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山竹中α-倒捻子素的生物活性研究进展
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Abstract:
山竹(Garcinia mangostana L.)是一种具有营养和药用价值的热带水果，在传统医学中，其果皮常被用于治疗溃疡、炎症、疼痛、腹泻、痢疾和创伤等。山竹广泛的生物活性可能与山竹中的主要活性成分α-倒捻子素有关。α-倒捻子素是山竹果的主要成分，在山竹的多个部位均有分布，包括果壳，果实和树皮等，近年来受到广泛关注。然而，目前还缺乏对α-倒捻子素生物活性的全面总结，这不利于α-倒捻子素的开发。为进一步促进山竹的商业化，本文综述了近年来有关α-倒捻子素生物活性及其分子机制的研究报道，为α-倒捻子素的进一步开发利用提供理论依据。
The mangosteen (Garcinia mangostana L.) is a tropical fruit with nutritional and medicinal properties. In traditional medicine, its fruit peel is often used to treat ulcers, inflammation, pain, diarrhea, dysentery and trauma. The wide range of bioactivity of mangosteen may be related to α-mangostin, the main active ingredient in mangosteen. α-Mangostin is the main component of mangosteen, which exists in various parts of mangosteen, including the shell, fruit and bark, etc., and it has received extensive attention in recent years. However, there is a lack of comprehen-sive summary of the ioactivity of α-mangostin, which is not conducive to the development of α-mangostin. In order to further promote the commercialization of mangosteen, the recent reports on the ioactivity and molecular mechanism of α-mangostin were reviewed in this paper, which provided theoretical basis for the further development and utilization of α-mangostin.
| [1] | Sabahi, S., Homayouni Rad, A., Aghebati-Maleki, L., et al. (2022) Postbiotics as the New Frontier in Food and Pharmaceutical Research. Critical Reviews in Food Science and Nutrition, 63, 8375-8402. |
| [2] | Lai, W.F. and Wong, W.T. (2021) Design and Optimization of Quercetin-Based Functional Foods. Critical Reviews in Food Science and Nutrition, 62, 7319-7335. https://doi.org/10.1080/10408398.2021.1913569 |
| [3] | Yuvanatemiya, V., Srean, P., Klangbud, W.K., et al. (2022) A Review of the Influence of Various Extraction Techniques and the Biological Effects of the Xanthones from Mangosteen (Garcinia mangostana L.) Pericarps. Molecules, 27, Article No. 8775. https://doi.org/10.3390/molecules27248775 |
| [4] | Britt, K.L., Cuzick, J. and Phillips, K.A. (2020) Key Steps for Effective Breast Cancer Prevention. Nature Reviews Cancer, 20, 417-436. https://doi.org/10.1038/s41568-020-0266-x |
| [5] | Zhu, X., Li, J., Ning, H., et al. (2021) α-Mangostin Induces Apoptosis and Inhibits Metastasis of Breast Cancer Cells via Regulating RXRα-AKT Signaling Pathway. Frontiers in Pharmacology, 12, Article ID: 739658.
https://doi.org/10.3389/fphar.2021.739658 |
| [6] | Kurose, H., Shibata, M.A., Iinuma, M., et al. (2012) Altera-tions in Cell Cycle and Induction of Apoptotic Cell Death in Breast Cancer Cells Treated with α-Mangostin Extracted from Mangosteen Pericarp. Journal of Biomedicine and Biotechnology, 2012, Article ID: 672428. https://doi.org/10.1155/2012/672428 |
| [7] | Simon, S.E., Lim, H.S., Jayakumar, F.A., et al. (2022) α-Mangostin Activates MOAP-1 Tumor Suppressor and Mitochondrial Signaling in MCF-7 Human Breast Cancer Cells. Evi-dence-Based Complementary and Alternative Medicine, 2022, Article ID: 7548191. https://doi.org/10.1155/2022/7548191 |
| [8] | Yang, S., Zhou, F., Dong, Y., et al. (2021) α-Mangostin Induces Apoptosis in Human Osteosarcoma Cells through ROS-Mediated Endoplasmic Reticulum Stress via the WNT Pathway. Cell Transplantation, 30, 1-9.
https://doi.org/10.1177/09636897211035080 |
| [9] | Park, S.J., Park, B.S., Yu, S.B., et al. (2018) Induction of Apoptosis and Inhibition of Epithelial Mesenchymal Transition by α-Mangostin in MG-63 Cell Lines. Evi-dence-Based Complementary and Alternative Medicine, 2018, Article ID: 3985082. https://doi.org/10.1155/2018/3985082 |
| [10] | Zhang, H., Tan, Y.P., Zhao, L., et al. (2020) Anticancer Activity of Dietary Xanthone α-Mangostin against Hepatocellular Carcinoma by Inhibition of STAT3 Signaling via Stabilization of SHP1. Cell Death and Disease, 11, Article No. 63. https://doi.org/10.1038/s41419-020-2227-4 |
| [11] | Lee, H.N., Jang, H.Y., Kim, H.J., et al. (2016) Antitumor and Apoptosis-Inducing Effects of α-Mangostin Extracted from the Pericarp of the Mangosteen Fruit (Garcinia mangostana L.) in YD-15 Tongue Mucoepidermoid Carcinoma Cells. International Journal of Molecular Medicine, 37, 939-948. https://doi.org/10.3892/ijmm.2016.2517 |
| [12] | Chien, H.J., Ying, T.H., Hsieh, S.C., et al. (2020) α-Mangostin Attenuates Stemness and Enhances Cisplatin-Induced Cell Death in Cervical Cancer Stem-Like Cells through In-duction of Mitochondrial-Mediated Apoptosis. Journal of Cellular Physiology, 235, 5590-5601. https://doi.org/10.1002/jcp.29489 |
| [13] | Lee, C.H., Ying, T.H., Chiou, H.L., et al. (2017) α-Mangostin Induces Apoptosis through Activation of Reactive Oxygen Species and ASK1/p38 Signaling Pathway in Cervical Cancer Cells. Oncotarget, 8, 47425-47439.
https://doi.org/10.18632/oncotarget.17659 |
| [14] | Ma, Y., Yu, W., Shrivastava, A., et al. (2019) Inhibition of Pancreatic Cancer Stem Cell Characteristics by α-Mangostin: Molecular Mechanisms Involving Sonic Hedgehog and Nanog. Journal of Cellular and Molecular Medicine, 23, 2719-2730.
https://doi.org/10.1111/jcmm.14178 |
| [15] | Zhang, C., Yu, G. and Shen, Y. (2018) The Naturally Occurring Xanthone α-Mangostin Induces ROS-Mediated Cytotoxicity in Non-Small Scale Lung Cancer Cells. Saudi Journal of Biological Sciences, 25, 1090-1095.
https://doi.org/10.1016/j.sjbs.2017.03.005 |
| [16] | Phan, T.K.T., Shahbazzadeh, F. and Kihara, T. (2020) α-Mangostin Reduces Mechanical Stiffness of Various Cells. Human Cell, 33, 347-355. https://doi.org/10.1007/s13577-020-00330-0 |
| [17] | Eisvand, F., Imenshahidi, M., Ghasemzadeh Rahbardar, M., et al. (2022) Cardioprotective Effects of α-Mangostin on Doxorubicin-Induced Cardiotoxicity in Rats. Phytotherapy Research, 36, 506-524. https://doi.org/10.1002/ptr.7356 |
| [18] | You, B.H., Chae, H.S., Song, J., et al. (2017) α-Mangostin Ameliorates Dextran Sulfate Sodium-Induced Colitis through Inhibition of NF-kappaB and MAPK Pathways. International Immunopharmacology, 49, 212-221.
https://doi.org/10.1016/j.intimp.2017.05.040 |
| [19] | Hu, Y.H., Han, J., Wang, L., et al. (2021) α-Mangostin Al-leviated Inflammation in Rats with Adjuvant-Induced Arthritis by Disrupting Adipocytes-Mediated Metabo-lism-Immune Feedback. Frontiers in Pharmacology, 12, Article ID: 692806.
https://doi.org/10.3389/fphar.2021.692806 |
| [20] | Tao, M., Jiang, J., Wang, L., et al. (2018) α-Mangostin Alle-viated Lipopolysaccharide Induced Acute Lung Injury in Rats by Suppressing NAMPT/NAD Controlled Inflam-matory Reactions. Evidence-Based Complementary and Alternative Medicine, 2018, Article ID: 5470187. https://doi.org/10.1155/2018/5470187 |
| [21] | Kim, H.J., Park, S., Shin, H.Y., et al. (2021) Inhibitory Effects of α-Mangostin on T Cell Cytokine Secretion via ORAI1 Calcium Channel and K(+) Channels Inhibition. PeerJ, 9, e10973. https://doi.org/10.7717/peerj.10973 |
| [22] | Wang, M.-H., Zhang, K.-J., Gu, Q.-L., et al. (2017) Phar-macology of Mangostins and Their Derivatives: A Comprehensive Review. Chinese Journal of Natural Medicines, 15, 81-93. https://doi.org/10.1016/S1875-5364(17)30024-9 |
| [23] | Ye, H., Wang, Q., Zhu, F., et al. (2020) An-tifungal Activity of α-Mangostin against Colletotrichum gloeosporioides in Vitro and in Vivo. Molecules, 25, Article No. 5335. https://doi.org/10.3390/molecules25225335 |
| [24] | Leelapornpisid, W. (2022) Efficacy of α-Mangostin for Antimicrobial Activity against Endodontopathogenic Microorganisms in a Multi-Species Bacteri-al-Fungal Biofilm Model. Archives of Oral Biology, 133, Article ID: 105304.
https://doi.org/10.1016/j.archoralbio.2021.105304 |
| [25] | Sugiyanto, Z., Yohan, B., Hadisaputro, S., et al. (2019) Inhibitory Effect of α-Mangostin to Dengue Virus Replication and Cytokines Expression in Human Peripheral Blood Mononuclear Cells. Natural Products and Bioprospecting, 9, 345-349.
https://doi.org/10.1007/s13659-019-00218-z |
| [26] | Patil, P., Agrawal, M., Almelkar, S., et al. (2021) In Vitro and in Vivo Studies Reveal α-Mangostin, a Xanthonoid from Garcinia mangostana, as a Promising Natural Antiviral Compound against Chikungunya Virus. Virology Journal, 18, Article No. 47. https://doi.org/10.1186/s12985-021-01517-z |
| [27] | Yongpitakwattana, P., Morchang, A., Panya, A., et al. (2021) α-Mangostin Inhibits Dengue Virus Production and Pro- Inflammatory Cytokine/Chemokine Expression in Dendritic Cells. Archives of Virology, 166, 1623-1632.
https://doi.org/10.1007/s00705-021-05017-x |
| [28] | Chen, S.P., Lin, S.R., Chen, T.H., et al. (2021) Mangosteen Xanthone Gamma-Mangostin Exerts Lowering Blood Glucose Effect with Potentiating Insulin Sensitivity through the Mediation of AMPK/PPARgamma. Biomedicine & Pharmacotherapy, 144, Article ID: 112333. https://doi.org/10.1016/j.biopha.2021.112333 |
| [29] | Liu, T., Duan, W., Nizigiyimana, P., et al. (2018) α-Mangostin Attenuates Diabetic Nephropathy in Association with Suppression of Acid Sphingomyelianse and Endoplasmic Reticulum Stress. Biochemical and Biophysical Research Communications, 496, 394-400. https://doi.org/10.1016/j.bbrc.2018.01.040 |
| [30] | Rahmaniah, R., Yuyuntia, Y., Soetikno, V., et al. (2018) Al-pha Mangostin Inhibits Hepatic Stellate Cells Activation through TGF-beta/Smad and Akt Signaling Pathways: An in Vitro Study in LX2. Drug Research (Stuttg), 68, 153-158.
https://doi.org/10.1055/s-0043-119074 |
| [31] | Fu, T., Li, H., Zhao, Y., et al. (2018) Hepatoprotective Effect of α-Mangostin against Lipopolysaccharide/d-Galacto- samine-Induced Acute Liver Failure in Mice. Biomedicine & Pharmacotherapy, 106, 896-901.
https://doi.org/10.1016/j.biopha.2018.07.034 |
| [32] | Tatiya-Aphiradee, N., Chatuphonprasert, W. and Ja-rukamjorn, K. (2021) Ethanolic Garcinia mangostana Extract and α-Mangostin Improve Dextran Sulfate Sodi-um-Induced Ulcerative Colitis via the Suppression of Inflammatory and Oxidative Responses in ICR Mice. Journal of Ethnopharmacology, 265, Article ID: 113384.
https://doi.org/10.1016/j.jep.2020.113384 |
| [33] | Zhang, W., Jiang, G., Zhou, X., et al. (2022) α-Mangostin In-hibits LPS-Induced Bone Resorption by Restricting Osteoclastogenesis via NF-kappaB and MAPK Signaling. Chi-nese Medicine, 17, Article No. 34.
https://doi.org/10.1186/s13020-022-00589-5 |
| [34] | Li, J.X., Su, W.P., Pei, Y., et al. (2023) Ball Milling Extrac-tion as a Green and Efficient Approach for the Extraction of Sixteen Xanthone-Type QR-2 and PTP1B Inhibitors from Garcinia mangostana L. Pericarp. Food Analytical Methods, 16, 1069-1078. https://doi.org/10.1007/s12161-023-02495-4 |
| [35] | 汤卓雅, 潘月华, 张君生, 等. 山竹果皮中异戊烯基双苯吡酮类成分(英文) [J]. 中山大学学报(自然科学版), 2020, 59(6): 21-32. https://doi.org/10.13471/j.cnki.acta.snus.2020.02.27.2020c005 |
