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维生素K对帕金森病的影响
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Abstract:
帕金森病(Parkinson’s disease, PD)是一种慢性神经系统疾病，主要影响患者的运动能力和协调自主能力。目前这些症状源于大脑中的黑质细胞变性死亡，导致神经递质多巴胺的减少。除此之外，铁沉积、氧化应激和脂质过氧化损伤在帕金森病中的致病作用也逐渐被认知。维生素K对苯二酚是维生素K的完全还原形式，可作为一种抗氧化剂，在防止细胞凋亡，氧化应激和小胶质细胞的激活、神经元细胞电子传递作用等方面都很有前途。但是对于维生素K对帕金森病的发病机制及治疗关系的研究非常有限，仍需通过大量临床实验及动物实验进一步研究。
Parkinson’s disease (PD) is a chronic neurological disorder that primarily affects movement and coordination. The current symptoms stem from the degeneration and death of cells in the substan-tia nigra in the brain, resulting in a decrease in the neurotransmitter dopamine. In addition, iron overload, elevated oxidative stress and lipid peroxidation damage are further significant features of Parkinson’s pathophysiology. Vitamin K (vitamin K hydroquinone, VKH2) is a completely reduced form of vitamin K, which acts as an antioxidant and is promising in preventing apoptosis, oxidative stress and activation of microglia, and electron transfer in neuronal cells. However, the research on the pathogenesis and treatment relationship of vitamin K to Parkinson’s disease is very limited, and it still needs to be further studied through a large number of clinical experiments and animal ex-periments.
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