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肝细胞癌分级与动脉血供的相关性研究
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Abstract:
肝细胞癌(HCC)是世界上最常见的恶性肿瘤之一。影像学的最新进展使研究人员能够使用CT等工具评估肝细胞病变，尤其是发育不良结节或早期HCC的血流动力学。在肝癌进展过程中，大多数肝细胞结节在门脉血流丧失之前表现出动脉血流的恶化。随后，由于新生血管化动脉的显著增加，动脉血流成为主导。随着肿瘤的进展，门静脉血流量减少，最终肿瘤主要由动脉血供。再生结节、发育不良结节和分化良好的HCC中结节内血液供应的变化已被充分描述。本研究的目的是阐明肝细胞癌发生发展过程中动脉血供的时序性变化，重点是晚期HCC。
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world. The latest advances in imaging enable researchers to use tools such as CT to evaluate the hemodynamics of hepatocytic lesions, especially dysplastic nodules or early HCC. During the progression of hepatocellular carcinoma, most hepatocyte nodules show deterioration of arterial blood flow before the loss of portal blood flow. Subsequently, due to the significant increase of neovascularization artery, arterial blood flow became dominant. With the development of the tumor, the blood flow of the portal vein decreases, and finally the tumor is mainly supplied by the artery. The changes of blood supply in regenerated nodules, dysplastic nodules and well-differentiated HCC nodules have been fully described. The purpose of this study was to clarify the sequential changes of arterial blood supply during the occurrence and development of hepatocellular carcinoma, with emphasis on advanced HCC.
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