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肝血管瘤介入治疗的应用进展
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Abstract:
肝血管瘤(Hepatic hemangiomas, HHs)是成人肝脏最常见的良性肿瘤之一,包括海绵状血管瘤、上皮样血管内皮瘤以及血管肉瘤,其中以海绵状血管瘤最常见,多为良性肿瘤且无症状,一般不需要治疗。但也有特殊情况需要治疗干预,目前手术是主要的治疗方式。尽管微创技术的发展和普及取得了重大进展,但介入治疗因其创伤小、恢复快以及预后好等优点,仍是肝血管瘤不可或缺的治疗手段。本综述旨在讨论肝血管瘤的病理性质、血供类型、治疗指征,以及介入治疗的现状和进展。
Hepatic hemangiomas (HHs) is one of the most common tumors in adult liver, including cavernous hemangiomas, epithelioid hemangioendotheliomas and angiosarcomas. Cavernous hemangioma is the most common, mostly benign and asymptomatic, and generally does not need treatment. How-ever, there are also special circumstances that require treatment and intervention, and surgery is the main treatment at present. Although great progress has been made in the development and popularization of minimally invasive technology, interventional therapy is still an indispensable treatment for hepatic hemangioma because of its advantages such as less trauma, rapid recovery and good prognosis. The purpose of this review is to discuss the pathological nature, blood supply type, treatment indication, current situation and progress of interventional therapy of hepatic he-mangioma.
[1] | Choi, B.Y. and Nguyen, M.H. (2005) The Diagnosis and Management of Benign Hepatic Tumors. Journal of Clinical Gastroenterology, 39, 401-412. https://doi.org/10.1097/01.mcg.0000159226.63037.a2 |
[2] | Ishak, K.G. and Rabin, L. (1975) Benign Tumors of the Liver. Medical Clinics of North America, 59, 995-1013.
https://doi.org/10.1016/S0025-7125(16)31998-8 |
[3] | Brouwers, M.A., Peeters, P.M., De Jong, K.P., et al. (1997) Surgical Treatment of Giant Haemangioma of the Liver. British Journal of Surgery, 84, 314-316. https://doi.org/10.1046/j.1365-2168.1997.02534.x |
[4] | Mocchegiani, F., Vincenzi, P., Coletta, M., et al. (2016) Prevalence and Clinical Outcome of Hepatic Haemangioma with Specific Reference to the Risk of Rupture: A Large Ret-rospective Cross-Sectional Study. Digestive and Liver Disease, 48, 309-314. https://doi.org/10.1016/j.dld.2015.09.016 |
[5] | European Association for the Study of the Liver (EASL) (2016) EASL Clinical Practice Guidelines on the Management of Benign Liver Tumours. Journal of Hepatology, 65, 386-398. https://doi.org/10.1016/j.jhep.2016.04.001 |
[6] | Roebuck, D., Sebire, N., Lehmann, E. and Barnacle, A. (2012) Rapidly Involuting Congenital Haemangioma (RICH) of the Liver. Pediatric Radiology, 42, 308-314. https://doi.org/10.1007/s00247-011-2268-z |
[7] | Glinkova, V., Shevah, O., Boaz, M., Levine, A. and Shirin, H. (2004) Hepatic Haemangiomas: Possible Association with Female Sex Hormones. Gut, 53, 1352-1355. https://doi.org/10.1136/gut.2003.038646 |
[8] | Baker, E.R., Manders, E. and Whitney, C.W. (1985) Growth of Cavernous Hemangioma with Puberty. Clinical Pediatrics, 24, 596-598. https://doi.org/10.1177/000992288502401010 |
[9] | Castaneda-Zuniga, W.R. (1997) Interventional Radiology. 3rd Edition, Williams & Wilkins, Baltimore. |
[10] | 欧阳墉, 王颖, 欧阳雪晖, 等. 肝海绵状血管瘤血供和介入治疗的争议和探讨[J]. 中华放射学杂志, 2004, 38(7): 746-750. |
[11] | Goodman, Z.D. and Terraciano, L.M. (2007) Tumours and Tumour-Like Lesions of the Liver. In: Burt, A.D., Portmann, B.C. and Ferrell, L.D., Eds., Mac Sween’s Pathology of the Liver (5th Edition), Churchill Livingstone, Oxford, 761-814. |
[12] | Bioulac-Sage, P., Laumonier, H., Laurent, C., Blanc, J.F. and Balabaud, C. (2008) Benign and Malignant Vascular Tumors of the Liver in Adults. Seminars in Liver Disease, 28, 302-314. https://doi.org/10.1055/s-0028-1085098 |
[13] | Moctezuma-Velazquez, C., Lopez-Arce, G., Mar-tínez-Rodríguez, LA., et al. (2014) Giant Hepatic Hemangioma versus Conventional Hepatic Hemangioma: Clinical Findings, Risk Factors, and Management. Revista de Gastroenterología de México, 79, 229-237. https://doi.org/10.1016/j.rgmxen.2014.12.004 |
[14] | Herman, P., Costa, M.L., Machado, M.A., et al. (2005) Man-agement of Hepatic Hemangiomas: A 14-Year Experience. Journal of Gastrointestinal Surgery, 9, 853-859. https://doi.org/10.1016/j.gassur.2005.01.292 |
[15] | Hoekstra, L.T., Bieze, M., Erdogan, D., et al. (2013) Manage-ment of Giant Liver Hemangiomas: An Update. Expert Review of Gastroenterology & Hepatology, 7, 263-268. https://doi.org/10.1586/egh.13.10 |
[16] | 李克雷, 姚伟, 秦中平, 等. Kasabach-Merritt现象诊断与治疗中国专家共识[J]. 中国口腔颌面外科杂志, 2019, 17(2): 97-105. https://doi.org/10.19438/J.Cjoms.2019.02.001 |
[17] | 占大钱, 黄志勇, 赵银峰, 等. 动脉栓塞治疗HH系统分析[J]. 华中科技大学学报(医学版), 2011, 40(5): 623-625, 629. |
[18] | Abdel Wahab, M., El Nakeeb, A., Ali, M.A., et al. (2018) Surgical Management of Giant Hepatic Hemangio-ma: Single Center’s Experience with 144 Patients. Journal of Gastrointestinal Surgery, 22, 849-858.
https://doi.org/10.1007/s11605-018-3696-y |
[19] | 陈孝平, 夏锋, 李雪松. HH诊断和治疗多学科专家共识(2019版) [J]. 临床肝胆病杂志, 2019, 35(9): 1928-1932. |
[20] | Toro, A., Mahfouz, A.E., Ardiri, A., et al. (2014) What Is Changing in Indications and Treatment of Hepatic Hemangiomas. A Review. Annals of Hepatology, 13, 327-339. https://doi.org/10.1016/S1665-2681(19)30839-7 |
[21] | Yedibela, S., Alibek, S., Müller, V., et al. (2013) Manage-ment of Hemangioma of the Liver: Surgical Therapy or Observation? World Journal of Surgery, 37, 1303-1312. https://doi.org/10.1007/s00268-013-1904-1 |
[22] | Cho, S.H., Kang, U.R., Kim, J.D., et al. (2011) The Value of Gadoxetate Disodium-Enhanced MR Imaging for Predicting Posthepatectomy Liver Failure after Major Hepatic Resec-tion: A Preliminary Study. European Journal of Radiology, 80, E195-E200. https://doi.org/10.1016/j.ejrad.2011.08.008 |
[23] | Sirli, R., Sporea, I., Popescu, A., et al. (2011) Contrast Enhanced Ultrasound for the Diagnosis of Liver Hemangiomas in Clinical Practice. Medical Ultrasonography, 13, 95-101. |
[24] | Qiu, J., Chen, S. and Wu, H. (2015) Quality of Life Can Be Improved by Surgical Management of Giant Hepatic Haemangioma with Enucleation as the Preferred Option. HPB, 17, 490-494. https://doi.org/10.1111/hpb.12391 |
[25] | Xia, F., Lau, W.Y., Qian, C., et al. (2010) Surgical Treatment of Giant Liv-er Hemangiomas: Enucleation with Continuous Occlusion of Hepatic Artery Proper and Intermittent Pringle Maneuver. World Journal of Surgery, 34, 2162- 2167. https://doi.org/10.1007/s00268-010-0592-3 |
[26] | Cobey, F.C. and Sa-lem, R.R. (2004) A Review of Liver Masses in Pregnancy and a Proposed Algorithm for Their Diagnosis and Manage-ment. The American Journal of Surgery, 187, 181-191.
https://doi.org/10.1016/j.amjsurg.2003.11.016 |
[27] | Dong, W., Qiu, B., Xu, H. and He, L. (2019) Invasive Man-agement of Symptomatic Hepatic Hemangioma. European Journal of Gastroenterology & Hepatology, 31, 1079-1084. https://doi.org/10.1097/MEG.0000000000001413 |
[28] | Liu, X., Yang, Z., Tan, H., et al. (2017) Long-Term Result of Transcatheter Arterial Embolization for Liver Hemangioma. Medicine, 96, e9029. https://doi.org/10.1097/MD.0000000000009029 |
[29] | Sun, J.H., Nie, C.H., Zhang, Y.L., et al. (2015) Transcatheter Arterial Embolization Alone for Giant Hepatic Hemangioma. PLOS ONE, 10, e0135158. https://doi.org/10.1371/journal.pone.0135158 |
[30] | Jia, K.F., Yu, C.L., Sun, C., et al. (2018) Analysis of the Effects and Complications of Interventional Treatment of Hepatic Hemangioma with Different Blood Supply Characteristics. Chinese Journal of Hepatobiliary Surgery, 24, 145- 149. |
[31] | Fan, S.L., Tong, X.Q., Wang, J., et al. (2013) Selective Treatment of Giant Hepatic Hemangioma with Hepatic Artery Embolization in 46 Cases. World Chinese Journal of Di-gestology, 1925-1930.
https://doi.org/10.11569/wcjd.v21.i20.1925 |
[32] | 郑贝贝, 任芳芳, 郑莹莹. 肝动脉栓塞介入术治疗不同血供类型HH的临床观察[J]. 实用癌症杂志, 2022, 37(12): 2050-2053. |
[33] | 孙力波, 赵晓飞, 张海涛, 等. 射频消融治疗肝血管瘤的效果观察[J]. 临床肝胆病杂志, 2017, 33(1): 91-94. |
[34] | 吴珍宝, 王苏丹, 汪长青, 等. 腹腔镜下微波消融治疗肝血管瘤的临床研究[J]. 中国普通外科杂志, 2015, 24(7): 996-1000. |
[35] | Ayoobi Yazdi, N., Mehrabinejad, M.M., Dashti, H., Pourghorban, R., Nassiri Toosi, M. and Rokni Yazdi, H. (2021) Percutaneous Sclero-therapy with Bleomycin and Ethiodized Oil: A Promising Treatment in Symptomatic Giant Liver Hemangioma. Radiology, 301, 464-471. https://doi.org/10.1148/radiol.2021204444 |
[36] | 王智强. 肝脏恶性肿瘤氩氦刀冷冻消融治疗后早期MRI成像特点研究[D]: [硕士学位论文]. 长春: 吉林大学, 2022. |
[37] | Silverman, S.G., Tuncali, K., Adams, D.F., et al. (2000) MR Imaging-Guided Percutaneouscryotherapy of Liver Tumors: Initial Experience. Radiology, 217, 657-664. https://doi.org/10.1148/radiology.217.3.r00dc40657 |