外周血总胆汁酸、补体C1q以及体重指数与胆汁反流性胃炎伴肠上皮化生关系的研究
Study on the Relationship between Total Bile Acids, Complement C1q and Body Mass Index in Peripheral Blood and Bile Reflux Gastritis with Intestinal Metaplasia

目的：评价外周血的总胆汁酸(total bile acid, TBA)、补体C1q (complement C1q)水平以及体重指数(body mass index, BMI)对胆汁反流性胃炎(bile reflux gastritis, BRG)伴有肠上皮化生(intestinal metaplasia, IM)的诊断效能。方法：选取2021年9月至2023年10月期间在青岛市市立医院消化内科住院的BRG患者共200例，所有患者均行胃镜检查及胃黏膜组织活检，根据病理结果分为IM发生组(观察组)和IM未发生(对照组)。分别检测两组患者的外周血TBA、补体C1q水平以及体重指数。结果：观察组外周血TBA、补体C1q水平以及体重指数均显著高于对照组(P < 0.05)。外周血TBA、补体C1q水平以及体重指数单个项目在BRG伴IM的检测灵敏度为74.0%，准确度为77.50%；联合检测三个项目的灵敏度为88.89%、特异度为87.69%、准确度为88.50%。结论：外周血TBA、补体C1q水平以及体重指数对BRG伴IM及IM不同分型均具有较好诊断效能，且外周血TBA、补体C1q以及体重指数的侵入性小且方便，对于协助人群诊断BRG伴IM及IM不同分型具有重要的临床价值。
Objective: To evaluate the diagnostic efficacy of total bile acid (TBA), complement C1q and body mass index (BMI) in peripheral blood for bile reflux gastritis (BRG) complicated with intestinal metaplasia (IM). Methods: A total of 200 BRG patients hospitalized in the Gastroenterology De-partment of Qingdao Municipal Hospital from September 2021 to October 2023 were selected. All patients underwent gastroscopy and gastric mucosal tissue biopsy, and were divided into the IM occurrence group (observation group) and the IM non-occurrence group (control group) according to the pathological results. The peripheral blood TBA, complement C1q levels and body mass index of the two groups were measured. Results: The levels of TBA in peripheral blood, complement C1q and body mass index in the observation group were significantly higher than those in the control group (P < 0.05). The sensitivity and accuracy of peripheral blood TBA, complement C1q level and body mass index in BRG with IM were 74.0% and 77.50%. The sensitivity, specificity and accuracy of the three items were 88.89%, 87.69% and 88.50%. Conclusion: The levels of TBA in peripheral blood, complement C1q and body mass index have good diagnostic efficacy in the diagnosis of BRG with IM and different types of IM, and the invasiveness of TBA in peripheral blood, complement C1q and body mass index is small and convenient, which has important clinical value in assisting the population in diagnosing BRG with IM and different types of IM.