|
|
2型糖尿病合并亚临床甲减对心血管疾病影响的研究进展
|
Abstract:
2型糖尿病(T2DM)和亚临床甲减(SCH)是两种常见的慢性疾病。近年来研究发现，T2DM合并SCH患者在临床中并不少见，且此类患者罹患心血管疾病的风险显著增加。本文旨在围绕T2DM合并SCH对心血管疾病影响的研究进展展开综述，一方面提高我们对这两种疾病的理解，另一方面，为临床提供更有效的预防和治疗策略。
Type 2 diabetes (T2DM) and subclinical hypothyroidism (SCH) are two common chronic conditions. In recent years, studies have found that patients with T2DM combined with SCH are not uncommon in clinical practice, and such patients have a significantly increased risk of cardiovascular disease. The purpose of this article is to review the research progress on the effect of T2DM combined with SCH on cardiovascular disease, on the one hand, to improve our understanding of these two diseases, on the other hand, to provide more effective prevention and treatment strategies for clinical.
| [1] | Rong, F., Dai, H., Wu, Y., et al. (2021) Association between Thyroid Dysfunction and Type 2 Diabetes: A Meta-Analysis of Prospective Observational Studies. BMC Medicine, 19, Article No. 257.
https://doi.org/10.1186/s12916-021-02121-2 |
| [2] | Jimoh, A.K., Ghazali, M.S., Ogundeji, O.A., et al. (2022) Spectrum of Thyroid Function Test among Type 2 Diabetic Patients Attending a Rural Health Facility, Southwest Nigeria: A Hospital-Based Study. SAGE Open Medicine, 10.
https://doi.org/10.1177/20503121221097625 |
| [3] | Rosengren, A. and Dikaiou, P. (2023) Cardiovascular Outcomes in Type 1 and Type 2 Diabetes. Diabetologia, 66, 425-437. https://doi.org/10.1007/s00125-022-05857-5 |
| [4] | Liu, Y., Li, X., Zhu, Y., et al. (2021) Subclinical Hypothyroidism Contributes to Poor Glycemic Control in Patients with Type 2 Diabetes Mellitus, and Ellagic Acid Attenuates Methimazole-Induced Abnormal Glucose Metabolism in Mice Model. Journal of Food Biochemistry, 45, e13753. https://doi.org/10.1111/jfbc.13753 |
| [5] | Kaushik, A. and Agrawal, M. (2023) Relationship between Subclinical Hypothyroidism and the Risk of Cardiovascular Complications. Cureus, 15, e33708. https://doi.org/10.7759/cureus.33708 |
| [6] | Chiovato, L. and Duntas, L.H. (2014) Cardiovascular Risk in Patients with Subclinical Hypothyroidism. European Endocrinology, 10, 157-160. https://doi.org/10.17925/EE.2014.10.02.157 |
| [7] | Ito, M., Kitanaka, A., Arishima, T., et al. (2013) Effect of L-Thyroxine Replacement on Apolipoprotein B-48 in Overt and Subclinical Hypothyroid Patients. Endocrine Journal, 60, 65-71. https://doi.org/10.1507/endocrj.EJ12-0226 |
| [8] | Elgazar, E.H., Esheba, N.E., Shalaby, S.A. and Mohamed, W.F. (2019) Thyroid Dysfunction Prevalence and Relation to Glycemic Control in Patients with Type 2 Diabetes Mellitus. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 13, 2513-2517. https://doi.org/10.1016/j.dsx.2019.07.020 |
| [9] | Yang, W., Jin, C., Wang, H., et al. (2023) Subclinical Hypothy-roidism Increases Insulin Resistance in Normoglycemic People. Frontiers in Endocrinology, 14, Article 1106968. https://doi.org/10.3389/fendo.2023.1106968 |
| [10] | 黄春梅, 钟锦荣, 丘汉忠. 老年T2DM合并亚临床甲状腺功能减退患者发生冠心病的危险因素分析[J]. 中外医学研究, 2019, 17, 14-17. |
| [11] | Gong, N., Gao, C., Chen, X., et al. (2019) Endothelial Function in Patients with Subclinical Hypothyroidism: A Meta-Analysis. Hormone and Metabolic Research, 51, 691-702. https://doi.org/10.1055/a-1018-9564 |
| [12] | Marushchak, M., Vivsiana, I., Musiienko, V., et al. (2022) Subclinical Hypothyroidism as a Contributor to Macrovascular Complications in Patients with Type 2 Diabetes Mellitus. Acta clinica Croatica, 60, 483-495.
https://doi.org/10.20471/acc.2021.60.03.20 |
| [13] | Shrestha, B. and Rai, C.K. (2023) Hypothyroidism among Type 2 Diabetic Patients Visiting Outpatient Department of Internal Medicine of a Tertiary Care Centre: A Descriptive Cross-Sectional Study. Journal of Nepal Medical Association, 61, 325-328. https://doi.org/10.31729/jnma.8130 |
| [14] | Mohammed Hussein, S.M. and Abdelmageed, R.M. (2021) The Rela-tionship between Type 2 Diabetes Mellitus and Related Thyroid Diseases. Cureus, 13, e20697. https://doi.org/10.7759/cureus.20697 |
| [15] | Dimitriadis, G., Parry-Billings, M., Bevan, S., et al. (1997) The Effects of Insulin on Transport and Metabolism of Glucose in Skeletal Muscle from Hyperthyroid and Hypothyroid Rats. Eu-ropean Journal of Clinical Investigation, 27, 475-483. https://doi.org/10.1046/j.1365-2362.1997.1380688.x |
| [16] | Jiang, Q., Sun, L., Lu, Y., et al. (2020) Identification of Related Long Non-Coding RNAs and MRNAs in Subclinical Hypothyroidism Complicated with Type 2 Diabetes by Transcriptome Analysis—A Preliminary Study. Endokrynologia Polska, 71, 213-226. https://doi.org/10.5603/EP.a2020.0025 |
| [17] | Mehalingam, V., Sahoo, J., Bobby, Z. and Vinod, K. (2020) Thyroid Dysfunction in Patients with Type 2 Diabetes Mellitus and Its Association with Diabetic Complications. Journal of Family Medicine and Primary Care, 9, 4277- 4281. https://doi.org/10.4103/jfmpc.jfmpc_838_20 |
| [18] | Asghar, M., Bukhari, S., Ali, G., et al. (2022) Prevalence and Predictors of Thyroid Dysfunction amongst Patients with Type 2 Diabetes Mellitus in Pakistan. Journal of Family Medicine and Primary Care, 11, 2739-2743.
https://doi.org/10.4103/jfmpc.jfmpc_2106_21 |
| [19] | Khassawneh, A.H., Al-Mistarehi, A.H., Zein Alaabdin, A.M., et al. (2020) Prevalence and Predictors of Thyroid Dysfunction among Type 2 Diabetic Patients: A Case-Control Study. International Journal of General Medicine, 13, 803-816. https://doi.org/10.2147/IJGM.S273900 |
| [20] | Sharma, P., Sinha, R., Prasad, A. and Mitra, J.K. (2020) Lack of Association between Poor Glycemic Control in T2DM and Sub-clinical Hypothyroidism. Journal of Thyroid Research, 2020, Article ID: 8121395.
https://doi.org/10.1155/2020/8121395 |
| [21] | Reddy, N., Pradeep, T.V.S., Tirupati, S., et al. (2020) Thyroid Dys-function and Its Association with Microvascular Complications in Patients with Type 2 Diabetes Mellitus in South India. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 14, 615-617. https://doi.org/10.1016/j.dsx.2020.05.005 |
| [22] | Walczak, K. and Sieminska, L. (2021) Obesity and Thyroid Axis. International Journal of Environmental Research and Public Health, 18, Article 9434. https://doi.org/10.3390/ijerph18189434 |
| [23] | Kalra, S., Aggarwal, S. and Khandelwal, D. (2021) Thyroid Dys-function and Dysmetabolic Syndrome: The Need for Enhanced Thyrovigilance Strategies. International Journal of Endocrinology, 2021, Article ID: 9641846.
https://doi.org/10.1155/2021/9641846 |
| [24] | Talwalkar, P., Deshmukh, V. and Bhole, M. (2019) Prevalence of Hypothyroidism in Patients with Type 2 Diabetes Mellitus and Hypertension in India: A Cross-Sectional Observational Study. Diabetes, Metabolic Syndrome and Obesity, 12, 369-376. https://doi.org/10.2147/DMSO.S181470 |
| [25] | Yao, X., Wang, Y., Wang, L., et al. (2022) Expression Patterns of Serum MicroRNAs Related to Endothelial Dysfunction in Patients with Subclinical Hypothyroidism. Frontiers in En-docrinology, 13, Article 981622.
https://doi.org/10.3389/fendo.2022.981622 |
| [26] | Sue, L.Y. and Leung, A.M. (2020) Levothyroxine for the Treat-ment of Subclinical Hypothyroidism and Cardiovascular Disease. Frontiers in Endocrinology, 11, Article 591588. https://doi.org/10.3389/fendo.2020.591588 |
| [27] | Kalra, S., Aggarwal, S. and Khandelwal, D. (2019) Thyroid Dysfunction and Type 2 Diabetes Mellitus: Screening Strategies and Implications for Management. Diabetes Therapy, 10, 2035-2044.
https://doi.org/10.1007/s13300-019-00700-4 |
