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2型糖尿病合并肌少症血清标志物研究进展
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Abstract:
2型糖尿病是一种与胰岛素分泌障碍相关的代谢性疾病，肌少症是指机体骨骼肌质量和数量减少、肌肉力量和功能减退导致疾病的一种慢性进行性发展过程。在T2DM病程中，肌少症的发病风险明显高于正常人群，因此近些年来，肌少症也被认为是T2DM的一种并发症。但目前T2DM患者肌少症发病概率高的原因尚不明确，同时目前肌少症的诊断方法为肌量、肌力、步速、身体活动能力等方面的综合评估，其中肌量检测依赖于双能X线摄像吸收法，而其余三项检查易受到身体状况的影响。本文旨在探讨选取血清标志物，为早期诊断和干预肌少症提供帮助，用以改善患者预后。
Type 2 diabetes mellitus is a metabolic disease related to insulin secretion disorder, and sarcopenia refers to a chronic progressive development process caused by the decrease of skeletal muscle quality and quantity and muscle strength and function. In the course of T2DM, the risk of sarcopenia is obviously higher than that of normal people, so in recent years, sarcopenia is also considered as a complication of T2DM. However, the reason for the high incidence rate of sarcopenia in T2DM patients is still unclear. At the same time, the current diagnostic method of sarcopenia is comprehensive evaluation of muscle mass, muscle strength, walking speed and physical activity ability, among which muscle mass detection depends on dual-energy X-ray absorption method, while the other three tests are easily affected by physical condition. The purpose of this paper is to explore the selection of serum markers, to provide help for early diagnosis and intervention of sarcopenia and to improve the prognosis of patients.
| [1] | Li, Y., Teng, D., Shi, X., et al. (2020) Prevalence of Diabetes Recorded in Mainland China Using 2018 Diagnostic Criteria from the American Diabetes Association: National Cross Sectional Study. BMJ, 369, M997. https://doi.org/10.1136/bmj.m997 |
| [2] | Morley, J.E. (2008) Sarcopenia: Diagnosis and Treatment. Journal of Nutrition Health & Aging, 12, 452-456. https://doi.org/10.1007/BF02982705 |
| [3] | Liccini, A. and Malmstrom, T.K. (2016) Frailty and Sarcopenia as Predictors of Adverse Health Outcomes in Persons with Diabetes Mellitus. Journal of the American Medical Directors Association, 17, 846-851. |
| [4] | Onyemaechi, S. and Ezenwaka, U. (2022) Influence of Sub-National Social Health Insurance Scheme on Enrollees’ Health Seeking Behaviour in Anambra State, Nigeria: A Pre and Post Study. BMC Public Health, 22, Article No. 1171. https://doi.org/10.1186/s12889-022-13606-x |
| [5] | Bouchard, D.R., Dionne, I.J. and Brochu, M. (2009) Sarcopenic/Obesity and Physical Capacity in Older Men and Women: Data from the Nutrition as a Determinant of Successful Aging (NuAge)—The Quebec Longitudinal Study. Obesity, 17, 2082-2088. https://doi.org/10.1038/oby.2009.109 |
| [6] | 汪瑞琴, 吕杰, 韩佩佩, 等. 肌少症诊断技术研究进展[J]. 中华实用诊断与治疗杂志, 2023, 37(8): 854-856. |
| [7] | 张静, 陈佩杰, 肖卫华. 雄激素对骨骼肌蛋白质代谢的调控及其机制[J]. 生命科学, 2019, 31(8): 826-832. https://doi.org/10.13376/j.cbls/2019101 |
| [8] | Bodine, S.C. and Baehr, L.M. (2015) Skeletal Muscle Atrophy and the E3 Ubiquitin Ligases MuRF1 and MAFbx/Atrogin-1. American Journal of Physiology-Endocrinology and Metabolism, 307, E469. https://doi.org/10.1152/ajpendo.00204.2014 |
| [9] | Sakuma, K. and Yamaguchi, A. (2012) Sarcopenia and Cachexia: The Adaptations of Negative Regulators of Skeletal Muscle Mass. Journal of Cachexia Sarcopenia & Muscle, 3, 77-94. https://doi.org/10.1007/s13539-011-0052-4 |
| [10] | Chen, W., Yao, C. and Lu, X. (2014) Optimal Design Activated Sludge Process by Means of Multi-Objective Optimization: Case Study in Benchmark Simulation Model 1 (BSM1). Water Science & Technology, 69, 2052-2058. https://doi.org/10.2166/wst.2014.119 |
| [11] | 侯佳彤, 于萍, 潘慧, 陈适. 正常老年人使用重组人生长激素替代治疗对其生活质量的影响及可行性[J]. 中华临床医师杂志: 电子版, 2014, 4(21): 3863-3866. |
| [12] | Li, C.W., Yu, K., Shyh‐Chang, N., et al. (2019) Circulating Factors Associated with Sarcopenia during Ageing and after Intensive Lifestyle Intervention. Journal of Cachexia, Sarcopenia and Muscle, 10, 586-600. https://doi.org/10.1002/jcsm.12417 |
| [13] | Tay, L., Ding, Y.Y., et al. (2015) Sex-Specific Differences in Risk Factors for Sarcopenia amongst Community-Dwelling Older Adults. Age (Dordrecht, Netherlands), 37, Article No. 121. https://doi.org/10.1007/s11357-015-9860-3 |
| [14] | Bartke, A. and Darcy, J. (2017) GH and Ageing: Pitfalls and New Insights. Best Practice & Research Clinical Endocrinology & Metabolism, 31, 113-125. https://doi.org/10.1016/j.beem.2017.02.005 |
| [15] | Calvani, R., Joseph, A.M., Adhihetty, P.J., et al. (2012) Mitochondrial Pathways in Sarcopenia of Aging and Disuse Muscle Atrophy. Biological Chemistry, 394, 393-414. https://doi.org/10.1515/hsz-2012-0247 |
| [16] | Xin, C., Sun, X., Lu, L. and Shan, L. (2021) Prevalence of Sarcopenia in Older Chinese Adults: A Systematic Review and Meta-Analysis. BMJ Open, 11, e041879. https://doi.org/10.1136/bmjopen-2020-041879 |
| [17] | Cruz-Jentoft, A.J., Bahat, G., Bauer, J., et al. (2019) Sarcopenia: Revised European Consensus on Definition and Diagnosis (Vol 48, Pg 16, 2019). Age and Ageing: The Journal of the British Geriatrics Society and the British Society for Research on Ageing, No. 4, 48. |
| [18] | Thoma, A. and Lightfoot, A.P. (2018) NF-κB and Inflammatory Cytokine Signalling: Role in Skeletal Muscle Atrophy. In: Xiao, J.J., Ed., Muscle Atrophy, Springer, Berlin, 267-279. https://doi.org/10.1007/978-981-13-1435-3_12 |
| [19] | Rong, Y.-D., et al. (2018) Study on Relationship between Elderly Sarcopenia and Inflammatory Cytokine IL-6, Anti-Inflammatory Cytokine IL-10. BMC Geriatrics, 18, Article No. 308. https://doi.org/10.1186/s12877-018-1007-9 |
| [20] | Tazawa, R., Uchida, K., Fujimaki, H., et al. (2019) Elevated Leptin Levels Induce Inflammation through IL-6 in Skeletal Muscle of Aged Female Rats. BMC Musculoskeletal Disorders, 20, Article No. 199. https://doi.org/10.1186/s12891-019-2581-5 |
| [21] | 丁婷婷, 王会玲, 陆石, 等. 炎症因子TNF-α/IL-6对透析患者骨骼肌消耗及Myostatin和Atrogin-1表达的影响[J]. 中国血液净化, 2013, 12(11): 581-585. https://doi.org/10.3969/J.ISSN.1671-4091.2013.11.001 |
| [22] | Shokri-Mashhadi, N., Moradi, S., Heidari, Z. and Saadat, S. (2021) Association of Circulating C-Reactive Protein and High-Sensitivity C-Reactive Protein with Components of Sarcopenia: A Systematic Review and Meta-Analysis of Observational Studies. Experimental Gerontology, 150, Article ID: 111330. https://doi.org/10.1016/j.exger.2021.111330 |
| [23] | 阳建政, 邹丽华, 杨涛, 等. 2型糖尿病患者并发肌肉减少症的影响因素分析[J]. 陆军军医大学学报, 2023, 45(14): 1562-1568. |
| [24] | 丁扬, 凌琰, 成金罗, 等. 住院2型糖尿病患者血尿酸水平与肌量减少的相关性[J]. 中国骨质疏松杂志, 2022, 28(7): 1008-1012. |
| [25] | Casati, M., Costa, A.S., Capitanio, D., et al. (2019) The Biological Foundations of Sarcopenia: Established and Promising Markers. Frontiers in Medicine (Lausanne), 6, Article No. 184. https://doi.org/10.3389/fmed.2019.00184 |
| [26] | 张兴宇, 郭琪, 陈小雨. 晚期糖基化终末产物与肌少症及其参数的研究进展[J]. 中国骨质疏松杂志, 2023, 29(5): 758-764. |
| [27] | Tong, T.Y.N., Bradbury, K.E. and Key, T.J. (2019) RE: “Associations of Dietary Protein Intake with Fat-Free Mass and Grip Strength: A Cross-Sectional Study in 146,816 UK Biobank Participants”. American Journal of Epidemiology, 188, 977-978. https://doi.org/10.1093/aje/kwz029 |
| [28] | Chen, J.H., Lin, X., Bu, C. and Zhang, X. (2018) Role of Advanced Glycation End Products in Mobility and Considerations in Possible Dietary and Nutritional Intervention Strategies. Nutrition & Metabolism, 15, Article No. 72. https://doi.org/10.1186/s12986-018-0306-7 |
| [29] | Liu, X., Xia, X., Hu, F., et al. (2021) Nutrition Status Mediates the Association between Cognitive Decline and Sarcopenia. Aging, 13, 8599-8610. https://doi.org/10.18632/aging.202672 |
| [30] | Umegaki, H. (2015) Sarcopenia and Diabetes: Hyperglycemia Is a Risk Factor for Age‐Associated Muscle Mass and Functional Reduction. Journal of Diabetes Investigation, 6, 623-624. https://doi.org/10.1111/jdi.12365 |
| [31] | 陈俏, 邓斌, 陈婷. 老年住院2型糖尿病患者合并肌少症的情况及其影响因素分析[J]. 糖尿病新世界, 2022, 25(19): 43-46. |
| [32] | Umegaki, H. (2016) Sarcopenia and Frailty in Older Patients with Diabetes Mellitus. Geriatrics & Gerontology International, 16, 293-299. https://doi.org/10.1111/ggi.12688 |
| [33] | Jung, H.W., Park, J.H., Kim, D.A., et al. (2021) Association between Serum FGF21 Level and Sarcopenia in Older Adults. Bone, 145, Article ID: 115877. https://doi.org/10.1016/j.bone.2021.115877 |
