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阴道上皮内瘤变治疗进展
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Abstract:
阴道上皮内瘤变(VaIN)是一种罕见的相关的浸润前病变。根据2012年修订的下肛门生殖器鳞状上皮术语，它现在被分类为“低度VaIN”(LG-VaIN)或阴道LSIL和“高度VaIN”(HG-VaIN)或阴道HSIL。近年来，阴道细胞学、病毒学和阴道镜检查等筛查手段应用的愈加广泛，阴道残端VaIN的检出率也逐渐增高。虽然有许多治疗模式，如期待治疗，激光消融，切除方式，近距离放射治疗和局部治疗等，但VaIN的管理仍然存在争议。本综述的主要目标是描述VaIN的治疗进展。
Vaginal intraepithelial neoplasia (VaIN) is a rare associated pre-invasive lesion. It is now catego-rized as “low-grade VaIN” (LG-VaIN) or vaginal LSIL and “high-grade VaIN” (HG-VaIN) or vaginal HSIL according to the 2012 revision of the terminology for lower genitourinary squamous epithelium. In recent years, screening tools such as vaginal cytology, virology and colposcopy have become more widely used, and the detection rate of vaginal stump VaIN has gradually increased. Although there are many treatment modalities such as expectant therapy, laser ablation, excisional modalities, brachytherapy and localized therapy, the management of VaIN remains controversial. The main objective of this review is to describe the advances in the treatment of VaIN.
| [1] | Aho, M., Vesterinen, E., Meyer, B., et al. (1991) Natural History of Vaginal Intraepithelial Neoplasia. Cancer, 68, 195-197. https://doi.org/10.1002/1097-0142(19910701)68:1<195::AID-CNCR2820680135>3.0.CO;2-L |
| [2] | Wharton, J.T., Tortolero-Luna, G., Linares, A.C., et al. (1996) Vaginal Intraepithelial Neoplasia and Vaginal Cancer. Obstetrics and Gynecology Clinics of North America, 23, 325-345. |
| [3] | Lu, Z. and Chen, J. (2014) Introduction of WHO Classification of Tumours of Female Reproductive Organs, Fourth Edition. Chinese Journal of Pathology, 43, 649-650. |
| [4] | Kim, J.H., Kim, J., Kim, K., et al. (2022) Risk Factor and Treatment of Vaginal Intraepithelial Neoplasia after Hysterectomy for Cer-vical Intraepithelial Neoplasia. Journal of Lower Genital Tract Disease, 26, 147-151.
https://doi.org/10.1097/LGT.0000000000000664 |
| [5] | Audet-Lapointe, P., Body, G., Vauclair, R., et al. (1990) Vaginal Intraepithelial Neoplasia. Gynecologic Oncology, 36, 232-239. https://doi.org/10.1016/0090-8258(90)90180-S |
| [6] | Thuijs, N.B., van Beurden, M., Bruggink, A.H., et al. (2021) Vulvar Intraepithelial Neoplasia: Incidence and Long-Term Risk of Vulvar Squamous Cell Carcinoma. International Journal of Cancer, 148, 90-98.
https://doi.org/10.1002/ijc.33198 |
| [7] | Zhang, L., Wang, Q., Zhang, H., et al. (2021) Screening History in Vaginal Precancer and Cancer: A Retrospective Study of 2131 Cases in China. Cancer Management and Research, 13, 8855-8863.
https://doi.org/10.2147/CMAR.S335701 |
| [8] | Kim, M.K., Lee, I.H. and Lee, K.H. (2018) Clinical Outcomes and Risk of Recurrence among Patients with Vaginal Intraepithelial Neoplasia: A Comprehensive Analysis of 576 Cases. Journal of Gynecologic Oncology, 29, e6.
https://doi.org/10.3802/jgo.2018.29.e6 |
| [9] | Tainio, K., Jakobsson, M., Louvanto, K., et al. (2016) Randomised Trial on Treatment of Vaginal Intraepithelial Neoplasia-Imiquimod, Laser Vaporisation and Expectant Management. In-ternational Journal of Cancer, 139, 2353-2358.
https://doi.org/10.1002/ijc.30275 |
| [10] | Freitas, G. and Costa, A. (2023) Non-Excisional Therapeutic Modalities in Vaginal Intraepithelial Neoplasia. The European Journal of Obstetrics & Gynecology and Reproductive Biology, 284, 175-179.
https://doi.org/10.1016/j.ejogrb.2023.03.014 |
| [11] | Cui, C., Xiao, Y., Lin, E., et al. (2022) Precise Measurement of the Thickness of Vaginal Intraepithelial Neoplasia. Journal of Lower Genital Tract Disease, 26, 245-249. https://doi.org/10.1097/LGT.0000000000000672 |
| [12] | Sopracordevole, F., De Piero, G., Clemente, N., et al. (2016) Vaginal Intraepithelial Neoplasia: Histopathological Upgrading of Lesions and Evidence of Occult Vaginal Cancer. Journal of Lower Genital Tract Disease, 20, 70-74.
https://doi.org/10.1097/LGT.0000000000000150 |
| [13] | He, M.Y., Yu, E.L., Hui, S.K., et al. (2022) Clinical Out-comes of Laser Vaporization for Vaginal Intraepithelial Neoplasia—A 20-Year Retrospective Review. The European Journal of Obstetrics & Gynecology and Reproductive Biology, 277, 101-109. https://doi.org/10.1016/j.ejogrb.2022.08.017 |
| [14] | Huang, J., Wei, Y., Gu, L., et al. (2023) Feasibility Study of 5-Aminolevulinic Acid Mediated Photodynamic Therapy of Persistent Vaginal High-Risk HPV Infection of Post-Hysterectomy Patients. Photodiagnosis and Photodynamic Therapy, 41, Article ID: 103250. https://doi.org/10.1016/j.pdpdt.2022.103250 |
| [15] | Soergel, P., Wang, X., Stepp, H., et al. (2008) Photodynamic Therapy of Cervical Intraepithelial Neoplasia with Hexaminolevulinate. Lasers in Surgery and Medicine, 40, 611-615. https://doi.org/10.1002/lsm.20686 |
| [16] | Wang, L., Liu, X., Zhang, J., et al. (2023) Comparison of ALA-PDT and CO2 Laser Treatment of Low-Grade Vaginal Intraepithelial Neoplasia with High-Risk HPV Infection: A Non-Randomized Controlled Pilot Study. Photodiagnosis and Photodynamic Therapy, 43, Article ID: 103695. https://doi.org/10.1016/j.pdpdt.2023.103695 |
| [17] | Schon, M.P. and Schon, M. (2007) Imiquimod: Mode of Action. British Journal of Dermatology, 157, 8-13.
https://doi.org/10.1111/j.1365-2133.2007.08265.x |
| [18] | Iavazzo, C., Pitsouni, E., Athanasiou, S., et al. (2008) Imiquimod for Treatment of Vulvar and Vaginal Intraepithelial Neoplasia. International Journal of Gynecology & Ob-stetrics, 101, 3-10. https://doi.org/10.1016/j.ijgo.2007.10.023 |
| [19] | Inayama, Y., Takamatsu, S., Hamanishi, J., et al. (2023) Imiquimod for Cervical and Vaginal Intraepithelial Neoplasia: A Systematic Review and Meta-Analysis. Obstet-rics & Gynecology, 142, 307-318.
https://doi.org/10.1097/AOG.0000000000005256 |
| [20] | Gonzalez-Sanchez, J.L., Flores-Murrieta, G., Deolarte-Melgarejo, J.M., et al. (1998) Effectiveness of 5-Fluorouracil in the Treatment of Vaginal Intraepithelial Neo-plasia in a Mexican Population. Journal of Lower Genital Tract Disease, 2, 221-224. https://doi.org/10.1097/00128360-199810000-00007 |
| [21] | Fiascone, S., Vitonis, A.F. and Feldman, S. (2017) Topical 5-Fluorouracil for Women with High-Grade Vaginal Intraepithelial Neoplasia. Obstetrics & Gynecology, 130, 1237-1243. https://doi.org/10.1097/AOG.0000000000002311 |
| [22] | Rader, J.S., Leake, J.F., Dillon, M.B., et al. (1991) Ultrasonic Surgical Aspiration in the Treatment of Vulvar Disease. Obstetrics & Gynecology, 77, 573-576. https://doi.org/10.1016/0090-8258(91)90122-L |
| [23] | Vanderburgh, E. and Nahhas, W.A. (1990) Debridement of Vaginal Radiation Ulcers Using the Surgical Ultrasonic Aspirator. Gynecologic Oncology, 39, 103-104. https://doi.org/10.1016/0090-8258(90)90410-M |
| [24] | Matsuo, K., Chi, D.S., Walker, L.D., et al. (2009) Ultrasonic Surgical Aspiration for Vaginal Intraepithelial Neoplasia. International Journal of Gynecology & Obstetrics, 105, 71-73. https://doi.org/10.1016/j.ijgo.2008.11.040 |
| [25] | Robinson, J.B., Sun, C.C., Bodurka-Bevers, D., et al. (2000) Cavi-tational Ultrasonic Surgical Aspiration for the Treatment of Vaginal Intraepithelial Neoplasia. Gynecologic Oncology, 78, 235-241.
https://doi.org/10.1006/gyno.2000.5881 |
| [26] | Rader, J.S. and Rosenshein, N.B. (1995) Ultrasonic Surgical Tech-niques for the Pelvic Surgeon. Springer-Verlag, New York. https://doi.org/10.1007/978-1-4612-2486-0 |
| [27] | Bhati, P., Samynathan, K., Sebastian, A., et al. (2019) Proximal Partial Vaginectomy for Vaginal Intraepithelial Neoplasia. The Journal of Obstetrics and Gynecology of India, 69, 160-164.
https://doi.org/10.1007/s13224-018-1158-9 |
| [28] | Indermaur, M.D., Martino, M.A., Fiorica, J.V., et al. (2005) Up-per Vaginectomy for the Treatment of Vaginal Intraepithelial Neoplasia. American Journal of Obstetrics & Gynecology, 193, 577-581.
https://doi.org/10.1016/j.ajog.2005.03.055 |
| [29] | Powell, J.L. and Asbery, D.S. (2000) Treatment of Vaginal Dys-plasia: Just a Simple Loop Electrosurgical Excision Procedure? American Journal of Obstetrics & Gynecology, 182, 731-732. https://doi.org/10.1067/mob.2000.102701 |
| [30] | Fanning, J., Manahan, K.J. and McLean, S.A. (1999) Loop Electrosurgical Excision Procedure for Partial Upper Vaginectomy. American Journal of Obstetrics & Gynecology, 181, 1382-1385.
https://doi.org/10.1016/S0002-9378(99)70379-0 |
