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Health  2024 

Antibiotic Resistance Profile of Salmonella Strains Isolated at the National Clinical Biology and Public Health Laboratory in Bangui, Central African Republic

DOI: 10.4236/health.2024.162014, PP. 160-171

Keywords: Salmonella, Resistance, Antibiotics, Central African Republic

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Abstract:

In Africa, each year, there are estimated to be more than 91 million cases of salmonellosis and 137,000 cases of death. The problem of antibiotic resistance in Salmonella strains is a threat to public health. The objective of this study is to evaluate the antibiotic resistance profile of Salmonella strains isolated in biological products analyzed at the National Laboratory of Clinical Biology and Public Health (NLCBPH) in Bangui. This is, therefore, a cross-sectional study with a descriptive aim, running from January to December 2022. It focused on the strains of Salmonella isolated and identified in stools, urines, and blood samples. For each strain of Salmonella isolated, an antibiogram was carried out following the recommendations of the French Society of Microbiology (CASFM, 2022). A total of 93 strains of Salmonella have been recorded. The age group 0 - 9 years was 29% and that of >50 years was 11%. The median age of patients was 30 years with a minimum of 1 and a maximum of 78 years. The female gender was more represented at 52.69% than the male gender at 47.31%, i.e. a sex ratio of 0.89 (M/F). Salmonella strains were much more isolated in stools at 62% followed by urines at 29% and blood at 6%. Salmonella arizonae strains were more represented with 52%. Salmonella strains have a resistance rate to Tetracycline of 62.37% followed by Penicillins of 50%. The rate of multi-antibiotic resistance of the Salmonella strains isolated represented 48.38%. Salmonella spp. strains were multi-resistant at

References

[1]  Grimont, P.A.D. and Weill, F.X. (2007) Antigenic Formulas of the Salmonella Serovars. 9th Edition, World Health Organization, Paris, 167 p.
[2]  Dawoud, T., Shi, Z., Kwon, Y. and Ricke, S. (2017) Overview of Salmonellosis and Food-Borne Salmonella. In: Ricke, S.C. and Gast, R.K., Eds., Producing Safe Eggs, Academic Press, Cambridge, 113-138.
https://doi.org/10.1016/B978-0-12-802582-6.00007-0
[3]  WHO (2021) Food Safety: Announcing New Coalitions at the UN Food Systems Summit to Expand Access to Sustainable Food on September 23, 2021. World Health Organization, New York.
https://www.who.int/
[4]  Pang, T., Bhutta, A.Z.A., Finlay, B.B. and Altwegg, M. (1995) Typhoid Fever and Other Salmonellosis: A Continuing Challenge. Trends in Microbiology, 3, 253-255.
https://doi.org/10.1016/S0966-842X(00)88937-4
[5]  Hu, L. and Kopecko, D. (2002) Salmonella typhi and Paratyphi. In: Sussman, M., Ed., Molecular Medical Microbiology (Volume 2), Academic Press, London, 1365-1391.
https://doi.org/10.1016/B978-012677530-3/50285-3
[6]  Feasey, N.A., Dougan, G., Kingsley, R.A., Heyderman, R.S. and Gordon, D.M.A. (2012) Invasive Non-Typhoidal Salmonella Disease: An Emerging and Neglected Tropical Disease in Africa. The Lancet, 379, 2489-2499.
https://doi.org/10.1016/S0140-6736(11)61752-2
[7]  Wadula, J., Von Gottberg, A., Kilner, D., De Jong, G., Cohen, C., et al. (2006) Nosocomial Outbreak of Extended-Spectrum β-Lactamase-Producing Salmonella Using in Pediatric Wards. The Pediatric Infectious Disease Journal, 25, 843-844.
https://doi.org/10.1097/01.inf.0000233543.78070.a2
[8]  Beyene, G., Nair, S., Asrat, D., Mengistu, Y., Engers, H. and Wain, J. (2011) Multidrug-Resistant Salmonella Concord Is a Major Cause of Salmonellosis in Children in Ethiopia. The Journal of Infection in Developing Countries, 5, 23-33.
https://doi.org/10.3855/jidc.906
[9]  Tennant, S.M., Diallo, S., Levy, H., Livio, S., Sow, S.O., Tapia, M., Fields, P.I., Mikoleit, M., Tamboura, B., Kotloff, K.L., Nataro, J.P., Galen, J.E. and Levine, M.M. (2010) Identification by PCR of Non-Typhoidal Salmonella enterica Serovars Associated with Invasive Infections among Febrile Patients in Mali. PLOS Neglected Tropical Diseases, 4, e621.
https://doi.org/10.1371/journal.pntd.0000621
[10]  Santillana Farakos, S.M., Schaffner, D.W. and Frank, J.F. (2014) Predicting Survival of Salmonella in Low-Water Activity Foods: An Analysis of Literature Data. Journal of Food Protection, 77, 1448-1461.
https://doi.org/10.4315/0362-028X.JFP-14-013
[11]  Popoff, M.Y., Bockemühl, J. and Gheesling, L.L. (2001) Supplement 2001 (No. 45) to the Kauffmann-White Scheme. Research in Microbiology, 154, 173-174.
https://doi.org/10.1016/S0923-2508(03)00025-1
[12]  Public Health France (2023) Antibiotic Resistance. 91 p.
https://www.santepubliquefrance.fr/
[13]  Health Canada (2005) Préventionde la salmonellose.
https://www.gov.mb.ca/
[14]  Malle, A. (2007) Monitoring Antimicrobial Resistance of Salmonella Strains Isolated at the Rodolphe Mérieux Laboratory from 2015 to 2017 at the MRL in Bamako/Mali.
https://www.amazon.com/
[15]  Réné, D., Konaté, A., Traoré, O., Kaboré, W.A.D., Soulama, I., Kagambèga, A., et al. (2020) Extended-Spectrum β-Lactamase and Fluoroquinolone Resistance Genes among Escherichia coli and Salmonella Isolates from Children with Diarrhea, Burkina Faso. BMC Pediatrics, 20, Article No. 459.
https://doi.org/10.1186/s12887-020-02342-z
[16]  Tastevin, P., Levy Hara, G., Toumi, A., Enani, M., Coombs, G., Voss, A., et al. (2020) Advocacy for Increased International Efforts for Antimicrobial Stewardship Actions in Low-Middle-Income Countries on Behalf of Alliance for the Prudent Use of Antimicrobials (APUA), under the Auspices of the International Society of Antimicrobial Chemotherapy (ISAC). Frontiers in Medicine, 7, Article 527243.
https://doi.org/10.3389/fmed.2020.00503
[17]  Tadesse, B.T., Ashley, E.A., Ongarello, S., Havumaki, J., Wijegoonewardena, M., González, I.J., et al. (2017) Antimicrobial Resistance in Africa: A Systematic Review. BMC Infectious Diseases, 17, Article No. 616.
https://doi.org/10.1186/s12879-017-2713-1
[18]  Georges, A., Lesbordes, J.L., Meunier, D.M.Y., Beuzit, Y., Taillefer, C. and Georges, M.C. (1984) Bacteriological and Clinical Aspects of S. Typhi Infections in the Central African Republic. Bulletin de la Societe de Pathologie Exotique, 77, 164-174.
[19]  Georges-Courbot, M.C., Baya, C. and Georges, A.J. (1984) Serotypes, Lysotypes and Antibiotypes of 127 Strains of Salmonella Isolated in the Central African Republic. Bulletin de la Societe de Pathologie Exotique, 77, 158-163.
[20]  Georges-Courbot, M.C., Meunier, D.M.Y., Lesbordes, J.L., Ramiara, J.P., Bouquety, J.C., Siopathis, R.M., et al. (1988) Epidemiological Aspects of Typhoid Fever in Bangui (Central African Republic). Médecine d’Afrique Noire, 35, 263-271.
[21]  Mossoro-Kpinde, C.D., Lango-Yaya, E., Yandoumba, M., Nambei, S.W., Koffi, B. and Le Faou, A. (2012) Antibiotic Susceptibility of Salmonella Serotypes Typhi, Paratyphi A, B and C la à Bangui. Médecine d’Afrique Noire, 59, 183-185.
[22]  Lango-Yaya, E., Djeintote, M., Djimeli, C.L., kpinde, C.M., Nambei, W.S., et al. (2017) Contribution to the Study of Antibiotic Resistance on Salmonella and Shigella Strains Isolated in Central African Republic. Journal of Microbiology & Experimentation, 4, Article ID: 00105.
[23]  Hoorfar, D. and Baggesen, D.L. (1988) Importance of Pre-Enrichment Media for Isolation of Salmonella spp. from Swine and Poultry. FEMS Microbiology Letters, 169, 125-130.
https://doi.org/10.1111/j.1574-6968.1998.tb13308.x
[24]  Singer, R.S, Mayer, A., Hanson, T.E. and Isaacson, R.E. (2009) Domicrobial Interactions and Cultivation Media Decrease the Accuracy of Salmonella Surveillance Systems and Outbreak Investigations? Journal of Food Protection, 72, 707-713.
https://doi.org/10.4315/0362-028X-72.4.707
[25]  Langendorf, C., Le Hello, S., Moumouni, A., Gouali, M., Mamaty, A.A., Grais, R.F., et al. (2015) Enteric Bacterial Pathogens in Children with Diarrhea in Niger: Diversity and Antimicrobial Resistance. PLOS ONE, 10, e0120275.
https://doi.org/10.1371/journal.pone.0120275
[26]  Kwambana-Adams, B., Darboe, S., Nabwera, H., Foster-Nyarko, E., Ikumapayi, U.N., Secka, O., Betts, M., Bradbury, R., Wegmüller, R., Lawal, B., Saha, D., Hossain, M.J., Prentice, A.M., Kampmann, B., Anderson, S., Dalessandro, U. and Antonio, M. (2015) Salmonella Infections in The Gambia, 2005-2015. Clinical Infectious Diseases, 61, S354-S362.
https://doi.org/10.1093/cid/civ781
[27]  Vandenberg, O., Nyarukweba, D.Z., Ndeba, P.M., Hendriksen, R.S., Barzilay, E.J., Schirvel, C., Bisimwa, B.B., Collard, J.M., Aidara, K.A. and Aarestrup, F.M. (2010) Microbiologic and Clinical Features of Salmonella Species Isolated from Bacteremic Children in Eastern Democratic Republic of Congo. Pediatric Infectious Diseases Journal, 29, 504-510.
https://doi.org/10.1097/INF.0b013e3181cd615a
[28]  Kariuki, S., Revathi, G., Kiiro, J., Lowe, B., Berkley, J.A. and Hart, C.A. (2006) Decreasing Prevalence of Antimicrobial Resistance in NTS Isolated from Children with Bacteremia in a Rural District Hospital, Kenya. International Journal of Antimicrobial Agents, 28, 166-171.
https://doi.org/10.1016/j.ijantimicag.2006.05.026
[29]  Delmas, G., Jourdan-Da Silva, N., Pihier, N., Weill, F.X., Vaillant, V. and De Valk, H. (2010) Les Toxi-Infections Alimentaires Collectives en France Entre 2006-2008. Bulletin Epidémiologique Hebdomadaire, 31-32, 344-348.
[30]  Salim, A.M. and Omar, A. (2020) Frequence des infections à Salmonella spp. chez l’Homme au niveau de l’hopital Djilali belkhenchir (ex birtraria) AlgerSalm.
https://di.univ-blida.dz/
[31]  Wesley, M., Ceyssens, P.-J., Van Den Bossche, A.N. and Centre National de Référence Salmonella (2022) Rapport Annuel 2022 Salmonella & Shigella Juillet 2023.
[32]  Kanj, S.S., Kanafani, Z.A., Shehab, M., Sidani, N., Baban, T., Baltajian, K., et al. (2015) Epidemiology, Clinical Manifestations, and Molecular Typing of Salmonella typhi Isolated from Patients with Typhoid Fever in Lebanon. Journal of Epidemiology and Global Health, 5, 159-165.
https://doi.org/10.1016/j.jegh.2014.07.003
http://linkinghub.elsevier.com/retrieve/pii/S2210600614000744
Sawadogo Néhémie, M. (2023) Evaluation de la résistance aux antibiotiques des souches de Salmonella spp. isolées des selles et du sang chez les patients à Bamako. Master’s Thesis, Université des Sciences, des Techniques et des Technologies de Bamako (USTTB), Bamako.
[33]  Sounkarou, T. (2013) Typage des Souches de Salmonella isolées au Laboratoire De Bactériologie CVD du Chu Gabriel Toure de Janvier 2011 à Juillet 2013. Ph.D. Thesis, Université des Sciences, des Techniques et des Technologies de Bamako, Bamako.
[34]  Andoh, L.A., Dalsgaard, A., Obiri-danso, K., Newman, M.J., Barco, L. and Olsen, J.E. (2016) Prevalence and Antimicrobial Resistance of Salmonella Serovars Isolated from Poultry in Ghana. Epidemiology & Infection, 144, 3288-3299.
[35]  Abba, H., Somda, M., Barro, N., Traore, A. and Bebanto, B. (2017) Prévalence et susceptibilité aux antibiotiques des souches de Salmonella spp. non typhiques isolées de la viande de poulets au Tchad. International Journal of Biological and Chemical Sciences, 11, 107-117.
https://doi.org/10.4314/ijbcs.v11i1.9
[36]  Novick, R. (1981) The Development and Spread of Antibiotic-Resistant Bacteria as a Consequence of Feeding Antibiotics to Livestock. Annals of the New York Academy of Sciences, 368, 23-60.
https://doi.org/10.1111/j.1749-6632.1981.tb15430.x
[37]  Kasper, M.R., Sokhal, B., Blair, P.J., Wierzba, T.F. and Putnam, S.D. (2010) The Emergence of Multidrug-Resistant Salmonella enterica Serovar Typhi with Reduced Susceptibility to Fluoroquinolones in Cambodia. Diagnostic Microbiology and Infectious Disease, 66, 207-209.
http://www.sciencedirect.com/science/article/pii/S0732889309003654
https://doi.org/10.1016/j.diagmicrobio.2009.09.002
[38]  Stanaway, J.D., Parisi, A., Sarkar, K., et al. (2019) The Global Burden of Non-Typhoidal Salmonella Invasive Disease: A Systematic Analysis for the Global Burden of Disease Study 2017 Neglected Tropical Disease in Africa. Lancet, 372, 2489-2499.

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