Introduction: In December 2019, COVID 19 spread worldwide, but did not officially start in MOROCCO until March 02, 2020. Since then, this pandemic has significantly impacted the health status of patients in general and cancer patients in particular. The main objective of our study is to evaluate the prognosis of patients treated for cancer and infected with COVID-19. Material and method: A descriptive study with prospective collection was carried out at the medical oncology department of CHU Hassan II in FEZ over a period of two years, from March 2020 to March 2022. Data was carried out on the software SPSS. Results: One hundred cancer patients tested positive for COVID-19 infection and were collected within our department. The average age was 56 years [22-91]. The sex ratio was 1.2. Patients with breast cancer were the most affected by this infection (34%). The clinical symptomatology was dominated by the respiratory syndrome (45%).The diagnosis was made through thoracic CT scan in 62% of cases. 76% of patients were in a metastatic stage. 96% of patients were undergoing oncological treatment. For symptomatique patients, the standard treatment approach involved using antibiotics in 76% of cases. Evolution was marked by recovery in 79% of patients, with a death rate of 12% in this cancer patient population. Conclusion: COVID-19 infection is particularly severe in cancer patients. Mortality among these patients remains high and is associated with overall patient characteristics. However, anticancer treatments have not shown deleterious effects on the course of COVID-19.
References
[1]
Wu, F., Zhao, S., Yu, B., Chen, Y.M., Wang, W., Song, Z.G., Hu, Y., Tao, Z.W., et al. (2020) A New Coronavirus Associated with Human Respiratory Disease in China. Nature, 579, 265-269. https://doi.org/10.1038/s41586-020-2008-3
[2]
Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., et al. (2020) Genomic Characterisation and Epidemiology of 2019 Novel Coronavirus: Implications for Virus Origins and Receptor Binding. Lancet, 395, 565-574.
https://doi.org/10.1016/S0140-6736(20)30251-8
[3]
WHO (2020) Coronavirus Disease (COVID-19) Pandemic.
https://www.who.int/europe/emergencies/situations/covid-19
[4]
Ministry of Health of Morocco (2020) Coronavirus Disease COVID-19: Situation Report. https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200816-covid-19-sitrep-209.pdf
[5]
Liang, W., Guan, W., Chen, R., et al. (2020) Cancer Patients in SARS-CoV-2 Infection: A Nationwide Analysis in China. Lancet Oncology, 21, 335-337.
https://doi.org/10.1016/S1470-2045(20)30096-6
[6]
World Health Organization (2020) Director-General’s Opening Remarks at the Media Briefing on COVID-19.
https://www.who.int/director-general/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020#:~:text=It%20doesn't%20change%20what,controlled%2C%20at%20the%20same%20time
[7]
Ministry of Health of Morocco (2022) Le Portail Officiel du Coronavirus au Maroc.
https://www.covidmaroc.ma/
[8]
Yu, J., Ouyang, W., Chua, M.L. and Xie, C. (2020) SARS-CoV-2 Transmission in Patients with Cancer at a Tertiary Care Hospital in Wuhan, China. JAMA Oncology, 6, 1108-1110. https://doi.org/10.1101/2020.02.22.20025320
[9]
Dai, M., Liu, D., Liu, M., Zhou, F., Li, G. and Xiong, Y. (2020) Patients with Cancer Appear More Vulnerable to SARS-COV-2: A Multicenter Study during the COVID-19 Outbreak. Cancer Discovery, 10, 783-791.
https://doi.org/10.1158/2159-8290.CD-20-0422
[10]
Zhang, L., Zhu, F., Xie, L., Wang, C., Wang, J. and Peng, P. (2020) Clinical Characteristics of COVID-19-Infected Cancer Patients: A Retrospective Case Study in Three Hospitals within Wuhan, China. Annals of Oncology, 31, 894-901.
https://doi.org/10.1016/j.annonc.2020.03.296
[11]
Cai, Q., Huang, D., Ou, P., Yu, H., Zhu, Z. and He, Q. (2020) COVID-19 in a Designated Infectious Diseases Hospital Outside Hubei Province, China. Allergy, 75, 1742-1752. https://doi.org/10.1111/all.14309
[12]
Miyashita, H., Mikami, T., Chopra, N., Yamada, T., Chernyavsky, S., Rizk, D. and Cruz, C. (2020) Do Patients with Cancer Have a Poorer Prognosis of COVID-19? An Experience in New York City. Annals of Oncology, 31, 1088-1089.
https://doi.org/10.1016/j.annonc.2020.04.006
[13]
Zhu, W.J., Wang, J., He, X.H., Qin, Y., Yang, S, and Shi, Y.K. (2020) The Differential Diagnosis of Pulmonary Infiltrates in Cancer Patients during the Outbreak of the 2019 Novel Coronavirus Disease. Chinese Journal of Oncology, 42, 305-311.
[14]
Fang, Y., Zhang, H., Xie, J., Lin, M., Ying, L., Pang, P. and Ji, W. (2020) Sensitivity of Chest CT for COVID-19: Comparison to RTPCR. Radiology, 296, E115-E117.
https://doi.org/10.1148/radiol.2020200432
[15]
Moujaess, E., Kourie, H.R. and Ghosn, M. (2020) Cancer Patients and Research during COVID-19 Pandemic: A Systematic Review of Current Evidence. Critical Reviews in Oncology/Hematology, 150, Article ID: 102972.
https://doi.org/10.1016/j.critrevonc.2020.102972
[16]
Albano, D., Bertagna, F., Bertoli, M., Bosio, G., Lucchini, S. and Giubbini, R. (2020) Incidental Findings Suggestive of COVID-19 in Asymptomatic Patients Undergoing Nuclear Medicine Procedures in a Hig-Prevalence Region. Journal of Nuclear Medicine, 61, 632-636. https://doi.org/10.2967/jnumed.120.246256
[17]
Russell, C.D., Millar, J.E. and Baillie, J.K. (2020) Clinical Evidence Does Not Support Corticosteroid Treatment for 2019-nCoV Lung Injury. Lancet, 395, 473-475.
https://doi.org/10.1016/S0140-6736(20)30317-2
