Eating disorders are among the deadliest mental
illnesses known to occur. Eating disorders directly cause 10,200 deaths each
year, which is one deathevery 52
minutes. About 9% of the global population is affected by eating disorders at some point during their lifetime. This paper aims to
provide a better understanding of the factors
that contribute to the onset of eating disorders.Specifically, we examine biological factors, such
as genetics, family history and the
neuroscience behind eating disorders; furthermore, we explore psychological
factors including other mental health conditions and their correlation,
personality traits and behavioral risk factors; lastly, we consider social
factors related to the onset of eating
disorders, such as childhood and social environment, the media, and demographic factors.
References
[1]
Crone, C., Fochtmann, L.J., Attia, E., Boland, R., Escobar, J., Fornari, V. and Medicus, J. (2023) The American Psychiatric Association Practice Guideline for the Treatment of Patients with Eating Disorders. American Journal of Psychiatry, 180, 167-171. https://doi.org/10.1176/appi.ajp.23180001
[2]
American Psychiatric Association (2013) Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition: DSM-5. American Psychiatric Association, Arlington. https://doi.org/10.1176/appi.books.9780890425596
[3]
Marie, G., Pierre, D., Grégory, L. and Pierre, T.M. (2019) Prevalence of Eating Disorders over the 2000-2018 Period: A Systematic Literature Review. The American Journal of Clinical Nutrition, 109, 1402-1413. https://doi.org/10.1093/ajcn/nqy342
[4]
Bulik, C.M. and Tozzi, F. (2004) Genetics in Eating Disorders: State of the Science. CNS Spectrums, 9, 511-515. https://doi.org/10.1017/S1092852900009597
[5]
Ocklenburg, S. (2019) The Serotonin Transporter Gene and Depression. Psychology Today. https://www.psychologytoday.com/us/blog/the-asymmetric-brain/201905/the-serotonin-transporter-gene-and-depression
[6]
Trace, S.E., Baker, J.H., Penas-Lledó, E. and Bulik, C.M. (2013) The Genetics of Eating Disorders. Annual Review of Clinical Psychology, 9, 589-620. https://doi.org/10.1146/annurev-clinpsy-050212-185546
[7]
Yadav, V.K., Oury, F., Suda, N., Liu, Z.W., Gao, X.B., Confavreux, C. and Karsenty, G. (2009) A Serotonin-Dependent Mechanism Explains the Leptin Regulation of Bone Mass, Appetite, and Energy Expenditure. Cell, 138, 976-989. https://doi.org/10.1016/j.cell.2009.06.051
[8]
Schorr, M. and Miller, K.K. (2017) The Endocrine Manifestations of Anorexia Nervosa: Mechanisms and Management. Nature Reviews Endocrinology, 13, 174-186. https://doi.org/10.1038/nrendo.2016.175
[9]
Zou, X.H., et al. (2019) Role of Leptin in Mood Disorder and Neurodegenerative Disease. Frontiers in Neuroscience, 13, Article 378. https://doi.org/10.3389/fnins.2019.00378
[10]
Sodersten, P., Bergh, C., Leon, M. and Zandian, M. (2016) Dopamine and Anorexia Nervosa. Neuroscience & Biobehavioral Reviews, 60, 26-30. https://doi.org/10.1016/j.neubiorev.2015.11.003
[11]
Pirke, K.M. (1996) Central and Peripheral Noradrenaline Regulation in Eating Disorders. Psychiatry Research, 62, 43-49. https://doi.org/10.1016/0165-1781(96)02982-4
[12]
Song, W., Wang, W., Yu, S. and Lin, G.N. (2021) Dissection of the Genetic Association between Anorexia Nervosa and Obsessive-Compulsive Disorder at the Network and Cellular Levels. Genes, 12, Article 491. https://doi.org/10.3390/genes12040491
[13]
Bamford, I.J. and Bamford, N.S. (2019) The Striatum’s Role in Executing Rational and Irrational Economic Behaviors. The Neuroscientist, 25, 475-490. https://doi.org/10.1177/1073858418824256
[14]
Bulik, C.M., Coleman, J.R., Hardaway, J.A., Breithaupt, L., Watson, H.J., Bryant, C.D. and Breen, G. (2022) Genetics and Neurobiology of Eating Disorders. Nature Neuroscience, 25, 543-554. https://doi.org/10.1038/s41593-022-01071-z
[15]
Ting, J.T. and Feng, G. (2011) Neurobiology of Obsessive-Compulsive Disorder: In-Sights into Neural Circuitry Dysfunction through Mouse Genetics. Current Opinion in Neurobiology, 21, 842-848. https://doi.org/10.1016/j.conb.2011.04.010
[16]
Zhu, Y., Jiang, X. and Ji, W. (2018) The Mechanism of Cortico-Striato-Thalamo-Cortical Neurocircuitry in Response Inhibition and Emotional Responding in Attention Deficit Hyperactivity Disorder with Comorbid Disruptive Behavior Disorder. Neuroscience Bulletin, 34, 566-572. https://doi.org/10.1007/s12264-018-0214-x
[17]
Hudson, J.I., Hiripi, E., Pope Jr., H.G. and Kessler, R.C. (2007) The Prevalence and Correlates of Eating Disorders in the National Comorbidity Survey Replication. Biological Psychiatry, 61, 348-358. https://doi.org/10.1016/j.biopsych.2006.03.040
[18]
Udo, T. and Grilo, C.M. (2019) Psychiatric and Medical Correlates of DSM-5 Eating Disorders in a Nationally Representative Sample of Adults in the United States. International Journal of Eating Disorders, 52, 42-50. https://doi.org/10.1002/eat.23004
[19]
Smith, A.R., Zuromski, K.L. and Dodd, D.R. (2018) Eating Disorders and Suicidality: What We Know, What We Don’t Know, and Suggestions for Future Research. Current Opinion in Psychology, 22, 63-67. https://doi.org/10.1016/j.copsyc.2017.08.023
[20]
Stoeber, J. (2018) The Psychology of Perfectionism: Critical Issues, Open Questions, and Future Directions. Routledge, London. https://doi.org/10.4324/9781315536255-4
[21]
Fairburn, C.G., Shafran, R. and Cooper, Z. (1999) A Cognitive Behavioural Theory of Anorexia Nervosa. Behaviour Research and Therapy, 37, 1-13. https://doi.org/10.1016/S0005-7967(98)00102-8
[22]
Halmi, K.A., Sunday, S.R., Strober, M., Kaplan, A., Woodside, D.B., Fichter, M. and Kaye, W.H. (2000) Perfectionism in Anorexia Nervosa: Variation by Clinical Sub-Type, Obsessionality, and Pathological Eating Behavior. American Journal of Psychiatry, 157, 1799-1805. https://doi.org/10.1176/appi.ajp.157.11.1799
[23]
Hewitt, P.L., Flett, G.L. and Ediger, E. (1996) Perfectionism and Depression: Longitudinal Assessment of a Specific Vulnerability Hypothesis. Journal of Abnormal Psychology, 105, 276-280. https://doi.org/10.1037/0021-843X.105.2.276
[24]
Boone, L., Soenens, B. and Luyten, P. (2014) When or Why Does Perfectionism Trans-Late into Eating Disorder Pathology? A Longitudinal Examination of the Moderating and Mediating Role of Body Dissatisfaction. Journal of Abnormal Psychology, 123, 412-418. https://doi.org/10.1037/a0036254
[25]
Dawe, S. and Loxton, N.J. (2004) The Role of Impulsivity in the Development of Sub-Stance Use and Eating Disorders. Neuroscience & Biobehavioral Reviews, 28, 343-351. https://doi.org/10.1016/j.neubiorev.2004.03.007
[26]
Culbert, K.M., Racine, S.E. and Klump, K.L. (2016) Hormonal Factors and Disturbances in Eating Disorders. Current Psychiatry Reports, 18, Article No. 65. https://doi.org/10.1007/s11920-016-0701-6
[27]
Devlin, B., Bacanu, S.A., Klump, K.L., Bulik, C.M., Fichter, M.M., Halmi, K.A. and Kaye, W.H. (2002) Linkage Analysis of Anorexia Nervosa Incorporating Behavioral Covariates. Human Molecular Genetics, 11, 689-696. https://doi.org/10.1093/hmg/11.6.689
[28]
Koren, R., Munn-Chernoff, M.A., Duncan, A.E., Bucholz, K.K., Madden, P.A., Heath, A.C. and Agrawal, A. (2014) Is the Relationship between Binge Eating Episodes and Personality Attributable to Genetic Factors? Twin Research and Human Genetics, 17, 65-71. https://doi.org/10.1017/thg.2013.92
[29]
Roberts, M.E., Tchanturia, K., Stahl, D., Southgate, L. and Treasure, J. (2007) A Systematic Review and Meta-Analysis of Set-Shifting Ability in Eating Disorders. Psychological Medicine, 37, 1075-1084. https://doi.org/10.1017/S0033291707009877
[30]
Claes, L., Mitchell, J.E. and Vandereycken, W. (2012) Out of Control? Inhibition Processes in Eating Disorders from a Personality and Cognitive Perspective. International Journal of Eating Disorders, 45, 407-414. https://doi.org/10.1002/eat.20966
[31]
Marsh, R., Horga, G., Wang, Z., Wang, P., Klahr, K.W., Berner, L.A. and Peterson, B.S. (2011) An FMRI Study of Self-Regulatory Control and Conflict Resolution in Adolescents with Bulimia Nervosa. American Journal of Psychiatry, 168, 1210-1220. https://doi.org/10.1176/appi.ajp.2011.11010094
[32]
Liu, L.J., et al. (2021) The Effect of Selective Serotonin Reuptake Inhibitors on Cognitive Impairment in Patients with Depression: A Prospective, Multicenter, Observational Study. Journal of Psychiatric Research, 141, 26-33. https://doi.org/10.1016/j.jpsychires.2021.06.020
[33]
Uddin, L.Q. (2021) Cognitive and Behavioural Flexibility: Neural Mechanisms and Clinical Considerations. Nature Reviews Neuroscience, 22, 167-179. https://doi.org/10.1038/s41583-021-00428-w
[34]
Franko, D.L., Thompson, D., Affenito, S.G., Barton, B.A. and Striegel-Moore, R.H. (2008) What Mediates the Relationship between Family Meals and Adolescent Health Issues. Health Psychology, 27, S109-S117. https://doi.org/10.1037/0278-6133.27.2(Suppl.).S109
[35]
Back, E.A. (2011) Effects of Parental Relations and Upbringing in Troubled Adolescent Eating Behaviors. Eating Disorders, 19, 403-424. https://doi.org/10.1080/10640266.2011.609091
[36]
Bartholomew, K. and Horowitz, L.M. (1991) Attachment Styles among Young Adults: A Test of a Four-Category Model. Journal of Personality and Social Psychology, 61, 226-244. https://doi.org/10.1037/0022-3514.61.2.226
[37]
Sharpe, T.M., Killen, J.D., Bryson, S.W., Shisslak, C.M., Estes, L.S., Gray, N. and Taylor, C.B. (1998) Attachment Style and Weight Concerns in Preadolescent and Adolescent Girls. International Journal of Eating Disorders, 23, 39-44. https://doi.org/10.1002/(SICI)1098-108X(199801)23:1<39::AID-EAT5>3.0.CO;2-2
[38]
Saiphoo, A.N. and Vahedi, Z. (2019) A Meta-Analytic Review of the Relationship between Social Media Use and Body Image Disturbance. Computers in Human Behavior, 101, 259-275. https://doi.org/10.1016/j.chb.2019.07.028
[39]
Harriger, J.A., Evans, J.A., Thompson, J.K. and Tylka, T.L. (2022) The Dangers of the Rabbit Hole: Reflections on Social Media as a Portal into a Distorted World of Edited Bodies and Eating Disorder Risk and the Role of Algorithms. Body Image, 41, 292-297. https://doi.org/10.1016/j.bodyim.2022.03.007
[40]
Karsay, K., Trekels, J., Eggermont, S. and Vandenbosch, L. (2021) “I (Don’t) Respect My Body”: Investigating the Role of Mass Media Use and Self-Objectification on Adolescents’ Positive Body Image in a Cross-National Study. Mass Communication and Society, 24, 57-84. https://doi.org/10.1080/15205436.2020.1827432
[41]
Nasser, M. (2009) Eating Disorders across Cultures. Psychiatry, 8, 347-350. https://doi.org/10.1016/j.mppsy.2009.06.009
[42]
Mitchison, D., Hay, P., Slewa-Younan, S. and Mond, J. (2014) The Changing Demo- Graphic Profile of Eating Disorder Behaviors in the Community. BMC Public Health, 14, Article No. 943. https://doi.org/10.1186/1471-2458-14-943
[43]
Strother, E., Lemberg, R., Stanford, S.C. and Turbeville, D. (2012) Eating Disorders in Men: Undergdiagnosed, Undertreated, and Misunderstood. Eating Disorders, 20, 346-355. https://doi.org/10.1080/10640266.2012.715512
[44]
Gibbons, P. (2001) The Relationship between Eating Disorders and Socioeconomic Status: It’s Not What You Think. Nutrition Noteworthy, 4, 3.
