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乳腺癌术后放疗后复发的危险因素及复发模式
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Abstract:
乳腺癌是目前威胁全球女性健康的第一大肿瘤，据全球癌症统计显示，2020年全球新发癌症病例1929万例，其中乳腺癌新增人数达约230万例，发病率首次超过了肺癌，居恶性肿瘤首位。放疗在乳腺癌综合治疗中具有重要的地位，它可以降低高危患者局部复发风险，但仍有8%~14.3%的患者在放疗后出现复发。乳腺癌预后相关影响因素众多，如肿瘤大小、淋巴结转移数目、分子分型、脉管癌栓、年龄、不同治疗手段等。因此在临床上密切关注导致疾病复发的危险因素，并给予有效干预，对降低肿瘤复发、改善患者生存是极为重要的。目前关于乳腺癌术后放疗后复发模式与乳腺癌相关危险因素的研究存在差异，因此本文旨在探讨乳腺癌术后放疗后相关复发模式与乳腺癌相关危险因素的关系，以期为临床运用提供参考。
Breast cancer is currently the number one tumor threatening women’s health worldwide. Accord-ing to global cancer statistics, in 2020, there were 19.29 million new cancer cases worldwide, of which the number of new breast cancer cases reached about 2.3 million, and the incidence rate ex-ceeded lung cancer for the first time, ranking the first in malignant tumors. Radiotherapy has an important position in the comprehensive treatment of breast cancer, which can reduce the risk of local recurrence in high-risk patients, but there are still 8% to 14.3% of patients who experience recurrence after radiotherapy. There are numerous influencing factors related to the prognosis of breast cancer, such as tumor size, number of lymph node metastases, molecular staging, vascular cancer embolism, age, and different treatments. Therefore, it is extremely important to pay close attention to the risk factors that lead to recurrence of the disease and provide effective intervention to reduce tumor recurrence and improve patient survival. At present, there are differences in the studies on the recurrence pattern after postoperative radiotherapy for breast cancer and the risk factors associated with breast cancer, so this paper aims to explore the relationship between the recurrence pattern associated with postoperative radiotherapy for breast cancer and the risk fac-tors associated with breast cancer, with a view to providing a reference for clinical application.
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