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Pharmacy Information 2024
中药对核受体介导的CYP450酶转录调节机制的研究进展
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Abstract:
近年来中药在临床上的应用日益广泛，但其成分复杂，易导致药物相互作用和不良反应的发生。细胞色素P450酶(Cytochrome P450, CYP450)家族作为最重要的I期代谢酶，负责众多内源性及外源性物质的氧化代谢。核受体(Nuclear Receptors, NRs)是CYP450酶的关键转录调节因子。本文将阐述常见中药及其相关成分通过NRs介导CYP450酶转录调节机制的研究进展。
Traditional Chinese Medicine (TCM) can be a viable supplement for clinical applications. Unlike conventional drug substances, TCM is composed of a complex of biologically active compounds, which can easily lead to drug-drug interaction and adverse reactions. Cytochrome P450 (CYP450), the most important phase I metabolic enzymes, exert pivotal roles in the oxidative metabolism of endogenous and exogenous substances. The metabolic activity of CYP450 is regulated by varieties of nuclear receptors (NRs). In this review, we provide an overview of previous research on the NRs-mediated transcriptional regulation mechanism of CYP450 by TCM and its components.
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