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基于Web of Science的阿尔茨海默症伴抑郁症状的文献计量学分析
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Abstract:
目的：分析近5年阿尔茨海默症(Alzheimer’s disease)伴抑郁症状的研究现状和发展趋势，为国内外相关研究提供参考。方法：计算机检索Web of Science核心数据库，纳入2018~2022年发表的有关AD伴抑郁症状的英文文献，使用CiteSpace 6.1R6软件分别进行国家、机构、作者分析和关键词分析。结果：共纳入2655篇文献，美国的发文量最多，其次是中国；主要研究机构为高等院校；代表作者是HERRMANN，高频关键词有Alzheimer’s disease、dementia、depression、mild cognitive im-pairment等。该领域包含18个关键词聚类结果，演化路径可归纳为病理机制和影像学表现时期、危险因素和不良健康结局时期、干预治疗时期。结论：AD伴抑郁症状的研究热度逐年上升，机构、研究者之间可进一步加强合作，研究热点涉及AD伴抑郁症状的病理机制、危险因素、不良健康结局，AD伴抑郁症状的干预与治疗是未来的发展趋势。
Objective: To analyze the current research status and development trend of Alzheimer’s disease (AD) with depressive symptoms in the past 5 years, and to provide reference for domestic and in-ternational related research. Methods: A computerized search of the Web of Science core database was performed to include English-language literature on AD with depressive symptoms published from 2018 to 2022, and the data were processed using CiteSpace 6.1R6 software, with country, in-stitution, author analysis and keyword analysis performed separately. Results: A total of 2655 documents were included, The United States has the highest number of publications, followed by China; the main research institutions are institutions of higher learning; the representative author was HERRMANN, and the high-frequency keywords were Alzheimer’s disease, dementia, depres-sion, mild cognitive impairment, etc. The field contains 18 keyword clustering results, and the evo-lutionary path can be categorized into the period of pathological mechanisms and imaging mani-festations, the period of risk factors and adverse health outcomes, and the period of intervention and treatment. Conclusion: The research fever of AD with depressive symptoms is increasing year by year, and the cooperation between institutions and researchers can be further strengthened, and the research hotspots involve the pathological mechanisms, related risk factors, and adverse health outcomes of AD with depressive symptoms; the intervention and treatment of AD with de-pressive symptoms are the future development trend.
| [1] | Scheltens, P., De Strooper, B., Kivipelto, M., et al. (2021) Alzheimer’s Disease. The Lancet, 397, 1577-1590.
https://doi.org/10.1016/S0140-6736(20)32205-4 |
| [2] | Ren, R., Qi, J., Lin, S., et al. (2022) The China Alzheimer Report 2022. General Psychiatry, 35, e100751.
https://doi.org/10.1136/gpsych-2022-100751 |
| [3] | 杨芙蓉, 凌格, 朱潇旭, 等. 中医理论探析老年期痴呆与抑郁症的相关性[J]. 中华中医药杂志, 2021, 36(3): 1307-1310. |
| [4] | 邓泽南, 马秋平, 吴彬, 等. 阿尔茨海默病患者情绪障碍管理的最佳证据总结[J]. 中华护理杂志, 2021, 56(11): 1714-1720. |
| [5] | Kim, H., Jeong, W., Kwon, J., et al. (2021) Association between Depression and the Risk of Alzheimer’s Disease Using the Korean National Health In-surance Service-Elderly Cohort. Scientific Reports, 11, Article No. 22591.
https://doi.org/10.1038/s41598-021-02201-6 |
| [6] | 普赖斯, D., 张季娅. 洛特卡定律与普赖斯定律[J]. 科学学与科学技术管理, 1984(9): 17-22. |
| [7] | Chen, C. (2004) Searching for Intellectual Turning Points: Progressive Knowledge Domain Visualization. Proceedings of the National Academy of Sciences of the United States of America, 101, 5303-5310.
https://doi.org/10.1073/pnas.0307513100 |
| [8] | Mintzer, J., Lanct？t, K.L., Scherer, R.W., et al. (2021) Effect of Methylphenidate on Apathy in Patients with Alzheimer Disease: The ADMET 2 Randomized Clinical Trial. JAMA Neu-rology, 78, 1324-1332.
https://doi.org/10.1001/jamaneurol.2021.3356 |
| [9] | Harerimana, N.V., Liu, Y., Gerasimov, E.S., et al. (2022) Ge-netic Evidence Supporting a Causal Role of Depression in Alzheimer’s Disease. Biological Psychiatry, 92, 25-33. https://doi.org/10.1016/j.biopsych.2021.11.025 |
| [10] | Holmes, C., Arranz, M., Collier, D., et al. (2003) Depression in Alzheimer’s Disease: The Effect of Serotonin Receptor Gene Variation. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 119B, 40-43.
https://doi.org/10.1002/ajmg.b.10068 |
| [11] | Luca, M., Di Mauro, M., Di Mauro, M., et al. (2019) Gut Microbiota in Alzheimer’s Disease, Depression, and Type 2 Diabetes Mellitus: The Role of Oxidative Stress. Oxidative Medicine and Cellular Longevity, 2019, Article ID: 4730539. https://doi.org/10.1155/2019/4730539 |
| [12] | Lin, L., Zheng, L.J. and Zhang, L.J. (2018) Neuroinflammation, Gut Microbiome, and Alzheimer’s Disease. Molecular Neurobiology, 55, 8243-8250. https://doi.org/10.1007/s12035-018-0983-2 |
| [13] | Silva, M.V.F., Loures, C.M.G., Alves, L.C.V., et al. (2019) Alzheimer’s Disease: Risk Factors and Potentially Protective Measures. Journal of Biomedical Science, 26, Arti-cle No. 33. https://doi.org/10.1186/s12929-019-0524-y |
| [14] | Muntsant, A. and Giménez-Llort, L. (2022) Crosstalk of Alzheimer’s Disease-Phenotype, HPA Axis, Splenic Oxidative Stress and Frailty in Late-Stages of Dementia, with Special Concerns on the Effects of Social Isolation: A Translational Neuroscience Approach. Frontiers in Aging Neuro-science, 14, Article 969381.
https://doi.org/10.3389/fnagi.2022.969381 |
| [15] | Dolotov, O.V., Inozemtseva, L.S., Myasoedov, N.F., et al. (2022) Stress-Induced Depression and Alzheimer’s Disease: Focus on Astrocytes. International Journal of Molecular Sciences, 23, Article 4999.
https://doi.org/10.3390/ijms23094999 |
| [16] | Wenzler, S., et al. (2017) Integrated Biomarkers for Depression in Alz-heimer’s Disease: A Critical Review. Current Alzheimer Research, 14, 441-452. https://doi.org/10.2174/1567205013666160603011256 |
| [17] | Galts, C.P.C., Bettio, L.E.B., Jewett, D.C., et al. (2019) Depression in Neurodegenerative Diseases: Common Mechanisms and Current Treatment Options. Neuroscience and Biobehavioral Reviews, 102, 56-84.
https://doi.org/10.1016/j.neubiorev.2019.04.002 |
| [18] | Leszek, J., Mikhaylenko, E.V., Belousov, D.M., et al. (2021) The Links between Cardiovascular Diseases and Alzheimer’s Disease. Current Neuropharmacology, 19, 152-169. https://doi.org/10.2174/18756190MTA4dNjE52 |
| [19] | Kim, D., Wang, R., Kiss, A., et al. (2021) Depression and Increased Risk of Alzheimer’s Dementia: Longitudinal Analyses of Modifiable Risk and Sex-Related Factors. The American Journal of Geriatric Psychiatry, 29, 917-926.
https://doi.org/10.1016/j.jagp.2020.12.031 |
| [20] | Schliep, K.C., Barbeau, W.A., Lynch, K.E., et al. (2022) Overall and Sex-Specific Risk Factors for Subjective Cognitive Decline: Findings from the 2015-2018 Behavioral Risk Factor Surveillance System Survey. Biology of Sex Differences, 13, Article No. 16. https://doi.org/10.1186/s13293-022-00425-3 |
| [21] | Billioti de Gage, S., Moride, Y., Ducruet, T., et al. (2014) Ben-zodiazepine Use and Risk of Alzheimer’s Disease: Case-Control Study. BMJ, 349, g5205. https://doi.org/10.1136/bmj.g5205 |
| [22] | Jia, L., Du, Y., Chu, L., et al. (2020) Prevalence, Risk Factors, and Man-agement of Dementia and Mild Cognitive Impairment in Adults Aged 60 Years or Older in China: A Cross-Sectional Study. The Lancet Public Health, 5, e661-e671. https://doi.org/10.1016/S2468-2667(20)30185-7 |
| [23] | Morgese, M.G. and Trabace, L. (2019) Monoaminergic System Modulation in Depression and Alzheimer’s Disease: A New Standpoint? Frontiers in Pharmacology, 10, Article 483. https://doi.org/10.3389/fphar.2019.00483 |
| [24] | Yan, Z. and Rein, B. (2022) Mechanisms of Synaptic Transmission Dysregulation in the Prefrontal Cortex: Pathophysiological Implications. Molecular Psychiatry, 27, 445-465. https://doi.org/10.1038/s41380-021-01092-3 |
| [25] | Ku？ak-Bejda, A., Bejda, G. and Waszkiewicz, N. (2021) Mental Disorders, Cognitive Impairment and the Risk of Suicide in Older Adults. Frontiers in Psychiatry, 12, Article 695286. https://doi.org/10.3389/fpsyt.2021.695286 |
| [26] | Winer, J.R., Deters, K.D., Kennedy, G., et al. (2021) Association of Short and Long Sleep Duration with Amyloid-β Burden and Cognition in Aging. JAMA Neurology, 78, 1187-1196. https://doi.org/10.1001/jamaneurol.2021.2876 |
| [27] | Elsworthy, R.J. and Aldred, S. (2019) Depression in Alz-heimer’s Disease: An Alternative Role for Selective Serotonin Reuptake Inhibitors? Journal of Alzheimer’s Disease, 69, 651-661. https://doi.org/10.3233/JAD-180780 |
| [28] | Huang, M., Liang, Y., Chen, H., et al. (2018) The Role of Fluoxetine in Activating Wnt/β-Catenin Signaling and Repressing β-Amyloid Production in an Alzheimer Mouse Model. Frontiers in Aging Neuroscience, 10, Article 164.
https://doi.org/10.3389/fnagi.2018.00164 |
| [29] | Banerjee, S., Hellier, J., Romeo, R., et al. (2013) Study of the Use of Antidepressants for Depression in Dementia: The HTA-SADD Trial—A Multicentre, Randomised, Double-Blind, Pla-cebo-Controlled Trial of the Clinical Effectiveness and Cost-Effectiveness of Sertraline and Mirtazapine. Health Tech-nology Assessment, 17, 1-166.
https://doi.org/10.3310/hta17070 |
| [30] | Luan, X., Tian, X., Zhang, H., et al. (2019) Exercise as a Prescription for Pa-tients with Various Diseases. Journal of Sport and Health Science, 8, 422-441. https://doi.org/10.1016/j.jshs.2019.04.002 |
| [31] | Burke, M.J., Fried, P.J. and Pascual-Leone, A. (2019) Transcranial Magnetic Stimulation: Neurophysiological and Clinical Applications. Handbook of Clinical Neurology, 163, 73-92.
https://doi.org/10.1016/B978-0-12-804281-6.00005-7 |
