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基于生物信息学分析筛选与鉴定宫颈癌的预后生物标志物
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Abstract:
宫颈癌发病率是女性排名第四的恶性肿瘤，宫颈癌死亡率也是女性恶性肿瘤的第四大恶性疾病。此外，近几十年来，年轻女性患宫颈癌的发病率有所增加。目前，有一些生物标志物(如鳞状细胞癌抗原(SCC-Ag))用于宫颈癌的诊断和预后。但是这些生物标志物缺乏敏感性和特异性，限制了它们的效用。因此，利用生物信息学更好地了解HPV (+)的非肿瘤宫颈组织和HPV (+)的宫颈癌肿瘤组织中差异基因表达及筛选关键诊断和预后基因，为寻找宫颈癌的新机制、更多预后因素和潜在治疗靶点提供进一步的研究思路。
The incidence of cervical cancer is the fourth most malignant disease in women, and the mortality rate of cervical cancer is also the fourth most malignant disease in women. In addition, the inci-dence of cervical cancer in young women has increased in recent decades. Currently, there are some biomarkers (such as squamous cell carcinoma antigen (SCC-Ag)) used for the diagnosis and progno-sis of cervical cancer. However, the lack of sensitivity and specificity of these biomarkers limits their utility. Therefore, using bioinformatics to better understand the differential gene expression in HPV (+) non-tumor cervical tissues and HPV (+) cervical cancer tissues and screen key diagnostic and prognostic genes provides further research ideas for finding new mechanisms of cervical cancer, more prognostic factors and potential therapeutic targets.
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