Objective: To investigate the occurrence of PTSD in pre-hospital emergency nurses and its related factors, and to compare the differences of neurotransmitter and immune-related factors between pre-hospital emergency nurses who experienced traumatic events and those who did not develop PTSD and healthy people. How: Post-traumatic Stress Disorder Self-Rating Scale (PCL-C) tests were performed on pre-hospital emergency nurses in PTSD group, non-PTSD group and healthy control group, and the plasma monoamine neurotransmitters and serum cytokines were determined by double-antibody sandwich ABC-ELISA assay using enzyme-linked adsorption kit provided by Shanghai Xitang Biotechnology Co., Ltd. Results: 1) There were statistically significant differences in PCL-C scores between PTSD group, non-PTSD group and healthy group (p < 0.05); 2) There were significant differences in the levels of serum cytokines IL-2, IL-6, IL-10 and TNF-α between PTSD group, non-PTSD group and healthy group (p < 0.05); 3) There were significant differences in plasma levels of monoamine neurotransmitters norepinephrine, 5-hydroxytryptamine and dopamine between PTSD group, non-PTSD group and healthy group (p < 0.05). Conclusion: Pre-hospital emergency nurses should have early psychological intervention and guidance to reduce the occurrence of PTSD in emergency and emergency nurses.
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