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唑来膦酸在骨性关节炎治疗中的研究进展
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Abstract:
OA (Osteoarthritis, OA)是临床上常见的一种逐渐进展的慢性退行性疾病，易导致关节疼痛、活动受限等，病程相对较长，且进展缓慢，临床无法治愈。随着OA病情的逐渐进展，关节破坏程度加重、活动受限导致肌肉萎缩，最后关节变形，严重影响日常生活。唑来膦酸是一种二膦酸盐，具有缓解疼痛、抑制骨重吸收的作用，常用于治疗骨质疏松、膝OA、变形性骨炎、高钙血症等疾病，疗效显著。基于此，本研究对唑来膦酸在OA治疗中的研究进展进行综述。
Osteoarthritis (OA) is a clinically common chronic autoimmune disease that progresses gradually. OA is not an autoimmune disease, but a degenerative disease, which can easily lead to joint pain, limited movement, etc., with a relatively long course of disease and slow progress, and cannot be cured clinically. With the gradual progress of OA, the degree of joint damage is aggravated, and the movement is limited, leading to muscle atrophy, and finally joint deformation, which seriously af-fects daily life. Zoledronic acid is a diphosphonate, which has the effect of relieving pain and inhib-iting bone resorption. It is often used in the treatment of osteoporosis, knee OA, osteitis deforming, hypercalcemia and other diseases, and the effect is significant. Based on this, this study reviews the research progress of zoledronic acid in the treatment of OA.
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