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基于内生邪气理论探讨银屑病发病与其组织病理学改变的关系
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Abstract:
内生邪气在中医古籍中常作“化气”论述，为病理状态下的阳气变动，化气之为病与现代医学领域中自身免疫性疾病的关系十分密切。银屑病作为一种由遗传与环境共同作用诱发的免疫介导的慢性、复发性、炎症性、系统性疾病，近年来有越来越多证据表明宜将本病归于自身免疫相关性疾病的范畴。据此，本文浅要梳理了古今内伤化气病的文献记载，阐述了其与自身免疫性疾病的关系。并从银屑病发病的免疫学机制入手，讨论了银屑病与中医化气病的关系，再结合本病不同时期皮损的皮肤组织病理学改变，围绕银屑病发病、病理变化及治疗转归等方面，作出外感邪气引动内伤化气的相关探讨，以期丰富中医化气学说，亦为银屑病的中医病因病机认识及治疗策略提供新见解。
Endogenous pathogen is often discussed as “hua qi” in materials of ancient Chinese medicine, which means the change of Yang qi in pathological state. The disease caused by hua qi is closely related to autoimmune diseases in modern medical field. Psoriasis is an immune-mediated chronic, recurrent, inflammatory and systemic disease induced by genetic and environmental interaction. In recent years, more and more evidence suggests that this disease should be classified as an autoimmune related disease. Based on this, this paper briefly combs the ancient and modern literature records of internal damage by hua qi and expounds its relationship with autoimmune diseases. And starting from the immunological mechanism of psoriasis, the relationship between psoriasis and hua qi dis-ease was discussed. Then, considering the histopathological changes of skin lesions in different pe-riods of psoriasis, this paper discusses the influence of endogenous pathogen caused by external pathogen from the aspects of pathogenesis, pathological changes and treatment outcomes. It is hoped that the above work can enrich the theory of hua qi in traditional Chinese medicine, and also provide new insights into the etiology and pathogenesis of psoriasis in traditional Chinese medicine and the treatment strategy.
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