This study explores the efficacy of
advanced antibiotic compounds against P. aeruginosa, focusing on Antibiotic B,
an enhanced derivative of Ceftriaxone. The study measured the intracellular
uptake of Antibiotic B and introduced a novel adjuvant, Influximax, which
augmented its antibacterial activity. Results showed a diminished potential for
resistance emergence with Antibiotic B, particularly when used in combination
with Influximax. The study suggests that optimizing antibiotic delivery into
bacterial cells and leveraging syner-gistic adjuvant combinations can enhance
drug resistance combat.
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