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Pharmacy Information 2024
微针给药技术：一种突破传统药物递送方法的新途径
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Abstract:
微机电系统的快速发展导致人们对微纳米级产品的实用化需求日益强烈，微针透皮给药技术越来越受到人们的关注和关注。微针依靠其微米级的锋利尖端刺入皮肤角质层，形成一定深度的微孔，方便药物分子更轻松地穿过皮肤，或直接实现药物注射，从而实现无痛高效的透皮给药、渗透吸收的目的。不同类型的微针结构具有不同的给药方式和效果。同时，精准给药也对微针阵列微加工技术提出了更高的要求。本文首先系统介绍了用于透皮给药的微针，然后对不同结构的聚合物微针进行力学分析和强度验证，并研究了以微注塑技术为代表的聚合物微针阵列的精密加工。对微针技术的方法以及在新型透皮给药系统中的应用进行了综述。
The rapid development of micro electromechanical systems has led to an increasingly strong demand for the practical application of micro-and nanoscale products, and micro needle transdermal drug delivery technology has attracted more and more attention and concern. Micro needles rely on their micron-level sharp tips to penetrate into the stratum corneum of the skin to form micro-pores of a certain depth, allowing drug molecules to more easily pass through the skin, or to directly inject drugs, thereby achieving painless and efficient transdermal drug delivery, also the purpose of penetration and absorption. Different types of micro needle structures have different delivery methods and effects. At the same time, precise drug delivery also puts forward higher requirements for micro needle array micro-processing technology. This article first systematically introduces micro needles used for transdermal drug delivery, then conducts mechanical analysis and strength verification of polymer micro needles with different structure, and studies the precision processing of polymer micro needle arrays represented by microinjection molding technology. Methods of micro needle technology and their application in novel transdermal drug delivery systems are reviewed.
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