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不同治疗方式对恶性小肠梗阻患者的短期获益的影响
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Abstract:
目的:探讨不同治疗方式对恶性小肠梗阻患者的短期获益。方法:我们回顾性收集了2020年1月1日至2022年12月31日在青岛大学附属医院住院治疗的恶性小肠梗阻患者(非手术治疗患者36例,手术治疗患者73例)的临床数据(基本资料 + 血检结果 + 影像学特征),使用SPSS27.0进行统计学分析,并绘制Kaplan-Meier生存曲线。结果:手术治疗组在流质饮食率、症状缓解率方面,住院时间优于非手术治疗组;手术治疗组住院花费高于非手术治疗组;造口组患者腹腔内径纵横比大于非造口组患者;造口组患者肠壁水肿率、腹水出现率、大网膜区域肿瘤沉积率高于非造口组;造口组患者术后流质饮食恢复时间小于非造口组患者。手术治疗组总体生存时间优于非手术治疗组,造口与非造口手术方式对总体生存并无明显差异。结论:手术治疗能够使恶性小肠梗阻患者短期获益,并延长生存时间。
Purpose: This study aims to evaluate the short-term benefits of different treatment modalities for patients with Malignant Small Bowel Obstruction (MSBO). Methods: Clinical data, including basic information, blood test results, and imaging features, were retrospectively collected from patients with MSBO who were hospitalized at the Affiliated Hospital of Qingdao University from January 1, 2020, to December 31, 2022. The patients were divided into two groups: a non-operative treatment group (36 patients) and a surgical treatment group (73 patients). Statistical analysis was performed using SPSS 27.0, and Kaplan-Meier survival curves were plotted. Results: The surgical treatment group showed better outcomes in terms of hospital stay, fluid diet tolerance, and symptom relief rates compared to the non-operative treatment group. However, the cost of hospitalization was higher in the surgical treatment group. Furthermore, patients in the stoma group had a higher aspect ratio of the abdominal internal diameter compared to those in the non-stoma group. The stoma group also exhibited a higher rate of intestinal wall edema, ascites appearance, and tumor deposition in the greater omentum region. However, there was no significant difference in overall survival between the stoma and non-stoma surgical methods. Conclusions: Surgical treatment for patients with malignant small bowel obstruction can provide short-term benefits, such as improved hospital stay and symptom relief, and may prolong overall survival.
[1] | Ripamonti, C. and Bruera, E. (2002) Palliative Management of Malignant Bowel Obstruction. International Journal of Gynecological Cancer, 12, 135-143. https://doi.org/10.1046/j.1525-1438.2002.01103.x |
[2] | Cousins, S.E., Tempest, E. and Feuer, D.J. (2016) Surgery for the Resolution of Symptoms in Malignant Bowel Obstruction in Ad-vanced Gynaecological and Gastrointestinal Cancer. The Cochrane Database of Systematic Reviews, 2016, CD002764. https://doi.org/10.1002/14651858.CD002764.pub2 |
[3] | Demarest, K., Lavu, H., Collins, E. and Batra, V. (2023) Comprehensive Diagnosis and Management of Malignant Bowel Obstruction: A Review. Journal of Pain & Palliative Care Pharmacotherapy, 37, 91-105.
https://doi.org/10.1080/15360288.2022.2106012 |
[4] | Davis, M., Hui, D., Davies, A., et al. (2021) Medical Man-agement of Malignant Bowel Obstruction in Patients with Advanced Cancer: 2021 MASCC Guideline Update. Sup-portive Care in Cancer, 29, 8089-8096.
https://doi.org/10.1007/s00520-021-06438-9 |
[5] | Huang, X., Xue, J., Gao, M., et al. (2021) Medical Management of Inoperable Malignant Bowel Obstruction. The Annals of Pharmacotherapy, 55, 1134-1145. https://doi.org/10.1177/1060028020979773 |
[6] | 陈鹏举, 王林, 陈楠, 等. 手术治疗结直肠癌腹腔转移导致的恶性肠梗阻短期效果和预后分析[J]. 中华胃肠外科杂志, 2019, 22(11): 1051-1057. |
[7] | Shariff, F., Bogach, J., Guidolin, K., et al. (2022) Malignant Bowel Obstruction Management Over Time: Are We Doing Anything New? A Current Narrative Review. Annals of Surgical Oncology, 29, 1995-2005.
https://doi.org/10.1245/s10434-021-10922-1 |
[8] | Alese, O.B., Kim, S., Chen, Z., et al. (2015) Management Pat-terns and Predictors of Mortality among US Patients with Cancer Hospitalized for Malignant Bowel Obstruction. Cancer, 121, 1772-1778. https://doi.org/10.1002/cncr.29297 |
[9] | Aabo, K., Pedersen, H., Bach, F., et al. (1984) Surgical Management of Intestinal Obstruction in the Late Course of Malignant Disease. Acta Chirurgica Scandinavica, 150, 173-176 |
[10] | Bozzetti, F. (2019) The Role of Parenteral Nutrition in Patients with Malignant Bowel Obstruction. Supportive Care in Cancer, 27, 4393-4399. https://doi.org/10.1007/s00520-019-04948-1 |
[11] | Read, M., Powers, B.D., Pimiento, J.M., et al. (2022) Management of Malignant Small Bowel Obstruction: Is Intestinal Bypass Effective Palliation? Annals of Surgical Oncology, 29, 6980-6987.
https://doi.org/10.1245/s10434-022-12204-w |
[12] | Akba?, A., Daldal, E., Da??ran, F., et al. (2020) Does A Selec-tive Surgical Approach to Malignant Bowel Obstruction Help in Palliative Care Patients? Turkish Journal of Trauma & Emergency Surgery, 26, 875-882. |
[13] | Berger, J., Lester, P. and Rodrigues, L. (2016) Medical Therapy of Malignant Bowel Obstruction with Octreotide, Dexamethasone, and Metoclopramide. The American Journal of Hospice & Palli-ative Care, 33, 407-410.
https://doi.org/10.1177/1049909115569047 |
[14] | Ripamonti, C., Twycross, R., Baines, M., et al. (2001) Clini-cal-Practice Recommendations for the Management of Bowel Obstruction in Patients with End-Stage Cancer. Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer, 9, 223-233. https://doi.org/10.1007/s005200000198 |
[15] | Song, Y., Metzger, D.A., Bruce, A.N., et al. (2022) Surgical Out-comes in Patients with Malignant Small Bowel Obstruction: A National Cohort Study. Annals of Surgery, 275, e198-e205.
https://doi.org/10.1097/SLA.0000000000003890 |
[16] | Imai, K., Yasuda, H., Koda, K., et al. (2010) [An Analysis of Palliative Surgery for the Patients with Malignant Bowel Obstruction]. Gan to Kagaku Ryoho Cancer & Chemo-therapy, 37, 264-267. |
[17] | Medina-Franco, H., García-Alvarez, M.N., Ortiz-López, L.J., et al. (2008) Predictors of Adverse Surgical Outcome in the Management of Malignant Bowel Obstruction. Revista De Investigacion Clinica, 60, 212-216 |
[18] | Bouveresse, S., Piton, G., Badet, N., et al. (2019) Abdominal Compartment Syndrome and In-tra-Abdominal Hypertension in Critically Ill Patients: Diagnostic Value of Computed Tomography. European Radiology, 29, 3839-3846.
https://doi.org/10.1007/s00330-018-5994-x |
[19] | Wu, J., Lu, A.D., Zhang, L.P., et al. (2019) [Study of Clinical Outcome and Prognosis in Pediatric Core Binding Factor-Acute Myeloid Leukemia]. Chinese Journal of Hematology, 40, 52-57. |
[20] | Miccò, M., Sbarra, M., Gui, B., et al. (2020) Prognostic CT Findings of Malignant Bowel Obstruction in Patients with Advanced Ovarian Cancer. Tumori Journal, 106, 149-154. https://doi.org/10.1177/0300891619886657 |
[21] | Mukherjee, A. (2022) Isolation of Primary Normal and Can-cer-Associated Adipocytes from the Omentum. Methods in Molecular Biology, 2424, 167-175. https://doi.org/10.1007/978-1-0716-1956-8_11 |
[22] | Chen, P.J., Wang, L., Peng, Y.F., et al. (2020) Surgical In-tervention for Malignant Bowel Obstruction Caused By Gastrointestinal Malignancies. World Journal of Gastrointestinal Oncology, 12, 323-331.
https://doi.org/10.4251/wjgo.v12.i3.323 |
[23] | Cato, L.D., Evans, T. and Ward, S.T. (2021) A Single-Centre Ten-Year Retrospective Cohort Study of Malignant Small Bowel Obstruction. Annals of the Royal College of Surgeons of England, 103, 738-744.
https://doi.org/10.1308/rcsann.2021.0044 |
[24] | Krouse, R.S., Anderson, G.L., Arnold, K.B., et al. (2023) Surgical versus Non-Surgical Management for Patients with Malignant Bowel Obstruction (S1316): A Pragmatic Comparative Effectiveness Trial. The Lancet Gastroenterology & Hepatology, 8, 908-918. https://doi.org/10.1016/S2468-1253(23)00191-7 |
[25] | Bateni, S.B., Gingrich, A.A., Kirane, A.R., et al. (2021) Chemotherapy after Diagnosis of Malignant Bowel Obstruction Is Associated with Superior Survival for Medicare Pa-tients with Advanced Malignancy. Annals of Surgical Oncology, 28, 7555-7563. https://doi.org/10.1245/s10434-021-09831-0 |
[26] | Tigert, M., Lau, C., Mackay, H., et al. (2021) Factors Impacting Length of Stay and Survival in Patients with Advanced Gynecologic Malignancies and Malignant Bowel Obstruction. International Journal of Gynecological Cancer, 31, 727-732. https://doi.org/10.1136/ijgc-2020-002133 |
[27] | Razak, O.A., Yang, S.Y., Cho, M.S., et al. (2023) Palliative Surgery as a Bridge to Systemic Treatment for Malignant Bowel Obstruction Due to Peritoneal Metastases: A Retrospective, Case-Control Study. Asian Journal of Surgery, 46, 160-165. https://doi.org/10.1016/j.asjsur.2022.02.028 |
[28] | Kawabata, R., Fujitani, K., Sakamaki, K., et al. (2022) Survival Analysis of a Prospective Multicenter Observational Study on Surgical Palliation among Patients with Malignant Bowel Obstruction Caused by Peritoneal Dissemination of Gastric Cancer. Gastric Cancer, 25, 422-429. https://doi.org/10.1007/s10120-021-01251-z |
[29] | Kim, J., Yoon, C.J. and Seong, N.J. (2018) Transjejunostomy Stent Placement in Patients with Malignant Small-Bowel Obstructions. AJR American Journal of Roentgenology, 211, 1148-1154. https://doi.org/10.2214/AJR.18.19599 |