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血清炎症因子与子宫颈癌相关性研究(综述)
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Abstract:
宫颈癌(Cervical Cancer, CC)是世界范围中最常见的女性恶性肿瘤。为了对宫颈癌患者进行精确的个体化治疗，除加强生殖健康教育外，须采取相应的预防措施及早诊断早治疗，同时迫切需要找到合适的标记物进行较为准确的预后评估。当前大多数研究认为中性粒细胞、淋巴细胞、血小板等血液参数指标参与了肿瘤的形成进展以及转移的全过程。本文将围绕中性粒淋巴细胞比值(Neutrophil to Lymphocyte Ratio, NLR)、血小板淋巴细胞比值(Platelet to Lymphocyte Ratio, PLR)展开讨论，详细阐述术前血清学检测与宫颈癌发生、发展的相关性。
Cervical cancer (CC) is the most common female malignant tumor worldwide. In order to accurately individualize the treatment of cervical cancer patients, in addition to strengthening reproductive health education, it is necessary to take appropriate preventive measures for early diagnosis and treatment, and there is an urgent need to find appropriate markers for more accurate prognosis assessment. Most of the current studies believe that blood parameters such as neutrophils, lym-phocytes and platelets are involved in the whole process of tumor formation and progression as well as metastasis. In this paper, we will discuss the Neutrophil to Lymphocyte Ratio (NLR) and Platelet to Lymphocyte Ratio (PLR), and elaborate the correlation between preoperative serologic testing and cervical cancer occurrence and development.
| [1] | Torre, L.A., Bray, F., Siegel, R.L., Ferlay, J., Lortet-Tieulent, J. and Jemal, A. (2015) Global Cancer Statistics, 2012. CA: A Cancer Journal for Clinicians, 65, 87-108. https://doi.org/10.3322/caac.21262 |
| [2] | Jemal, A., Bray, F., Center, M.M., Ferlay, J., Ward, E. and Forman, D. (2011) Global Cancer Statistics. CA: A Cancer Journal for Clinicians, 61, 69-90. https://doi.org/10.3322/caac.20107 |
| [3] | Sung, H., Ferlay, J., Siegel, R.L., et al. (2021) Global Cancer Sta-tistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71, 209-249.
https://doi.org/10.3322/caac.21660 |
| [4] | Xue, L.B., Liu, Y.H., Zhang, B., et al. (2019) Prognostic Role of High Neytrophil-to-Lymphocyte Ratio in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy: Meta-Analysis. Medi-cine (Baltimore), 98, e13842.
https://doi.org/10.1097/MD.0000000000013842 |
| [5] | Mantovani, A., Allavena, P., Sica, A., et al. (2008) Can-cer-Related Inflammation. Nature, 454, 436-444.
https://doi.org/10.1038/nature07205 |
| [6] | Diakos, C.I., Charles, K.A., Mcmillan, D.C., et al. (2014) Cancer-Related Inflammation and Treatment Effectiveness. The Lancet Oncology, 15, e493-e503. https://doi.org/10.1016/S1470-2045(14)70263-3 |
| [7] | Alhabbab, R.Y., Nova-Lamperti, E., Aravena, O., Burton, H.M., Lechler, R.I., Dorling, A. and Lombardi, G. (2019) Regulatory B Cells: Development, Phenotypes, Functions, and Role in Transplantation. Immunological Reviews, 292, 164-179. https://doi.org/10.1111/imr.12800 |
| [8] | Sautès-Fridman, C., Verneau, J., Sun, C.M., et al. (2020) Tertiary Lym-phoid Structures and B Cells: Clinical Impact and Therapeutic Modulation in Cancer. Seminars in Immunology, 48, Arti-cle ID: 101406.
https://doi.org/10.1016/j.smim.2020.101406 |
| [9] | Ladányi, A., Papp, E., Mohos, A., et al. (2020) Role of the Ana-tomic Site in the Association of HLA Class I Antigen Expression Level in Metastases with Clinical Response to Ipili-mumab Therapy in Patients with Melanoma. The Journal for ImmunoTherapy of Cancer, 8, e000209. https://doi.org/10.1136/jitc-2019-000209 |
| [10] | Grivennikov, S.I., Greten, F.R. and Karin, M. (2010) Immunity, In-flammation and Cancer. Cell, 140, 883-899.
https://doi.org/10.1016/j.cell.2010.01.025 |
| [11] | Johnson, K.E., Mcakkuster, S.S., Italiano, J.E., et al. (2017) The Role of Platelets in the Tumor Microenvironment. International Journal of Cancer, 11, 125-127. https://doi.org/10.1007/978-3-319-39147-2_12 |
| [12] | Hanahan, D. and Weinberg, R.A. (2011) Hallmarks of Cancer: The Next Generation. Cell, 144, 646-674.
https://doi.org/10.1016/j.cell.2011.02.013 |
| [13] | 冯晴, 方吉, 陈雪丹. 术前炎症指标对肝细胞癌肝切除术患者的预后预测价值[J]. 中国癌症防治杂志, 2021, 13(5): 529-533. |
| [14] | 陈万臣, 辛莘, 郭雅丽, 等. 术前外周血NLR、PLR、RDW水平检测对结直肠癌早期诊断的应用价值[J]. 解放军医药杂志, 2022, 34(5): 15-17. |
| [15] | 张晓芳, 王伟刚, 徐晓琴, 等. 子宫颈癌患者术前外周血中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值及免疫指标与预后的相关性[J]. 肿瘤研究与临床, 2023, 35(7): 515-520. |
| [16] | 郑强, 赵斌, 杜鹏, 等. 全身免疫炎症指数与胃癌相关性的研究进展[J]. 现代医学, 2022, 50(11): 1475-1481. |
| [17] | Selders, G.S., Fetz, A.E., Radic, M.Z. and Bowlin, G.L. (2017) An Overview of the Role of Neutrophils in Innate Immunity, Inflammation and Host-Biomaterial Integration. Regenerative Biomaterials, 4, 55-68.
https://doi.org/10.1093/rb/rbw041 |
| [18] | Galdiero, M.R., Bonavita, E., Barajon, I., Garlanda, C., Mantovani, A. and Jaillon, S. (2013) Tumor Associated Macrophages and Neutrophils in Cancer. Immunobiology, 218, 1402-1410. https://doi.org/10.1016/j.imbio.2013.06.003 |
| [19] | Fridlender, Z.G., Sun, J., Kim, S., Kapoor, V., Cheng, G., Ling, L., Worthen, G.S. and Albelda, S.M. (2009) Polarization of Tumor-Associated Neutrophil Phenotype by TGF-Beta: “N1” versus “N2” TAN. Cancer Cell, 16, 183-194.
https://doi.org/10.1016/j.ccr.2009.06.017 |
| [20] | Andzinski, L., Kasnitz, N., Stahnke, S., Wu, C.F., Gereke, M., von K？ckritz-Blickwede, M., Schilling, B., Brandau, S., Weiss, S. and Jablonska, J. (2016) Type I IFNs Induce Anti-Tumor Polarization of Tumor Associated Neutrophils in Mice and Human. International Journal of Cancer, 138, 1982-1993. https://doi.org/10.1002/ijc.29945 |
| [21] | Kitamura, T., Qian, B.Z. and Pollard, J.W. (2015) Immune Cell Promotion of Metastasis. Nature Reviews Immunology, 15, 73-86. https://doi.org/10.1038/nri3789 |
| [22] | Deryugina, E.I., Zajac, E., Juncker-Jensen, A., et al. (2014) Tissue-Infiltrating Neutrophils Constitute the Major in Vivo Source of Angiogene-sis-Inducing MMP-9 in the Tumor Microenvironment. Neoplasia, 16, 771-788.
https://doi.org/10.1016/j.neo.2014.08.013 |
| [23] | 王健, 韩忠燕, 周娜. CXCL8及其受体CXCR1、CXCR2在慢性乙肝患者外周血PMNs中的表达[J]. 中国免疫学杂志, 2015, 31(3): 375-379+383. |
| [24] | Zhang, Y., Shen, Y., Cao, B., Yan, A. and Ji, H. (2015) Elevated Expression Levels of Androgen Receptors and Matrix Metalloproteinase-2 and -9 in 30 Cases of Hepatocellular Carcinoma Compared with Adjacent Tissues as Predictors of Cancer Invasion and Staging. Experimental and Therapeutic Medicine, 9, 905-908.
https://doi.org/10.3892/etm.2014.2150 |
| [25] | Houghton, A.M., Rzymkiewicz, D.M., Ji, H., Gregory, A.D., Egea, E.E., Metz, H.E., et al. (2010) Neutrophil Elastase-Mediated Degradation of IRS-1 Accelerates Lung Tumor Growth. Nature Medicine, 16, 219-223.
https://doi.org/10.1038/nm.2084 |
| [26] | Kim, J. and Bae, J.S. (2016) Tumor-Associated Macrophages and Neutro-phils in Tumor Microenvironment. Mediators of Inflammation, 2016, Article ID: 6058147. https://doi.org/10.1155/2016/6058147 |
| [27] | Spiegel, A., Brooks, M.W., Houshyar, S., Reinhardt, F., Ardolino, M., Fessler, E., et al. (2016) Neutrophils Suppress Intraluminal NK Cell-Mediated Tumor Cell Clearance and Enhance Ex-travasation of Disseminated Carcinoma Cells. Cancer Discovery, 6, 630-649. https://doi.org/10.1158/2159-8290.CD-15-1157 |
| [28] | 叶德宇, 杨帅, 赵龙龙, 孟宪瑛. 炎性标志物对恶性肿瘤发生发展和预后的影响及其机制的研究进展[J]. 吉林大学学报(医学版), 2022, 48(4): 1079-1087. |
| [29] | Levin, J. and Conley, C.L. (1964) Thrombocytosis Associated with Malignant Disease. Archives of Internal Medicine, 114, 497-500. https://doi.org/10.1001/archinte.1964.03860100079008 |
| [30] | Gasic, G.J., Gasic, T.B., Galanti, N., et al. (1973) Platelet-Tumor-Cell Interactions in Mice. The Role of Platelets in the Spread of Malignant Disease. International Journal of Cancer, 11, 704-718. https://doi.org/10.1002/ijc.2910110322 |
| [31] | Oshima, M., Okano, K., Suto, H., et al. (2020) Changes and Prognostic Impact of Inflammatory Nutritional Factors during Neoadjuvant Chemoradiotherapy for Patients with Resectable and Borderline Resectable Pancreatic Cancer. BMC Astroenterology, 20, Article No. 423. https://doi.org/10.1186/s12876-020-01566-8 |
| [32] | Olusola, P., Banerjee, H.N., Philley, J.V. and Dasgupta, S. (2019) Human Papilloma Virus-Associated Cervical Cancer and Health Disparities. Cells, 8, Article No. 622. https://doi.org/10.3390/cells8060622 |
| [33] | Zhou, Z.W., Long, H.Z., Cheng, Y., Luo, H.Y., Wen, D.D. and Gao, L.C. (2021) From Microbiome to Inflammation: The Key Drivers of Cervical Cancer. Frontiers in Microbiology, 12, Ar-ticle ID: 767931.
https://doi.org/10.3389/fmicb.2021.767931 |
| [34] | Shafabakhsh, R., Pourhanifeh, M.H., Mirzaei, H.R., Sahebkar, A., Asemi, Z. and Mirzaei, H. (2019) Targeting Regulatory T Cells by Curcumin: A Potential for Cancer Immunotherapy. Pharmacological Research, 147, Article ID: 104353.
https://doi.org/10.1016/j.phrs.2019.104353 |
| [35] | Lages, E.L., Belo, A.V., Andrade, S.P., Rocha, M.？., de Freitas, G.F., Lamaita, R.M., Traiman, P. and Silva-Filho, A.L. (2011) Analysis of Systemic Inflammatory Response in the Car-cinogenic Process of Uterine Cervical Neoplasia. Biomedicine & Pharmacotherapy, 65, 496-499. https://doi.org/10.1016/j.biopha.2011.06.010 |
| [36] | Abakumova, T.V., Antoneeva, I.I., Gening, T.P., Gening, S.O., Dolgova, D.R. and Fomina, A.V. (2014) Cytokines Profile and Metabolic Activity of Neutrophils of Peripheral Blood When Progressing Neoplasma. Patologicheskaia Fiziologiia i Eksperimental’naia Terapiia, No. 4, 86-90. (In Rus-sian) |
| [37] | 颜彬, 陈慧君, 高晗, 等. 肿瘤相关CD66b阳性中性粒细胞对预测宫颈癌Ib至IIa期复发的价值[J]. 中国肿瘤临床, 2017, 44(21): 1071-1075. |
| [38] | Huang, Q.T., Man, Q.Q., Hu, J., Yang, Y.L., Zhang, Y.M., Wang, W., Zhong, M. and Yu, Y.H. (2017) Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Cervical Cancer: A Sys-tematic Review and Meta-Analysis of Observational Studies. Oncotarget, 8, 16755-16764. https://doi.org/10.18632/oncotarget.15157 |
| [39] | Mizunuma, M., Yokoyama, Y., Futagami, M., Aoki, M., Takai, Y. and Mizunuma, H. (2015) The Pretreatment Neutrophil-to-Lymphocyte Ratio Predicts Therapeutic Response to Radiation Therapy and Concurrent Chemoradiation Therapy in Uterine Cervical Cancer. International Journal of Clinical Oncology, 20, 989-996.
https://doi.org/10.1007/s10147-015-0807-6 |
