Nephroblastoma is
the most common malignant renal tumor in children and is related to an abnormal
proliferation of cells resembling those of the embryonic kidney (metanephroma),
hence the terminology; embryonal tumor. These are tumors that remain and remain
unstudied in Mali because they are common in adults in our context. Its annual
incidence is estimated at approximately 1/10,000 births. Nephroblastoma is a
rare or even exceptional tumor in adults. The clinical manifestation was
a large swelling of the right hypochondrium; abdominal pain for a year;
unquantified fever, hypertension, initial hematuria associated with burning
during urination and anemia. The main clinical manifestation remained fever and
abdominal pain. This renal tumor posed a diagnostic problem which was
previously labeled as a mesenteric tumor in our general surgery department. The
diagnosis was made by imaging: CT and magnetic resonance imaging. The treatment
is multidisciplinary and combines chemotherapy, surgery with or without
radiotherapy. The prognosis is poor due to late diagnosis and less
effectiveness of chemotherapy compared to the child. Survival did not exceed a
year and a half because the renal tumor in our patient was surgically overcome.
We report a case of nephroblastoma in an 86-year-old patient with unfavorable
histology (hematogenous metastases), operated on in the general surgery
department and whose postoperative course was simple and who was referred to
oncology for treatment.
References
[1]
Doumbia, A.K., Togo, P., Traore, F., Dackono, A., Diarra, A., et al. (2021) Prise en charge du néphroblastome à Bamako: À propos de 18 cas. Cancer Control Francophone, 2021, 64-66.
[2]
Diakite, F., Balde, M.S., Agbo, P.D., Diallo, M.L., Bah, A.B., et al. (2019) Néphroblastome: Aspects épidémiologique et thérapeutique à l’hôpital Donka de 2007 à 2012. Revue Internationale des Sciences Médicales, 21, 50-53.
[3]
Haouas, N., Sahraoui, W. and Sridi, K. (2005) Néphroblastome de l’adulte. Progrès en Urologie, 15, 326-328.
[4]
Kisra, M., Guennoun, A. and Benhmammouch, M.N. (2016) Traitement chirurgical du néphroblastome botryoïde. Journal Marocain des Sciences Médicales, No. 4, 52-58.
[5]
Tengue, K., Kpatcha, T.M., Sonhaye, L., Amavi, A.K., Leloua, E., Botcho, G., Sikpa, K., et al. (2015) Le cancer du rein de l’adulte au TOGO: Fréquence, Diagnostic, Traitement et Evolution. Uro’Andro, 1, 177-182.
[6]
Ouattara, K., Daffe, S. and Tembelly, A. (1993) Les tumeurs du rein dans la pratique de l’urologue au Mali (A propos de 17 cas). Médecine d’Afrique Noire, 40, 253-256.
[7]
Tordjiman, I. (2009) Cancers et substances chimiques. Institut National du Cancer (Inca), Collection, 1-4.
[8]
Blois, N., Colomb, J.-B., Goullet, E., Biserte, J. and Mazeman, E. (1999) Un cas de néphroblastome métastasé chez l’adulte d’évolution favorable sous cisplatyl, étoposide. Progrès en Urologie, 9, 731-733.
[9]
Benjelloun, M., Debbah, A., Mezzour, H., El Kentaoui, H., Joual, A., et al. (2003) Le néphroblastome chez l’adulte. A propos d’un cas. African Journal of Urology, 9, 190-194.
[10]
Vincent-Tremblay, M., Pharm, D., Scherer, H., et al. (2016) Traitement d’une tumeur de Wilms réfractaire chez l’adulte. Pharmactuel, 49, 1-16.
[11]
Cisse, B.D.A. (2008) Etude des aspects épidémio-cliniques du néphroblastome dans le service de pédiatrie du CHU Gabriel TOURE. Thèse de Médecine, Bamako.
[12]
Kadri, M.N. (2021): Prise en charge du néphroblastome au service d’HOP de Marrakech. Ph.D. Thesis, 115-121.
[13]
Diezi, M., Tercier, S., Osterheld, M.C. and Joseph, J.M. (2007) Tumeurs rénales de l’enfant. Revue Médicale Suisse, 3, 360-365.
[14]
Dainese, L. (2016) Caractérisation morphologique du néphroblastome, du blastème et de la région chromosomique 11p15 en particulier. Ph.D. Thesis.
[15]
Berthe, F. (2019) Etude rétrospective des cas de néphroblastome dans le service de pédiatrie à l’hôpital de SIKASSO. Thèse de Médecine, Bamako.