Introduction:
Quality of life in Parkinson disease is not necessary linked to motor symptoms.
It’s correlated of overactive bladders and prostatic symptoms. Prognosis
factors of urinary quality of life are unknown. Objectives: Our study aims to
find prognosis factors of quality of life associated specifically of urinary
disorders in PD. Patients and methods: We conducted a transversal, analytic and
descriptive study in Physical Medicine, and Neurology departments, Fann
Teaching Hospital, Dakar and included patients followed for treatment of PD.
Urinary disorders, quality of life and functional autonomy were assessed
respectively by Urinary Symptoms Profile (USP), Qualiven Short Form, Schwab and
England Scale. Results: 38 patients presented PD, with a mean age of 60.89 ±
13.6 years and sex-ratio of 2.45. Mean duration of PD was 3.1 ± 2.9 years.
Urinary disorders were found in 47.36% and dominated by incontinence (88.88%)
and overactive bladders (88.88%) which were minor in more than 55%. Quality of
life was impaired in 88.88% of cases. Minor forms (43.75%) were predominant and
constraint dimension (50%) was the most severely altered. Prognosis factors for
quality of life of urinary disorders were PD stages (0.046) and functional
autonomy (0.042). Discussion and conclusion: Urinary disorders in PD are
common, impaired quality of life, especially the constraint dimension, depends
on stage of evolution of PD and functional autonomy of patients.
References
[1]
Bonnet, A.M., Pichon, J., Vidailhet, M., Gouider-Khouja, N., Robain, G., Perrigot, M., et al. (1997) Urinary Disturbances in Striatonigral Degeneration and Parkinson’s Disease: Clinical and Urodynamic Aspects. Movement Disorders, 12, 509-513.
https://doi.org/10.1002/mds.870120406
[2]
Lewin, R.J., Dillard, G.V. and Porter, R.W. (1967) Extrapyramidal Inhibition of the Urinary Bladder. Brain Research, 4, 301-307.
https://doi.org/10.1016/0006-8993(67)90160-6
[3]
Sakakibara, R. (2001) Videourodynamic and Sphincter Motor Unit Potential Analyses in Parkinson’s Disease and Multiple System Atrophy. Journal of Neurology, Neurosurgery & Psychiatry, 71, 600-606. https://doi.org/10.1136/jnnp.71.5.600
[4]
Soler, J.M. and Le Portz, B. (2004) Les troubles vésicosphinctériens de la maladie de Parkinson. Annales d'Urologie, 38, S57-S61.
https://doi.org/10.1016/S0003-4401(04)80009-3
[5]
Evans, C. (1998) Neurological Disorders in the Ageing Population and Their Urological Implications. British Journal of Urology, 82, 71-78.
https://doi.org/10.1046/j.1464-410X.1998.0820s1071.x
[6]
Chen, Z., Li, G. and Liu, J. (2020) Autonomic Dysfunction in Parkinson’s Disease: Implications for Pathophysiology, Diagnosis, and Treatment. Neurobiology of Disease, 134, Article ID: 104700. https://doi.org/10.1016/j.nbd.2019.104700
[7]
Yamamoto, T., Uchiyama, T., Asahina, M., Yamanaka, Y., Hirano, S., Higuchi, Y. and Kuwabara, S. (2018) Urinary Symptoms Are Correlated with Quality of Life after Deep Brain Stimulation in Parkinson’s Disease. Brain and Behavior, 8, e01164.
https://doi.org/10.1002/brb3.1164
[8]
Wright Willis, A., Evanoff, B.A., Lian, M., Criswell, S.R. and Racette, B.A. (2010) Geographic and Ethnic Variation in Parkinson Disease: A Population-Based Study of US Medicare Beneficiaries. Neuroepidemiology, 34, 143-151.
https://doi.org/10.1159/000275491
[9]
Linder, J., Stenlund, H. and Forsgren, L. (2010) Incidence of Parkinson’s Disease and Parkinsonism in Northern Sweden: A Population-Based Study. Movement Disorders, 25, 341-348. https://doi.org/10.1002/mds.22987
[10]
Gillies, G.E., Pienaar, I.S., Vohra, S. and Qamhawi, Z. (2014) Sex Differences in Parkinson’s Disease. Frontiers in Neuroendocrinology, 35, 370-384.
https://doi.org/10.1016/j.yfrne.2014.02.002
[11]
Gouider-Khouja, N., Belal, S., Hamida, M.B. and Hentati, F. (2000) Clinical and Genetic Study of Familial Parkinson’s Disease in Tunisia. Neurology, 54, 1603-1609.
https://doi.org/10.1212/WNL.54.8.1603
[12]
Stocchi, F., Carbone, A., Inghilleri, M., Monge, A., Ruggieri, S., Berardelli, A., et al. (1997) Urodynamic and Neurophysiological Evaluation in Parkinson’s Disease and Multiple System Atrophy. Journal of Neurology, Neurosurgery & Psychiatry, 62, 507-511. https://doi.org/10.1136/jnnp.62.5.507
[13]
Siroky, M.B. (2003) Neurological Disorders Cerebrovascular Disease and Parkinsonism. Urologic Clinics of North America, 30, 27-47.
https://doi.org/10.1016/S0094-0143(02)00114-3
[14]
Araki, I., Kitahara, M., Oida, T. and Kuno, S. (2000) Voiding Dysfunction and Parkinson’s Disease: Urodynamic Abnormalities and Urinary Symptoms. The Journal of Urology, 164, 1640-1643. https://doi.org/10.1016/S0022-5347(05)67048-6
[15]
Schapira, A.H.V., Chaudhuri, K.R. and Jenner, P. (2017) Non-Motor Features of Parkinson Disease. Nature Reviews Neuroscience, 18, 509.
https://doi.org/10.1038/nrn.2017.91
[16]
Karlsen, K.H., Larsen, J.P., Tandberg, E. and Maeland, J.G. (1999) Influence of Clinical and Demographic Variables on Quality of Life in Patients with Parkinson’s Disease. Journal of Neurology, Neurosurgery & Psychiatry, 66, 431-435.
https://doi.org/10.1136/jnnp.66.4.431
[17]
Emna, T., Bayrem, H., Attia, R., Riahi, S., Boukhchina, R., Bouguila, H., et al. (2021) Troubles vésico-sphinctériens, troubles sexuels et qualité de vie chez les parkinsoniens: à propos d’une cohorte hospitalière tunisienne. Revue Neurologique, 177, S24. https://doi.org/10.1016/j.neurol.2021.02.132