in Self-Reported Prediabetes and Metformin Use in the USA: NHANES 2005-2014. Journal of General Internal Medicine, 35, 95-101. https://doi.org/10.1007/s11606-019-05398-5 |
| [28] | Lushchak, V.I., Covasa, M., Abrat, O.B., et al. (2023) Risks of Obesity and Diabetes Development in the Population of the Ivano-Frankivsk Region in Ukraine. EXCLI Journal, 22, 1047-1054. |
| [29] | Jabbar, P.K., Nair, A., Chellamma, J., et al. (2023) Type 2 Diabetes and Precursors in Community Dwelling Asian Indian Adult Youth. Indian Journal of Endocrinology and Metabolism, 27, 307-314. https://doi.org/10.4103/ijem.ijem_331_22 |
| [30] | 刘章平. 体重指数、胰岛素抵抗与肥胖糖尿病前期患者的关系[J]. 陕西医学杂志, 2015, 44(9): 1202-1204. |
| [31] | Ma, J., Yank, V., Xiao, L., et al. (2013) Translating the Diabetes Prevention Program Lifestyle Intervention for Weight Loss into Primary Care: A Randomized Trial. JAMA Internal Medicine, 173, 113-121. https://doi.org/10.1001/2013.jamainternmed.987 |
| [32] | Wilmington, R., Ardavani, A., Simenacz, A., et al. (2024) Liraglutide 3.0 Mg (Saxenda？) for Weight Loss and Remission of Pre-Diabetes. Real-World Clinical Evaluation of Effectiveness among Patients Awaiting Bariatric Surgery. Obesity Surgery, 34, 286-289. https://doi.org/10.1007/s11695-023-06895-7 |
| [33] | Cetin, E., Pedersen, B., Porter, L.M., et al. (2023) Protocol for a Randomized Placebo-Controlled Clinical Trial Using Pure Palmitoleic Acid to Ameliorate Insulin Resistance and Lipogenesis in Overweight and Obese Subjects with Prediabetes. Frontiers in Endocrinology, 14, Article 1306528. https://doi.org/10.3389/fendo.2023.1306528 |
| [34] | Czech, M.P. (2020) Mechanisms of Insulin Resistance Related to White, Beige, and Brown Adipocytes. Molecular Metabolism, 34, 27-42. https://doi.org/10.1016/j.molmet.2019.12.014 |
| [35] | Yang, Q., Vijayakumar, A. and Kahn, B.B. (2018) Metabolites as Regulators of Insulin Sensitivity and Metabolism. Nature Reviews Molecular Cell Biology, 19, 654-672. https://doi.org/10.1038/s41580-018-0044-8 |
| [36] | Saltiel, A.R. and Olefsky, J.M. (2017) Inflammatory Mechanisms Linking Obesity and Metabolic Disease. Journal of Clinical Investigation, 127, 1-4. https://doi.org/10.1172/JCI92035 |
| [37] | Zhang, Y., Sowers, J.R. and Ren, J. (2018) Targeting Autophagy in Obesity: From Pathophysiology to Management. Nature Reviews Endocrinology, 14, 356-376. https://doi.org/10.1038/s41574-018-0009-1 |
| [38] | Soussi, H., Clément, K. and Dugail, I. (2016) Adipose Tissue Autophagy Status in Obesity: Expression and Flux— Two Faces of the Picture. Autophagy, 12, 588-589. https://doi.org/10.1080/15548627.2015.1106667 |
| [39] | Grasset, E. and Burcelin, R. (2019) The Gut Microbiota to the Brain Axis in the Metabolic Control. Reviews in Endocrine and Metabolic Disorders, 20, 427-438. https://doi.org/10.1007/s11154-019-09511-1 |
