|
|
富血小板血浆在肩袖撕裂修复中应用的现状与进展
|
Abstract:
肩袖主要控制肩关节的活动并维持稳定性，一旦损伤难以自愈。虽然关节镜术后肩袖结构和生物力学得到了提高，但目前研究的重点已经转向通过生物制剂来提高愈合质量。富血小板血浆(Platelet-Rich Plasma, PRP)作为一种新兴潜在的生物增强剂在促进肌腱骨愈合方面获得了良好的效果，近年来在肩袖损伤领域获得了很多人的关注，尽管多项研究表明PRP注射可以很好地控制疼痛，由于其类型多样、给药方式及次数等不同，且患者肩袖撕裂的类型及大小也存在差异，因此出现了不同的临床结果。本文旨在评估PRP在治疗肩袖损伤中的疗效和用途。
The rotator cuff mainly controls the movement of the shoulder joint and maintains stability, once the injury is difficult to heal itself. Although the rotator cuff structure and biomechanics have been improved after surgery, the focus of current research has shifted to improving the quality of healing through biologics. Platelet-Rich Plasma (PRP) has gained a lot of attention in the field of rotator cuff injuries in recent years as an emerging potential bioenhancer that promotes healing of tendons and bones, although multiple studies have shown that PRP injections provide good pain control. Due to the variety of its types, dosing methods and frequency, and the type and size of rotator cuff tears in patients, different clinical results have appeared. The purpose of this study was to evaluate the effi-cacy and usefulness of PRP in the treatment of rotator cuff injuries.
| [1] | Safran, O., Schroeder, J., Bloom, R., et al. (2011) Natural History of Nonoperatively Treated Symptomatic Rotator Cuff Tears in Patients 60 Years Old or Younger. The American Journal of Sports Medicine, 39, 710-714.
https://doi.org/10.1177/0363546510393944 |
| [2] | Rossi, L.A., Chahla, J., Verma, N.N., et al. (2020) Rotator Cuff Retears. JBJS Reviews, 8, e0039.
https://doi.org/10.2106/JBJS.RVW.19.00039 |
| [3] | Prodromos, C.C., Finkle, S., Prodromos, A., et al. (2021) Treatment of Rotator Cuff Tears with Platelet Rich Plasma: A Prospective study with 2 Year Follow-Up. BMC Musculo-skeletal Disorders, 22, Article No. 499.
https://doi.org/10.1186/s12891-021-04288-4 |
| [4] | Velasquez Garcia, A., Ingala Martini, L., Franco Abache, A. and Abdo, G. (2023) Role of Platelet-Rich Plasma in the Treatment of Rotator Cuff Tendinopathy. World Journal of Ortho-pedics, 14, 505-515.
https://doi.org/10.5312/wjo.v14.i7.505 |
| [5] | Rothrauff, B.B. and Tuan, R.S. (2014) Cellular Therapy in Bone-Tendon Interface Regeneration. Organogenesis, 10, 13-28. https://doi.org/10.4161/org.27404 |
| [6] | Hoppe, S., Alini, M., Benneker, L.M., et al. (2013) Tenocytes of Chronic Rotator Cuff Tendon Tears Can Be Stimulated by Plate-let-Released Growth Factors. Journal of Shoulder and Elbow Surgery, 22, 340-349.
https://doi.org/10.1016/j.jse.2012.01.016 |
| [7] | Gulotta, L.V. and Rodeo, S.A. (2009) Growth Factors for Rotator Cuff Repair. Clinics in Sports Medicine, 28, 13-23.
https://doi.org/10.1016/j.csm.2008.09.002 |
| [8] | Kobayashi, M., Itoi, E., Minagawa, H., et al. (2006) Expression of Growth Factors in the Early Phase of Supraspinatus Tendon Healing in Rabbits. Journal of Shoulder and Elbow Surgery, 15, 371-377.
https://doi.org/10.1016/j.jse.2005.09.003 |
| [9] | 白晓松, 高丽颖, 张顶顶, 等. 贫白细胞富血小板血浆注射修补肩袖全层撕裂: 低、高浓度组的比较[J]. 中国组织工程研究, 2023, 27(16): 2467-2472. |
| [10] | Voleti, P.B., Buckley, M.R. and Soslowsky, L.J. (2012) Tendon Healing: Repair and Regeneration. Annual Review of Biomedical Engineering, 14, 47-71. https://doi.org/10.1146/annurev-bioeng-071811-150122 |
| [11] | Kashiwagi, K., Mochizuki, Y., Yasunaga, Y., et al. (2004) Effects of Transforming Growth Factor-β 1 on the Early Stages of Healing of the Achilles Tendon in a Rat Model. Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery, 38, 193-197. https://doi.org/10.1080/02844310410029110 |
| [12] | Nielsen, R.H., Holm, L., Malmgaard-Clausen, N.M., et al. (2014) Increase in Tendon Protein Synthesis in Response to Insulin-Like Growth Factor-I Is Preserved in Elderly Men. Journal of Applied Physiology, 116, 42-46.
https://doi.org/10.1152/japplphysiol.01084.2013 |
| [13] | Thomopoulos, S., Zaegel, M., Das, R., et al. (2007) PDGF-BB Released in Tendon Repair Using a Novel Delivery System Promotes Cell Proliferation and Collagen Re-modeling. Journal of Orthopaedic Research, 25, 1358-1368.
https://doi.org/10.1002/jor.20444 |
| [14] | Chahal, J., Van Thiel, G.S., Mall, N., et al. (2012) The Role of Platelet-Rich Plasma in Arthroscopic Rotator Cuff Repair: A Systematic Review with Quantitative Synthesis. Arthroscopy, 28, 1718-1727.
https://doi.org/10.1016/j.arthro.2012.03.007 |
| [15] | Zhang, C., Cai, Y.Z. and Wang, Y. (2022) Injection of Leuko-cyte-Poor Platelet-Rich Plasma for Moderate-to-Large Rotator Cuff Tears Does Not Improve Clinical Outcomes but Re-duces Retear Rates and Fatty Infiltration: A Prospective, Single-Blinded Randomized Study. Arthroscopy, 38, 2381-2388.E1. https://doi.org/10.1016/j.arthro.2022.02.007 |
| [16] | Mall, N.A., Tanaka, M.J., Choi, L.S. and Paletta Jr., G.A. (2014) Factors Affecting Rotator Cuff Healing. The Journal of Bone & Joint Surgery, 96, 778-788. https://doi.org/10.2106/JBJS.M.00583 |
| [17] | Shams, A., El-Sayed, M., Gamal, O. and Ewes, W. (2016) Subacromi-al Injection of Autologous Platelet-Rich Plasma versus Corticosteroid for the Treatment of Symptomatic Partial Rotator Cuff Tears. European Journal of Orthopaedic Surgery & Traumatology, 26, 837-842. https://doi.org/10.1007/s00590-016-1826-3 |
| [18] | Randelli, P.S., Stoppani, C.A., Santarsiero, G., Nocerino, E. and Menon, A. (2022) Platelet-Rich Plasma in Arthroscopic Rotator Cuff Repair: Clinical and Radiological Results of a Pro-spective Randomized Controlled Trial Study at 10-Year Follow-Up. Arthroscopy, 38, 51-61. https://doi.org/10.1016/j.arthro.2021.05.017 |
| [19] | Cavendish, P.A., Everhart, J.S., DiBartola, A.C., et al. (2020) The Effect of Perioperative Platelet-Rich Plasma Injections on Postoperative Failure Rates following Rotator Cuff Repair: A Systematic Review with Meta-Analysis. Journal of Shoulder and Elbow Surgery, 29, 1059-1070. https://doi.org/10.1016/j.jse.2020.01.084 |
| [20] | Gwinner, C. and Scheibel, M. (2020) Editorial Commentary: Plate-let-Rich Plasma in the Treatment of Rotator Cuff Tears-From Hero to Zero? Arthroscopy, 36, 658-659. https://doi.org/10.1016/j.arthro.2019.11.105 |
| [21] | 王云峰, 徐伟, 宋舸, 等. 关节镜下肩袖修补术联合富血小板血浆治疗肩袖撕裂损伤68例[J]. 中国中医骨伤科杂志, 2020, 28(3): 66-69. |
| [22] | Wang, C., Xu, M., Guo, W., et al. (2019) Clinical Efficacy and Safety of Platelet-Rich Plasma in Arthroscopic Full-Thickness Rotator Cuff Repair: A Me-ta-Analysis. PLOS ONE, 14, e0220392.
https://doi.org/10.1371/journal.pone.0220392 |
| [23] | Le, A.D.K., Enweze, L., DeBaun, M.R. and Dragoo, J.L. (2018) Current Clinical Recommendations for Use of Platelet-Rich Plasma. Current Reviews in Musculoskeletal Medicine, 11, 624-634.
https://doi.org/10.1007/s12178-018-9527-7 |
| [24] | Ebert, J.R., Wang, A., Smith, A., et al. (2017) A Midterm Evalua-tion of Postoperative Platelet-Rich Plasma Injections on Arthroscopic Supraspinatus Repair: A Randomized Controlled Trial. The American Journal of Sports Medicine, 45, 2965-2974. https://doi.org/10.1177/0363546517719048 |
| [25] | Wang, A., McCann, P., Colliver, J., et al. (2015) Do Postopera-tive Platelet-Rich Plasma Injections Accelerate Early Tendon Healing and Functional Recovery after Arthroscopic Su-praspinatus Repair? A Randomized Controlled Trial. The American Journal of Sports Medicine, 43, 1430-1437. https://doi.org/10.1177/0363546515572602 |
| [26] | D’Ambrosi, R., Palumbo, F., Paronzini, A., et al. (2016) Plate-let-Rich Plasma Supplementation in Arthroscopic Repair of Full-Thickness Rotator Cuff Tears: A Randomized Clinical Trial. Musculoskeletal Surgery, 100, 25-32.
https://doi.org/10.1007/s12306-016-0415-2 |
| [27] | Schneider, A., Burr, R., Garbis, N. and Salazar, D. (2018) Plate-let-Rich Plasma and the Shoulder: Clinical Indications and Outcomes. Current Reviews in Musculoskeletal Medicine, 11, 593-597. https://doi.org/10.1007/s12178-018-9517-9 |
| [28] | Rossi, L.A., Piuzzi, N., Giunta, D., et al. (2021) Sub-acromial Platelet-Rich Plasma Injections Decrease Pain and Improve Functional Outcomes in Patients with Refractory Rotator Cuff Tendinopathy. Arthroscopy, 37, 2745-2753.
https://doi.org/10.1016/j.arthro.2021.03.079 |
| [29] | Rossi, L.A., Piuzzi, N., Tanoira, I., et al. (2023) Subacromial Platelet-Rich Plasma Injections Produce Significantly Worse Improvement in Functional Outcomes in Patients with Par-tial Supraspinatus Tears Than in Patients with Isolated Tendinopathy. Arthroscopy, 39, 2000-2008. https://doi.org/10.1016/j.arthro.2023.03.019 |
| [30] | Dukan, R., Bommier, A., Rousseau, M.A. and Boyer, P. (2019) Arthroscopic Knotless Tape Bridging with Autologous Platelet-Rich Fibrin Gel Augmentation: Functional and Structural Results. The Physician and Sportsmedicine, 47, 455-462.
https://doi.org/10.1080/00913847.2019.1623994 |
| [31] | Jo, C.H., Kim, J.E., Yoon, K.S., et al. (2011) Does Plate-let-Rich Plasma Accelerate Recovery after Rotator Cuff Repair? A Prospective Cohort Study. The American Journal of Sports Medicine, 39, 2082-2090.
https://doi.org/10.1177/0363546511413454 |
| [32] | Jo, C.H., Shin, J.S., Lee, Y.G., et al. (2013) Platelet-Rich Plasma for Arthroscopic Repair of Large to Massive Rotator Cuff Tears: A Randomized, Single-Blind, Parallel-Group Trial. The American Journal of Sports Medicine, 41, 2240-2248.
https://doi.org/10.1177/0363546513497925 |
| [33] | Zumstein, M.A., Rumian, A., Lesbats, V., et al. (2014) Increased Vascularization during Early Healing after Biologic Augmentation in Repair of Chronic Rotator Cuff Tears Using Autol-ogous Leukocyte- and Platelet-Rich Fibrin (L-PRF): A Prospective Randomized Controlled Pilot Trial. Journal of Shoul-der and Elbow Surgery, 23, 3-12.
https://doi.org/10.1016/j.jse.2013.08.017 |
| [34] | Walsh, M.R., Nelson, B.J., Braman, J.P., et al. (2018) Platelet-Rich Plasma in Fibrin Matrix to Augment Rotator Cuff Repair: A Prospective, Single-Blinded, Randomized Study with 2-Year Follow-Up. Journal of Shoulder and Elbow Surgery, 27, 1553-1563. https://doi.org/10.1016/j.jse.2018.05.003 |
| [35] | Saito, M., Takahashi, K.A., Arai, Y., et al. (2009) Intraarticular Ad-ministration of Platelet-Rich Plasma with Biodegradable Gelatin Hydrogel Microspheres Prevents Osteoarthritis Progres-sion in the Rabbit Knee. Clinical and Experimental Rheumatology, 27, 201-207. |
| [36] | Li, M., Wang, K., Zhang, H.J., et al. (2021) Clinical Evaluations of Intraoperative Injection of Platelet-Rich Plasma in Arthroscopic Single-Row Rotator Cuff Repair at 2-Year Follow-Up. BioMed Research International, 2021, Article ID: 6675097. https://doi.org/10.1155/2021/6675097 |
| [37] | 张军, 满家政, 冯仕明, 等. 双排缝合技术联合富血小板血浆在肩袖损伤中的疗效[J]. 实用医学杂志, 2022, 38(16): 2051-2055. |
| [38] | Hurley, E.T., Lim Fat, D., Moran, C.J., et al. (2019) The Efficacy of Platelet-Rich Plasma and Platelet-Rich Fibrin in Arthroscopic Rotator Cuff Repair: A Me-ta-Analysis of Randomized Controlled Trials. The American Journal of Sports Medicine, 47, 753-761. https://doi.org/10.1177/0363546517751397 |
| [39] | Vavken, P., Sadoghi, P., Palmer, M., et al. (2015) Platelet-Rich Plasma Reduces Retear Rates after Arthroscopic Repair of Small- and Medium-Sized Rotator Cuff Tears But Is Not Cost-Effective. The American Journal of Sports Medicine, 43, 3071-3076. https://doi.org/10.1177/0363546515572777 |
| [40] | Holtby, R., Christakis, M., Maman, E., et al. (2016) Impact of Platelet-Rich Plasma on Arthroscopic Repair of Small- to Medium-Sized Rotator Cuff Tears: A Randomized Controlled Trial. Orthopaedic Journal of Sports Medicine, 4.
https://doi.org/10.1177/2325967116665595 |
| [41] | Zafarani, Z., Mirzaee, F., Guity, M., et al. (2017) Clinical Results of Platelet-Rich Plasma for Partial Thickness Rotator Cuff Tears: A Case Series. The Archives of Bone and Joint Surgery, 5, 328-331. |
| [42] | Malavolta, E.A., Gracitelli, M.E.C., Assun？？o, J.H., et al. (2018) Clinical and Structural Evaluations of Rotator Cuff Repair with and without Added Platelet-Rich Plasma at 5-Year Follow-Up: A Prospective Randomized Study. The American Journal of Sports Medicine, 46, 3134-3141. https://doi.org/10.1177/0363546518795895 |
| [43] | Moraes, V.Y., Lenza, M., Tamaoki, M.J., et al. (2013) Plate-let-Rich Therapies for Musculoskeletal Soft Tissue Injuries. Cochrane Database of Systematic Reviews, 12, CD010071. https://doi.org/10.1002/14651858.CD010071.pub2 |
| [44] | Yang, J., Sun, Y., Xu, P., et al. (2016) Can Patients Get Better Clinical Outcomes by Using PRP in Rotator Cuff Repair: A Meta-Analysis of Randomized Controlled Trials. The Journal of Sports Medicine and Physical Fitness, 56, 1359-1367. |
| [45] | Saltzman, B.M., Jain, A., Campbell, K.A., et al. (2016) Does the Use of Platelet-Rich Plasma at the Time of Surgery Improve Clinical Outcomes in Arthroscopic Rotator Cuff Repair When Compared with Control Cohorts? A Systematic Review of Meta-Analyses. Arthroscopy, 32, 906-918. https://doi.org/10.1016/j.arthro.2015.10.007 |
| [46] | Jo, C.H., Shin, J.S., Shin, W.H., et al. (2015) Platelet-Rich Plas-ma for Arthroscopic Repair of Medium to Large Rotator Cuff Tears: A Randomized Controlled Trial. The American Journal of Sports Medicine, 43, 2102-2110.
https://doi.org/10.1177/0363546515587081 |
| [47] | Pandey, V., Bandi, A., Madi, S., et al. (2016) Does Application of Moderately Concentrated Platelet-Rich Plasma Improve Clinical and Structural Outcome after Arthroscopic Repair of Medium-Sized to Large Rotator Cuff Tear? A Randomized Controlled Trial. Journal of Shoulder and Elbow Surgery, 25, 1312-1322.
https://doi.org/10.1016/j.jse.2016.01.036 |
| [48] | Liu, B., Jeong, H.J., Yeo, J.H. and Oh, J.H. (2021) Efficacy of In-traoperative Platelet-Rich Plasma Augmentation and Postoperative Platelet-Rich Plasma Booster Injection for Rotator Cuff Healing: A Randomized Controlled Clinical Trial. Orthopaedic Journal of Sports Medicine, 9. https://doi.org/10.1177/23259671211006100 |
| [49] | Güle？, A., Bakkalba？？, B.？., Cumbul, A., et al. (2017) Effects of Local Platelet-Rich Plasma Injection on the Rate of Orthodontic Tooth Movement in a Rat Model: A Histomorphometric Study. American Journal of Orthodontics and Dentofacial Orthopedics, 151, 92-104. https://doi.org/10.1016/j.ajodo.2016.05.016 |
| [50] | Audigé, L., Blum, R., Müller, A.M., et al. (2015) Complications following Arthroscopic Rotator Cuff Tear Repair: A Systematic Review of Terms and Definitions with Focus on Shoul-der Stiffness. Orthopaedic Journal of Sports Medicine, 3. https://doi.org/10.1177/2325967115587861 |
| [51] | Kwong, C.A., Woodmass, J.M., Gusnowski, E.M., et al. (2021) Platelet-Rich Plasma in Patients with Partial-Thickness Rotator Cuff Tears or Tendinopathy Leads to Significantly Improved Short-Term Pain Relief and Function Compared with Cor-ticosteroid Injection: A Double-Blind Randomized Controlled Trial. Arthroscopy, 37, 510-517.
https://doi.org/10.1016/j.arthro.2020.10.037 |
| [52] | Tanpowpong, T., Thepsoparn, M., Numkarunarunrote, N., et al. (2023) Effects of Platelet-Rich Plasma in Tear Size Reduction in Partial-Thickness Tear of the Supraspinatus Tendon Compared to Corticosteroids Injection. Sports Medicine—Open, 9, Article No. 11. https://doi.org/10.1186/s40798-023-00556-w |
| [53] | Chen, X., Jones, I.A., Park, C., et al. (2018) The Efficacy of Platelet-Rich Plasma on Tendon and Ligament Healing: A Systematic Review and Meta-Analysis with Bias Assessment. The American Journal of Sports Medicine, 46, 2020-2032.
https://doi.org/10.1177/0363546517743746 |
| [54] | Blaine, T., Moskowitz, R., Udell, J., et al. (2008) Treatment of Persistent Shoulder Pain with Sodium Hyaluronate: A Randomized, Controlled Trial. A Multicenter Study. The Journal of Bone & Joint Surgery, 90, 970-979.
https://doi.org/10.2106/JBJS.F.01116 |
| [55] | Honda, H., Gotoh, M., Kanazawa, T., et al. (2017) Hyaluronic Acid Accelerates Tendon-to-Bone Healing after Rotator Cuff Repair. The American Journal of Sports Medicine, 45, 3322-3330. https://doi.org/10.1177/0363546517720199 |
| [56] | Liu, W., Lin, B., Yao, H., et al. (2022) Effects of So-dium Hyaluronate in the Treatment of Rotator Cuff Lesions: A Systematic Review and Meta-Analysis. Orthopaedic Journal of Sports Medicine, 10.
https://doi.org/10.1177/23259671221115743 |
| [57] | Cai, Y.U., Sun, Z., Liao, B., et al. (2019) Sodium Hyaluronate and Platelet-Rich Plasma for Partial-Thickness Rotator Cuff Tears. Medicine & Science in Sports & Exercise, 51, 227-233. https://doi.org/10.1249/MSS.0000000000001781 |
