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PI3K/Akt信号通路抑制剂在妇科恶性肿瘤治疗中的研究进展
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Abstract:
PI3K/Akt信号通路在细胞生长、增殖、迁移、代谢和分泌等各种细胞调控过程中起着至关重要的作用。PI3K/Akt信号转导是一种致癌途径，多项研究表明，PI3K/Akt信号转导的激活有利于增加肿瘤细胞的增殖和转移以及诱导治疗耐药性，这使得PI3K/Akt信号通路可成为肿瘤诊断及治疗的新靶点之一，因此，该通路的药物靶点有望成为癌症防治的有效临床治疗方法。PI3K/Akt信号通路抑制剂包括泛PI3K抑制剂(pan-PI3Ki)、亚型特异性PI3K抑制剂(IS PI3Ki)、双PI3K/mTOR抑制剂和Akt抑制剂。其中泛PI3K抑制剂是研究最多的药物。本文综述了PI3K/Akt信号通路抑制剂在疾病中的分子机制及其与妇科恶性肿瘤的关系，为妇科恶性肿瘤的治疗提供新的选择。
The PI3K/Akt signaling pathway plays a crucial role in various cellular regulatory processes such as cell growth, proliferation, migration, metabolism and secretion. PI3K/Akt signal transduction is a carcinogenic pathway. Multiple studies have shown that activation of PI3K/Akt signal transduction is conducive to increasing the proliferation and metastasis of tumor cells and inducing therapeutic resistance, which makes the PI3K/Akt signaling pathway a new target for tumor diagnosis and treatment. Therefore, drug targets of this pathway are expected to become effective clinical therapies for cancer prevention and treatment. PI3K/Akt signaling pathway inhibitors include pan-PI3K inhibitors (panPI3Ki), subtype-specific PI3K inhibitors (ISPI3Ki), dual PI3K/mTOR inhibitors and Akt inhibitors. PanPI3K inhibitors are the most studied of these drugs. This article reviews the molecular mechanism of PI3K/Akt signaling pathway inhibitors in diseases and their relationship with gynecologic malignancies, providing a new option for the treatment of gynecologic malignancies.
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