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川崎病基因易感性及临床诊断中的生物标志物
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Abstract:
川崎病是一种急性、自限性的全身血管炎症综合征，主要影响5岁以下婴幼儿，现已成为儿童后天获得性心脏病的最主要原因，其中最严重的并发症是冠状动脉病变，可导致冠状动脉扩张、心肌梗死及猝死。因此早期诊断尤其重要，可以有效降低患儿冠状动脉病变发生率。近年来对川崎病早期诊断的生物标志物开展了许多研究，现就相关研究的进展综述如下。
Kasasaki disease (KD) is an acute, self-limiting systemic vascular syndrome that mainly occurs in infants and children under the age of five years, and has become the leading cause of the acquired heart disease in children, which the most serious complication is coronary artery disease, that can lead to coronary dilaton, myocardial infarction and death. So early diagnosis is critically important, which can effectively reducing the incidence of coronary artery disease. In recent years, many studies have been conducted on biomakers for the early diagnosis of KD. The article reviews the progress of the related studies.
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