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ceRNA在膀胱癌中的研究进展
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Abstract:
膀胱癌是全世界范围内的一种常见恶性肿瘤，是泌尿系统中发生率最高的恶性癌症，严重影响人们健康。竞争性内源RNA (competing endogenous RNA, ceRNA)是一种新的转录后RNA相互调控机制，越来越多的研究发现长链非编码RNA (long non-coding RNA, lncRNA)、环状RNA (circular RNA, circRNA)和假基因(pseudogenes)可以与微小RNA (micro RNA, miRNA)竞争，影响靶RNA的稳定性或翻译，从而调控基因表达。由于任何拥有miRNA反应元件结构的转录产物理论上都能够作为ceRNA发挥功能，ceRNA理论对整合疾病发病机理，尤其对于肿瘤研究有重要意义。目前越来越多的研究表明ceRNA在肿瘤的基因调控及肿瘤细胞增殖、凋亡、细胞周期、侵袭和转移等各种生物过程中发挥重要作用。本文对ceRNA分类及常见的ceRNA在膀胱癌中的研究进展作一综述。
Bladder cancer is a common malignant tumor worldwide and the most common malignant cancer in the urinary system, which seriously affects people’s health. Competing endogenous RNA is a new RNA transcription regulatory mechanism. More and more studies have found that lncRNA, circRNA and pseudogenes that can compete with miRNA, influence the stability of the target RNA or transla-tion, thus regulate gene expression. Given that any transcripts harbouring MREs can theoretically function as ceRNAs, ceRNAs theory plays an important role in coordinating disease pathogenesis, especially in tumor research. At present, more and more studies have shown that ceRNA plays a pivotal role in the gene regulation and the proliferation, apoptosis, cell cycle, invasion and metasta-sis of cancer cells. This article reviews the progress of ceRNA classification, functions in bladder cancer.
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