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肠道菌群及其代谢物在放射性肠炎中的研究进展
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Abstract:
放射性肠炎是盆腔放疗后的一种常见并发症，严重影响患者的生活质量。近年来，众多研究已经证实肠道菌群失调在放射性肠炎发生发展中起着重要作用。通过调节肠道菌群来治疗放射性肠炎的研究也较多，如补充益生元或益生菌、使用抗生素减少病原菌、肠道菌群移植等。此外，研究还发现，菌群代谢物作为菌群与宿主的纽带影响着放射性肠炎的发生发展，这些代谢物包括短链脂肪酸、胆汁酸以及色氨酸代谢物等。下面将以肠道菌群及其代谢物在放射性肠炎中的研究进展进行综述。
Radiation enteritis is a common complication after pelvic radiotherapy, which seriously affects the quality of life of patients. In recent years, many studies have confirmed that intestinal flora imbal-ance plays an essential role in the occurrence and development of radiation enteritis. There are also many studies on treating radiation enteritis by regulating intestinal flora, such as supplementing prebiotics or probiotics, using antibiotics to reduce pathogens, and transplanting intestinal flora. In addition, the study also found that bacterial community metabolites, including short-chain fatty ac-ids, bile acids, and tryptophan metabolites, as a link between the bacterial community and the host, affect the occurrence and development of radiation enteritis. The research progress of intestinal flora and their metabolites in radiation enteritis will be reviewed below.
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