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新型冠状病毒感染与睡眠障碍关系研究进展
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Abstract:
新型冠状病毒肺炎是由严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)感染引起的一种新的高传染性疾病，2019年底出现，引发全球大流行。临床观察发现，部分新冠患者发病后数月仍未完全恢复，出现咳嗽、胸闷、气短、嗅觉、味觉减退、疲劳、失眠、焦虑、抑郁等症状，即长新冠综合征。其中睡眠障碍非常常见，且对于感染后人群的工作、生活及心理造成了很大困扰，但其发病机制尚不清楚，因此很有必要进行探究。本文对新型冠状病毒感染引起睡眠障碍的可能机制进行综述，以利于更深入地了解长新冠的发病机制、预警信号、早期干预措施，从而提出更好的治疗方案。
COVID-19 is a new highly infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which emerged in late 2019, triggering a global pandemic. Clinical observations have found that some COVID-19 patients still have not fully recovered after several months of onset, and they have symptoms such as cough, chest tightness, shortness of breath, decreased sense of smell and taste, fatigue, insomnia, anxiety, and depression, namely long COVID-19 syndrome. Among them, sleep disorder is very common, and it causes great distress to the work, life, and psychology of the infected population. However, its pathogenesis is still unclear, so it is necessary to explore. This article reviews the possible mechanisms of sleep disorder caused by novel coronavirus infection, in order to better understand the pathogenesis, warning signals, and early intervention measures of COVID-19, so as to put forward better treatment plans.
| [1] | Brodin, P. (2021) Immune Determinants of COVID-19 Disease Presentation and Severity. Nature Medicine, 27, 28-33. https://doi.org/10.1038/s41591-020-01202-8 |
| [2] | Huang, C., Huang, L., Wang, Y., et al. (2021) 6-Month Consequences of COVID-19 in Patients Discharged from Hospital: A Cohort Study. The Lancet, 397, 220-232. https://doi.org/10.1016/S0140-6736(20)32656-8 |
| [3] | Ballering, A.V., Van Zon, S.K.R., Olde Hartman, T.C., et al. (2022) Persistence of Somatic Symptoms after COVID-19 in the Netherlands: An Observational Cohort Study. The Lancet, 400, 452-461. https://doi.org/10.1016/S0140-6736(22)01214-4 |
| [4] | Taquet, M., Geddes, J.R., Husain, M., et al. (2021) 6-Month Neurological and Psychiatric Outcomes in 236739 Survivors of COVID-19: A Retrospective Cohort Study Using Electronic Health Records. The Lancet Psychiatry, 8, 416-427. https://doi.org/10.1016/S2215-0366(21)00084-5 |
| [5] | Janiri, D., Carfi, A., Kotzalidis, G.D., et al. (2021) Posttraumatic Stress Disorder in Patients after Severe COVID-19 Infection. JAMA Psychiatry, 78, 567-569. https://doi.org/10.1001/jamapsychiatry.2021.0109 |
| [6] | Nicholson, K., Rodrigues, R., Anderson, K.K., et al. (2020) Sleep Behaviours and Multimorbidity Occurrence in Middle-Aged and Older Adults: Findings from the Canadian Longitudinal Study on Aging (CLSA). Sleep Medicine, 75, 156-162. https://doi.org/10.1016/j.sleep.2020.07.002 |
| [7] | Sabia, S., Dugravot, A., Léger, D., et al. (2022) Association of Sleep Duration at Age 50, 60, and 70 Years with Risk of Multimorbidity in the UK: 25-Year Follow-Up of the Whitehall II Cohort Study. PLOS MEDICINE, 19, e1004109. https://doi.org/10.1371/journal.pmed.1004109 |
| [8] | Fan, M., Sun, D., Zhou, T., et al. (2020) Sleep Patterns, Genetic Susceptibility, and Incident Cardiovascular Disease: A Prospective Study of 385 292 UK Biobank Participants. European Heart Journal, 41, 1182-1189. https://doi.org/10.1093/eurheartj/ehz849 |
| [9] | 李雪丽, 张斌. 睡眠障碍与焦虑抑郁障碍的联系[J]. 中国临床医生杂志, 2018, 46(2): 131-133. |
| [10] | Kalamara, E., et al. (2022) Persistent Sleep Quality Deterioration among Post-COVID-19 Patients: Results from a 6-Month Follow-Up Study. Journal of Personalized Medicine, 12, Article 1909. https://doi.org/10.3390/jpm12111909 |
| [11] | Xie, Y., Xu, E. and Al-Aly, Z. (2022) Risks of Mental Health Outcomes in People with COVID-19: A Cohort Study. BMJ, 376, e068993. https://doi.org/10.1136/bmj-2021-068993 |
| [12] | Zawilska, J.B. and Kuczyńska, K. (2022) Psychiatric and Neurological Complications of Long COVID. Journal of Psychiatric Research, 156, 349-360. https://doi.org/10.1016/j.jpsychires.2022.10.045 |
| [13] | Riemann, D., Spiegelhalder, K., Feige, B., et al. (2010) The Hyperarousal Model of Insomnia: A Review of the Concept and Its Evidence. Sleep Medicine Reviews, 14, 19-31. https://doi.org/10.1016/j.smrv.2009.04.002 |
| [14] | Ribeiro, A., Gabriel, R., Garcia, B., et al. (2022) Temporal Relations between Peripheral and Central Arousals in Good and Poor Sleepers. Proceedings of the National Academy of Sciences, 119, e2201143119. https://doi.org/10.1073/pnas.2201143119 |
| [15] | Kang, L.J., Li, Y., Hu, S.H., et al. (2020) The Mental Health of Medical Workers in Wuhan, China Dealing with the 2019 Novel Coronavirus. The Lancet Psychiatry, 7, E14. https://doi.org/10.1016/S2215-0366(20)30047-X |
| [16] | 刘慧, 孙龙, 刘婷婷, 等. 综合医院医务人员的自杀意念及其相关因素[J]. 中国心理卫生杂志, 2021, 35(5): 389-394. |
| [17] | Luciano, F., Cenacchi, V., Vegro, V. and Pavei, G. (2021) COVID-19 Lockdown: Physical Activity, Sedentary Behaviour and Sleep in Italian Medicine Students. European Journal of Sport Science, 21, 1459-1468. https://doi.org/10.1080/17461391.2020.1842910 |
| [18] | Zhao, J., Liu, C., Zhang, F., et al. (2022) A Paraventricular Thalamus to Central Amygdala Neural Circuit Modulates Acute Stress-Induced Heightened Wakefulness. Cell Reports, 41, Article 111824. https://doi.org/10.1016/j.celrep.2022.111824 |
| [19] | Wright, C.D., Tiani, A.G., Billingsley, A.L., et al. (2019) A Framework for Understanding the Role of Psychological Processes in Disease Development, Maintenance, and Treatment: The 3P-Disease Model. Frontiers in Psychology, 10, Article 2498. https://doi.org/10.3389/fpsyg.2019.02498 |
| [20] | Chiu, H.F., Leung, T., Lam, L.C., et al. (1999) Sleep Problems in Chinese Elderly in Hong Kong. Sleep, 22, 717-726. https://doi.org/10.1093/sleep/22.6.717 |
| [21] | Zhang, B. and Wing, Y.-K. (2006) Sex Differences in Insomnia: A Meta-Analysis. Sleep, 29, 85-93. https://doi.org/10.1093/sleep/29.1.85 |
| [22] | Schutte-Rodin, S., Broch, L., Buysse, D., et al. (2008) Clinical Guideline for the Evaluation and Management of Chronic Insomnia in Adults. Journal of Clinical Sleep Medicine, 4, 487-504. https://doi.org/10.5664/jcsm.27286 |
| [23] | Morin, C.M., Leblanc, M., Ivers, H., et al. (2014) Monthly Fluctuations of Insomnia Symptoms in a Population-Based Sample. Sleep, 37, 319-326. https://doi.org/10.5665/sleep.3406 |
| [24] | Poluektov, M.G. and Pchelina, P.V. (2015) Chronic Insomnia: Treatment Methods Based on the Current “3p” Model of Insomnia. Journal of Neurology and Psychiatry, 12, 141-147. https://doi.org/10.17116/jnevro2015115112141-147 |
| [25] | Hashimoto, Y. and Campbell, M. (2020) Tight Junction Modulation at the Blood-Brain Barrier: Current and Future Perspectives. Biochimica et Biophysica Acta (BBA)-Biomembranes, 1862, Article 183298. https://doi.org/10.1016/j.bbamem.2020.183298 |
| [26] | Rhea, E.M., Logsdon, A.F., Hansen, K.M., et al. (2021) The S1 Protein of SARS-CoV-2 Crosses the Blood-Brain Barrier in Mice. Nature Neuroscience, 24, 368-378. https://doi.org/10.1038/s41593-020-00771-8 |
| [27] | Huang, C., Wang, Y., Li, X., et al. (2020) Clinical Features of Patients Infected with 2019 Novel Coronavirus in Wuhan, China. The Lancet, 395, 497-506. https://doi.org/10.1016/S0140-6736(20)30183-5 |
| [28] | Wrapp, D., Wang, N., Corbett, K.S., et al. (2020) Cryo-EM Structure of the 2019-nCoV Spike in the Prefusion Conformation. Science, 367, 1260-1263. https://doi.org/10.1126/science.abb2507 |
| [29] | Alenina, N. and Bader, M. (2019) ACE2 in Brain Physiology and Pathophysiology: Evidence from Transgenic Animal Models. Neurochemical Research, 44, 1323-1329. https://doi.org/10.1007/s11064-018-2679-4 |
| [30] | Siahaan, Y.M.T., Puspitasari, V. and Pangestu, A.R. (2020) COVID-19-Associated Encephalitis: Systematic Review of Case Reports Findings on Cytokine-Immune-Mediated Inflammation as an Underlying Mechanism. Research Square. https://doi.org/10.21203/rs.3.rs-65579/v1 |
| [31] | Baig, A.M., Khaleeq, A., Ali, U. and Syeda, H. (2020) Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms. ACS Chemical Neuroscience, 11, 995-998. https://doi.org/10.1021/acschemneuro.0c00122 |
| [32] | Maury, A., Lyoubi, A., Peiffer-Smadja, N., et al. (2021) Neurological Manifestations Associated with SARS-CoV-2 and Other Coronaviruses: A Narrative Review for Clinicians. Revue Neurologique, 177, 51-64. https://doi.org/10.1016/j.neurol.2020.10.001 |
| [33] | Jiang, F., Deng, L., Zhang, L., et al. (2020) Review of the Clinical Characteristics of Coronavirus Disease 2019 (COVID-19). Journal of General Internal Medicine, 35, 1545-1549. https://doi.org/10.1007/s11606-020-05762-w |
| [34] | Douaud, G., Lee, S., Alfaro-Almagro, F., et al. (2022) SARS-CoV-2 Is Associated with Changes in Brain Structure in UK Biobank. Nature, 604, 697-707. https://doi.org/10.1038/s41586-022-04569-5 |
| [35] | Sydney, R.S., Sabrina, C.R., Alison, G., et al. (2022) SARS-CoV-2 Infection and Persistence in the Human Body and Brain at Autopsy. Nature, 612, 758-763. https://doi.org/10.1038/s41586-022-05542-y |
| [36] | Ramakrishnan, R.K., Kashour, T., Hamid, Q., et al. (2021) Unraveling the Mystery Surrounding Post-Acute Sequelae of COVID-19. Frontiers in Immunology, 12, Article 686029. https://doi.org/10.3389/fimmu.2021.686029 |
| [37] | Zhang, L., Richards, A., Barrasa, M.I., et al. (2021) Reverse-Transcribed SARS-CoV-2 RNA Can Integrate into the Genome of Cultured Human Cells and Can Be Expressed in Patient-Derived Tissues. Proceedings of the National Academy of Sciences, 118, e2105968118. https://doi.org/10.1073/pnas.2105968118 |
| [38] | Mehta, P., Mcauley, D.F., Brown, M., et al. (2020) COVID-19: Consider Cytokine Storm Syndromes and Immunosuppression. The Lancet, 395, 1033-1034. https://doi.org/10.1016/S0140-6736(20)30628-0 |
| [39] | Wan, S., Yi, Q., Fan, S., et al. (2020) Relationships among Lymphocyte Subsets, Cytokines, and the Pulmonary Inflammation Index in Coronavirus (COVID-19) Infected Patients. British Journal of Haematology, 189, 428-437. https://doi.org/10.1111/bjh.16659 |
| [40] | Klironomos, S., Tzortzakakis, A., Kits, A., et al. (2020) Nervous System Involvement in Coronavirus Disease 2019: Results from a Retrospective Consecutive Neuroimaging Cohort. Radiology, 297, E324-E334. https://doi.org/10.1148/radiol.2020202791 |
