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血糖波动与认知功能障碍关系的研究进展
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Abstract:
认知功能障碍是指高级智力加工过程中出现的异常，包括学习、记忆和批判性思维。随着全球人口老龄化，认知功能障碍得到社会各界更多的关注。痴呆症作为认知功能下降的尾章，致残率高且代价高昂。血糖波动是近年来糖尿病领域关注的热点，又称血糖漂移。血糖正常波动属于正常生理现象，但作为异常病理现象的异常血糖波动往往对机体有损害。近年来的研究发现血糖波动与认知功能障碍的发生关系微妙。基于此，本文对血糖波动的定义、常见原因以及认知功能的定义和其发展进行总结，分析血糖波动与认知功能障碍的可能机制，以期阐明血糖波动与认知功能障碍的关系，减少血糖波动，尽早发现、干预并延缓认知功能的减退。
Cognitive dysfunction refers to abnormalities in higher intellectual processing, which includes learning, memory and critical thinking. As the global population ages, cognitive dysfunction got more attention from all sectors of society. Dementia, the tail chapter of cognitive decline, is disa-bling and costly. Blood glucose fluctuations had been a hot topic of interest in the field of diabetes, it can also be referred to as blood sugar drift. Normal blood glucose fluctuations are normal physio-logical phenomena, but abnormal blood glucose fluctuation as an abnormal pathology are often damaging to the body. In recent years, a plenty of research found that fluctuating blood glucose has a subtle relationship with cognitive impairment. Based on that, this paper summarised the defini-tion and common causes of blood sugar fluctuations, as well as the definition and development of cognitive function. It also analysed the possible mechanisms of blood sugar fluctuations and cogni-tive dysfunction, in order to clarify the relationship between blood sugar fluctuations and cognitive dysfunction, and try to reduce blood sugar fluctuations and detect, intervene, and delay cognitive decline as early as possible.
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