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血小板相关指标在假体周围感染诊断中的研究进展
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Abstract:
假体周围感染(Periprosthetic Joint Infection, PJI)作为关节置换术后常见的并发症之一，早期的诊断可以极大改善病人生活质量及降低治疗负担。虽然PJI的诊断近年来得到不断的完善和发展，但目前仍是一个难题，它需要血清学、组织病理学、影像学等各方面检验、检查结果进行综合判断，需要较高的检查费用且经常是有创检查；近年来，越来越多学者认为血小板相关指标对于假体周围感染有一定的早期筛查、诊断价值，并且有许多文章报道了血小板相关指标对PJI有较高的敏感性与特异性，这种血液指标的检验既简便快捷，又有数字化的检验结果，有较高的准确性，可以将其作为早期诊断PJI的参考工具。
Periprosthetic Joint Infection (PJI) is a common complication that can occur after arthroplasty. Early diagnosis of PJI is crucial as it can significantly improve patients’ quality of life and reduce the bur-den of treatment. Although the diagnosis of periprosthetic joint infection (PJI) has improved in re-cent years, it remains a challenging problem. It requires a comprehensive assessment of serology, histopathology, imaging, and other test and examination results. This comprehensive approach of-ten incurs high examination costs and is invasive. In recent years, an increasing number of scholars have recognized the potential of platelet-related indexes in the early screening and diagnosis of PJI. Numerous articles have reported that platelet-related indexes exhibit high sensitivity and specific-ity for PJI. Moreover, the blood test for these indexes is simple, quick, and provides accurate digital results. Therefore, platelet-related indexes can serve as a valuable reference tool for the early di-agnosis of PJI.
| [1] | Hooper, G. (2013) The Ageing Population and the Increasing Demand for Joint Replacement. The New Zealand Medical Journal, 126, 5-6. |
| [2] | Cretu, B., Iordache, S., Cursaru, A., Serban, B., Costache, M., Cirstoiu, C., et al. (2023) Meta-genomic Next-Generation Sequencing for Periprosthetic Joint Infections. Cureus, 15, e38726. https://doi.org/10.7759/cureus.38726 |
| [3] | Caldwell, M., Hughes, M., Wei, F., Ngo, C., Pascua, R., Pugazhendhi, A.S., et al. (2023) Promising Applications of D-Amino Acids in Periprosthetic Joint Infection. Bone Research, 11, Arti-cle No. 14.
https://doi.org/10.1038/s41413-023-00254-z |
| [4] | J？msen, E., Nevalainen, P., Eskelinen, A., Huotari, K., Kal-liovalkama, J. and Moilanen, T. (2012) Obesity, Diabetes, and Preoperative Hyperglycemia as Predictors of Periprosthet-ic Joint Infection: A Single-Center Analysis of 7181 Primary Hip and Knee Replacements for Osteoarthritis. The Journal of Bone & Joint Surgery, 94, e101.
https://doi.org/10.2106/JBJS.J.01935 |
| [5] | Courtney, P.M., Rozell, J.C., Melnic, C.M., Sheth, N.P. and Nelson, C.L. (2016) Effect of Malnutrition and Morbid Obesity on Complication Rates following Primary Total Joint Arthro-plasty. Journal of Surgical Orthopaedic Advances, 25, 99-104. https://doi.org/10.3113/JSOA.2016.0099 |
| [6] | Izakovicova, P., Borens, O. and Trampuz, A. (2019) Periprosthetic Joint Infection: Current Concepts and Outlook. EFORT Open Reviews, 4, 482-494. https://doi.org/10.1302/2058-5241.4.180092 |
| [7] | Sigmund, I.K., Puchner, S.E. and Windhager, R. (2021) Serum Inflammatory Biomarkers in the Diagnosis of Periprosthetic Joint Infections. Biomedicines, 9, Article 1128. https://doi.org/10.3390/biomedicines9091128 |
| [8] | Li, C., Renz, N., Trampuz, A. and Ojeda-Thies, C. (2020) Twenty Common Errors in the Diagnosis and Treatment of Periprosthetic Joint Infection. International Orthopaedics, 44, 3-14. https://doi.org/10.1007/s00264-019-04426-7 |
| [9] | Alrayes, M.M. and Sukeik, M.T. (2023) Emerging Tech-nologies in Diagnosing Periprosthetic Joint Infections. Indian Journal of Orthopaedics, 57, 643-652. https://doi.org/10.1007/s43465-023-00891-w |
| [10] | The Workgroup Convened by the Musculoskeletal Infection So-ciety (2011) New Definition for Periprosthetic Joint Infection. The Journal of Arthroplasty, 26, 1136-1138. https://doi.org/10.1016/j.arth.2011.09.026 |
| [11] | 李睿, 陈继营. 人工关节置换术后假体周围感染诊断方法的研究进展[J]. 中华骨科杂志, 2016, 36(19): 1254-1262. |
| [12] | Riccio, G., Cavagnaro, L., Akkouche, W., Carrega, G., Felli, L. and Burastero, G. (2018) Qualitative α-Defensin Versus the Main Available Tests for the Diagnosis of Periprosthetic Joint Infection: Best Predictor Test? Journal of Bone and Joint Infection, 3, 156-164. https://doi.org/10.7150/jbji.26401 |
| [13] | Huang, Z., Zhang, Z., Li, M., Li, W., Fang, X. and Zhang, W. (2022) Syno-vial Fluid Neutrophil Gelatinase-Associated Lipocalin Can Be Used to Accurately Diagnose Prosthetic Joint Infection. International Journal of Infectious Diseases, 123, 170-175. https://doi.org/10.1016/j.ijid.2022.08.009 |
| [14] | Cao, H.R., Ye, P.C., Jie, K., Zeng, J.C., Feng, W.J., Chen, J.L., Qi, X.Y., Li, J., Tan, X.Q., Zhang, H.T. and Zeng, Y.R. (2020) Platelet Count as a Novel Potential Predictor of Periprosthetic Joint Infection. Chinese Journal of Tissue Engi-neering Research, 24, 4795-4801. |
| [15] | Paziuk, T., Rondon, A.J., Goswami, K., Tan, T.L. and Parvizi, J. (2020) A Novel Adjunct Indicator of Periprosthetic Joint Infection: Platelet Count and Mean Platelet Volume. The Journal of Ar-throplasty, 35, 836-839.
https://doi.org/10.1016/j.arth.2019.10.012 |
| [16] | Mandel, J., Casari, M., Stepanyan, M., Martyanov, A. and Dep-permann, C. (2022) Beyond Hemostasis: Platelet Innate Immune Interactions and Thromboinflammation. International Journal of Molecular Sciences, 23, Article 3868.
https://doi.org/10.3390/ijms23073868 |
| [17] | Maouia, A., Rebetz, J., Kapur, R. and Semple, J.W. (2020) The Immune Nature of Platelets Revisited. Transfusion Medicine Reviews, 34, 209-220. https://doi.org/10.1016/j.tmrv.2020.09.005 |
| [18] | Sabrkhany, S., Kuijpers, M.J.E., Oude Egbrink, M.G.A. and Griffioen, A.W. (2021) Platelets as Messengers of Early-Stage Cancer. Cancer Metastasis Reviews, 40, 563-573. https://doi.org/10.1007/s10555-021-09956-4 |
| [19] | Kirschenbaum, L.A., McKevitt, D., Rullan, M., Reisbeck, B., Fujii, T. and Astiz, M.E. (2004) Importance of Platelets and Fibrinogen in Neutrophil-Endothelial Cell Interactions in Septic Shock. Critical Care Medicine, 32, 1904-1909.
https://doi.org/10.1097/01.CCM.0000139918.80602.57 |
| [20] | Gasparyan, A.Y., Ayvazyan, L., Mukanova, U., Yes-sirkepov, M. and Kitas, G.D. (2019) The Platelet-to-Lymphocyte Ratio as an Inflammatory Marker in Rheumatic Diseas-es. Annals of Laboratory Medicine, 39, 345-357.
https://doi.org/10.3343/alm.2019.39.4.345 |
| [21] | Ludwig, N., Hilger, A., Zarbock, A. and Rossaint, J. (2022) Plate-lets at the Crossroads of Pro-Inflammatory and Resolution Pathways during Inflammation. Cells, 11, Article 1957. https://doi.org/10.3390/cells11121957 |
| [22] | Couldwell, G. and Machlus, K.R. (2019) Modulation of Megakaryo-poiesis and Platelet Production during Inflammation. Thrombosis Research, 179, 114-120. https://doi.org/10.1016/j.thromres.2019.05.008 |
| [23] | Greig, D., Trikha, R., Sekimura, T., Cevallos, N., Kelley, B.V., Mamouei, Z., et al. (2021) Platelet Deficiency Represents a Modifiable Risk Factor for Periprosthetic Joint Infection in a Preclinical Mouse Model. The Journal of Bone and Joint Surgery, 103, 1016-1025. https://doi.org/10.2106/JBJS.20.01428 |
| [24] | Xu, H., Xie, J., Yang, J., Chen, G., Huang, Q. and Pei, F. (2020) Plasma Fibrinogen and Platelet Count Are Referable Tools for Diagnosing Periprosthetic Joint Infection: A Single-Center Retrospective Cohort Study. The Journal of Arthroplasty, 35, 1361-1367. https://doi.org/10.1016/j.arth.2019.12.015 |
| [25] | Wu, Y.Y., Zhang, X., Qin, Y.Y., Qin, J.Q. and Lin, F.Q. (2019) Mean Platelet Volume/Platelet Count Ratio in Colorectal Cancer: A Retrospective Clinical Study. BMC Cancer, 19, Arti-cle No. 314.
https://doi.org/10.1186/s12885-019-5504-9 |
| [26] | Oh, G.H., Chung, S.P., Park, Y.S., Hong, J.H., Lee, H.S., Chung, H.S., et al. (2017) Mean Platelet Volume to Platelet Count Ratio as a Promising Predictor of Early Mortality in Severe Sepsis. Shock, 47, 323-330.
https://doi.org/10.1097/SHK.0000000000000718 |
| [27] | Tirumala, V., Klemt, C., Xiong, L., Chen, W., van den Kie-boom, J. and Kwon, Y.M. (2021) Diagnostic Utility of Platelet Count/Lymphocyte Count Ratio and Platelet Count/Mean Platelet Volume Ratio in Periprosthetic Joint Infection following Total Knee Arthroplasty. The Journal of Arthroplasty, 36, 291-297.
https://doi.org/10.1016/j.arth.2020.07.038 |
| [28] | Korniluk, A., Koper-Lenkiewicz, O.M., Kamińska, J., Kemona, H. and Dymicka-Piekarska, V. (2019) Mean Platelet Volume (MPV): New Perspectives for an Old Marker in the Course and Prognosis of Inflammatory Conditions. Mediators of Inflammation, 2019, Article ID: 9213074. https://doi.org/10.1155/2019/9213074 |
| [29] | Shang, G., Fei, Z., Xu, H., Wang, Y. and Xiang, S. (2022) Globulin and Albumin to Globulin Ratio Precisely Diagnose Periprosthetic Joint Infection and Determine the Timing of Sec-ond-Stage Reimplantation. Journal of Orthopaedic Surgery and Research, 17, Article No. 12. https://doi.org/10.1186/s13018-021-02899-0 |
| [30] | Sahin, E., Karaismailoglu, B., Ozsahin, M.K., Guven, M.F. and Kaynak, G. (2021) Low Value of Platelet Count to Mean Platelet Volume Ratio to Diagnose Chronic PJI: A Case Control Study. Orthopaedics & Traumatology, Surgery & Research, 107, Article ID: 102899. https://doi.org/10.1016/j.otsr.2021.102899 |
| [31] | Huang, J.C., Chen, X., Qiang, S., Zheng, W.D., Zheng, J. and Jin, Y. (2021) Exciting Performance of Plasma Fibrinogen in Periprosthetic Joint Infection Diagnosis. Orthopaedic Surgery, 13, 812-816. https://doi.org/10.1111/os.12964 |
| [32] | Jenne, C.N. and Kubes, P. (2015) Platelets in Inflammation and Infection. Platelets, 26, 286-292.
https://doi.org/10.3109/09537104.2015.1010441 |
| [33] | Yoldas, H. and Karagoz, I. (2019) Association between Hemogram Derived Indices and Culture Positive Infections in Intensive Care Population. Bratislava Medical Journal, 120, 856-859. https://doi.org/10.4149/BLL_2019_142 |
| [34] | Zhang, Z., Xu, X., Ni, H. and Deng, H. (2014) Platelet Indices Are Novel Predictors of Hospital Mortality in Intensive Care Unit Patients. Journal of Critical Care, 29, 885.e1-885.e6. https://doi.org/10.1016/j.jcrc.2014.04.020 |
| [35] | Qiao, L. and Sun, S. (2021) A Retrospective Com-parison of Thromboelastography and Conventional Coagulation Parameters for Periprosthetic Joint Infection Diagnosis and Reimplantation Timing. Clinica Chimica Acta, 519, 118-125.
https://doi.org/10.1016/j.cca.2021.04.014 |
