|
|
成人阻塞性睡眠呼吸暂停与耳鸣的关联性研究
|
Abstract:
目的：探讨美国20~69岁成人中阻塞性睡眠呼吸暂停(OSA)与耳鸣的关系。方法：采用2015~2016年美国国家健康与营养检查调查(NHANES)的数据，纳入了具有完整研究数据和混杂因素信息的参与者。采用多因素logistic回归分析和亚组分析探讨OSA与耳鸣的关系。结果：研究共纳入3175名参与者。调整所有协变量后，多因素logistic回归显示OSA与耳鸣相关(OR = 1.52, 95% CI 1.16~1.99)。在亚组分析中，男性和女性均发现OSA与耳鸣相关(P < 0.05)。结论：在本研究中，我们发现OSA与耳鸣有关。因此，OSA是耳鸣的危险因素之一。
Objective: To explore the association of OSA with tinnitus in adults aged 20~69 years in the United States. Methods: Using data from the National Health and Nutrition Examination Survey (NHANES) 2015~2016, the study included participants with complete study data and confounding factor in-formation. Multivariate logistic regression analysis and subgroup analysis were used to investigate the association between OSA and tinnitus. Results: A total of 3175 participants were included in the study. After adjusting for all covariates, multivariate logistic regression showed that OSA was asso-ciated with tinnitus (OR = 1.52, 95% CI 1.16~1.99). In subgroup analyses, the association of OSA with tinnitus was found in both the male and female groups (P < 0.05 in both). Conclusions: In this study, we found that OSA is associated with tinnitus. Therefore, OSA is one of the risk factors for tin-nitus.
| [1] | Baguley, D., McFerran, D. and Hall, D. (2013) Tinnitus. The Lancet, 382, 1600-1607.
https://doi.org/10.1016/S0140-6736(13)60142-7 |
| [2] | Tunkel, D.E., Bauer, C.A., Sun, G.H., et al. (2014) Clinical Practice Guideline: Tinnitus. Otolaryngology—Head and Neck Surgery, 151, S1-S40. https://doi.org/10.1177/0194599814545325 |
| [3] | Tang, D., Li, H. and Chen, L. (2019) Advances in Understanding, Diagnosis, and Treatment of Tinnitus. In: Li, H. and Chai, R., Eds., Hearing Loss: Mechanisms, Prevention and Cure, Springer, Singapore, 109-128.
https://doi.org/10.1007/978-981-13-6123-4_7 |
| [4] | Rundo, J.V. (2019) Obstructive Sleep Apnea Basics. Cleveland Clinic Journal of Medicine, 86, 2-9.
https://doi.org/10.3949/ccjm.86.s1.02 |
| [5] | Peppard, P.E., Young, T., Barnet, J.H., et al. (2013) Increased Preva-lence of Sleep-Disordered Breathing in Adults. American Journal of Epidemiology, 177, 1006-1014. https://doi.org/10.1093/aje/kws342 |
| [6] | Gottlieb, D.J. and Punjabi, N.M. (2020) Diagnosis and Management of Obstructive Sleep Apnea: A Review. JAMA, 323, 1389-1400. https://doi.org/10.1001/jama.2020.3514 |
| [7] | Veasey, S.C. and Rosen, I.M. (2019) Obstructive Sleep Apnea in Adults. The New England Journal of Medicine, 380, 1442-1449. https://doi.org/10.1056/NEJMcp1816152 |
| [8] | Muxfeldt, E.S., Margallo, V.S., Guimar？es, G.M., et al. (2014) Prevalence and Associated Factors of Obstructive Sleep Apnea in Patients with Resistant Hypertension. American Jour-nal of Hypertension, 27, 1069-1078.
https://doi.org/10.1093/ajh/hpu023 |
| [9] | Abumuamar, A.M., Dorian, P., Newman, D., et al. (2018) The Prevalence of Obstructive Sleep Apnea in Patients with Atrial Fibrillation. Clinical Cardiology, 41, 601-607. https://doi.org/10.1002/clc.22933 |
| [10] | Seiler, A., Camilo, M., Korostovtseva, L., et al. (2019) Prevalence of Sleep-Disordered Breathing after Stroke and TIA: A Meta-Analysis. Neurology, 92, e648-e654. https://doi.org/10.1212/WNL.0000000000006904 |
| [11] | Foster, G.D., Sanders, M.H., Millman, R., et al. (2009) Obstructive Sleep Apnea among Obese Patients with Type 2 Diabetes. Diabetes Care, 32, 1017-1019. https://doi.org/10.2337/dc08-1776 |
| [12] | Chen, P.Y., Chen, T.Y., Chao, P.Z., et al. (2021) REM-Related Obstructive Sleep Apnea and Vertigo: A Retrospective Case-Control Study. PLOS ONE, 16, e0252844. https://doi.org/10.1371/journal.pone.0252844 |
| [13] | Kayabasi, S., Hizli, O. and Yildirim, G. (2019) The Association between Obstructive Sleep Apnea and Hearing Loss: A Cross-Sectional Analysis. European Archives of Oto-Rhino-Laryngology, 276, 2215-2221.
https://doi.org/10.1007/s00405-019-05468-8 |
| [14] | Koo, M. and Hwang, J.H. (2017) Risk of Tinnitus in Patients with Sleep Apnea: A Nationwide, Population-Based, Case-Control Study. Laryngoscope, 127, 2171-2175. https://doi.org/10.1002/lary.26323 |
| [15] | Humes, L.E. and Moore, B.C.J. (2022) Estimation of All-Cause Noise Ex-posure for U.S. Adults from National Survey Data. The Journal of the Acoustical Society of America, 152, 3535-3547. https://doi.org/10.1121/10.0016552 |
| [16] | Lu, C.T., Lee, L.A., Lee, G.S. and Li, H.Y. (2022) Obstructive Sleep Ap-nea and Auditory Dysfunction-Does Snoring Sound Play A Role? Diagnostics, 12, Article 2374. https://doi.org/10.3390/diagnostics12102374 |
| [17] | Martines, F., Ballacchino, A., Sireci, F., et al. (2016) Audiologic Profile of OSAS and Simple Snoring Patients: The Effect of Chronic Nocturnal Intermittent Hypoxia on Auditory Func-tion. European Archives of Oto-Rhino-Laryngology, 273, 1419-1424. https://doi.org/10.1007/s00405-015-3714-6 |
| [18] | Haider, H.F., Boji？, T., Ribeiro, S.F., et al. (2018) Pathophysiol-ogy of Subjective Tinnitus: Triggers and Maintenance. Frontiers in Neuroscience, 12, Article 866. https://doi.org/10.3389/fnins.2018.00866 |
| [19] | 安俊南, 郑芸. 耳鸣发病机制研究进展[J]. 现代临床医学, 2021, 47(1): 57-60. |
| [20] | McFerran, D.J., Stockdale, D., Holme, R., et al. (2019) Why Is There No Cure for Tinnitus? Fron-tiers in Neuroscience, 13, Article 802. https://doi.org/10.3389/fnins.2019.00802 |
| [21] | Milinski, L., Nodal, F.R., Vyazovskiy, V.V., et al. (2022) Tinnitus: At a Crossroad between Phantom Perception and Sleep. Brain Communica-tions, 4, fcac089. https://doi.org/10.1093/braincomms/fcac089 |
| [22] | McNicholas, W.T. and Pevernagie, D. (2022) Obstructive Sleep Apnea: Transition from Pathophysiology to an Integrative Disease Model. Journal of Sleep Research, 31, e13616. https://doi.org/10.1111/jsr.13616 |
