We
study afresh how the glucose control system anomalies impact the organicity of
the glucose homeostasis and build up events of persistent hyperglycemia and
diabetes mellitus. We have used critically the state of art literature related
to the subject, in order to cross, to compare, and to organize the relevant
contents to create a logical and consistent support to the finds. We show that
it is consistent to assume that persistent hyperglycemia and diabetes mellitus
can have precursors not only in pancreas, but also in brain, mainly induced by
noxious dysfunctions of hypothalamus sensor neurons circuits and external
noxious elements, causing pancreas overload, and the consequent exhaustion—overburden.
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