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子宫内膜和卵巢原发性双癌与子宫内膜癌卵巢转移的临床特征对比及分析
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Abstract:
子宫内膜和卵巢原发性双癌在临床上较为少见，易被误诊为原发性子宫内膜癌卵巢转移或原发性卵巢癌子宫内膜转移，其鉴别诊断是临床的一大难点，治疗和预后也存在一定的差异。近几年众多研究表明子宫内膜和卵巢原发性双癌实质是一种转移性疾病，更可能是来源于子宫内膜转移至卵巢，但其预后显著好于原发性子宫内膜癌伴卵巢转移。本文旨在对子宫内膜和卵巢原发性双癌与子宫内膜癌伴卵巢转移的临床表现、分子学特征及治疗对比作综述。
Synchronous primary endometrial and ovarian cancer is relatively rare in clinic, easily misdiag-nosed as primary endometrial cancer with ovarian metastasis or primary ovarian cancer with en-dometrial metastasis, and its differential diagnosis is a major difficulty in clinic, and its treatment and prognosis also have certain differences. In recent years, many studies have shown that syn-chronous primary endometrial and ovarian cancer is essentially a metastatic disease, which is more likely to originate from the endometrium and metastasize to the ovary, but its prognosis is signifi-cantly better than that of primary endometrial cancer with ovarian metastasis. The purpose of this article is to review the clinical manifestations, molecular features and treatment of synchronous primary endometrial and ovarian cancer compared with primary endometrial cancer with ovarian metastasis.
| [1] | Sung, H., Ferlay, J., Siegel, R.L., et al. (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71, 209-249.
https://doi.org/10.3322/caac.21660 |
| [2] | Gilks, C.B. and Kommoss, F. (2018) Synchronous Tumours of the Female Reproductive Tract. Pathology, 50, 214-221. https://doi.org/10.1016/j.pathol.2017.10.007 |
| [3] | Tong, S., Lee, Y., Park, J., et al. (2008) Clinical Analysis of Synchronous Primary Neoplasms of the Female Reproductive Tract. European Journal of Obstetrics & Gynecology and Reproductive Biology, 136, 78-82.
https://doi.org/10.1016/j.ejogrb.2006.09.010 |
| [4] | Dogan, A., Schultheis, B., Rezniczek, G.A., et al. (2017) Syn-chronous Endometrial and Ovarian Cancer in Young Women: Case Report and Review of the Literature. Anticancer Re-search, 37, 969-978.
https://doi.org/10.21873/anticanres.11406 |
| [5] | Sadidi, H., Izadi-Mood, N., Sarmadi, S., et al. (2015) Comparison of Clinicopathologic Variables in Coexistence Cancers of the Endometrium and Ovary: A Review of 55 Cases in an Ac-ademic Center in Iran. Journal of Research in Medical Sciences, 20, 727-732. https://doi.org/10.4103/1735-1995.168315 |
| [6] | Selvaggi, S.M. (2000) Tumors of the Ovary, Maldeveloped Gon-ads, Fallopian Tube, and Broad Ligament. Archives of Pathology & Laboratory Medicine, 124, 477. https://doi.org/10.5858/2000-124-474-TOTOMG |
| [7] | Ulbright, T.M. and Roth, L.M. (1985) Metastatic and Inde-pendent Cancers of the Endometrium and Ovary: A Clinicopathologic Study of 34 Cases. Human Pathology, 16, 28-34. https://doi.org/10.1016/S0046-8177(85)80210-0 |
| [8] | 谢玲玲, 林仲秋. 《2023 NCCN子宫肿瘤临床实践指南(第1版)》解读[J]. 中国实用妇科与产科杂志, 2023, 39(2): 197-204. |
| [9] | Berek, J.S., Matias Guiu, X., Creutzberg, C., et al. (2023) FIGO Staging of Endometrial Cancer: 2023. International Journal of Gynecology & Obstetrics, 162, 383-394. https://doi.org/10.1002/ijgo.14923 |
| [10] | Hájková, N., Tichá, I., Hojny, J., et al. (2019) Synchronous En-dometrioid Endometrial and Ovarian Carcinomas Are Biologically Related: A Clinico-Pathological and Molecular (Next Generation Sequencing) Study of 22 Cases. Oncology Letters, 17, 2207-2214. https://doi.org/10.3892/ol.2018.9855 |
| [11] | Sakamoto, I., Hirotsu, Y., Amemiya, K., et al. (2023) Elucidation of Genomic Origin of Synchronous Endometrial and Ovarian Cancer (SEO) by Genomic and Microsatellite Analysis. Journal of Gynecologic Oncology, 34, e6.
https://doi.org/10.3802/jgo.2023.34.e6 |
| [12] | Reijnen, C., Kusters-Vandevelde, H., Ligtenberg, M., et al. (2020) Molecular Profiling Identifies Synchronous Endometrial and Ovarian Cancers as Metastatic Endometrial Cancer with Favorable Clinical Outcome. International Journal of Cancer, 147, 478-489. https://doi.org/10.1002/ijc.32907 |
| [13] | Yen, T., Wang, T., Fader, A.N., et al. (2020) Molecular Classification and Emerging Targeted Therapy in Endometrial Cancer. International Journal of Gynecological Pathology, 39, 26-35. https://doi.org/10.1097/PGP.0000000000000585 |
| [14] | Wang, T., Zhang, X., Lu, Z., et al. (2019) Comparison and Analysis of the Clinicopathological Features of SCEO and ECOM. Journal of Ovarian Research, 12, Article No. 10. https://doi.org/10.1186/s13048-019-0485-5 |
| [15] | Yang, L., Zhang, L., Huang, Q., et al. (2018) Combination of Scoring Criteria and Whole Exome Sequencing Analysis of Synchronous Endometrial and Ovarian Carcinomas. Interna-tional Journal of Gynecologic Cancer, 28, 704-712.
https://doi.org/10.1097/IGC.0000000000001227 |
| [16] | Guerra, F., Girolimetti, G., Perrone, A.M., et al. (2014) Mi-tochondrial DNA Genotyping Efficiently Reveals Clonality of Synchronous Endometrial and Ovarian Cancers. Modern Pathology, 27, 1412-1420.
https://doi.org/10.1038/modpathol.2014.39 |
| [17] | Heitz, F., Amant, F., Fotopoulou, C., et al. (2014) Synchronous Ovarian and Endometrial Cancer—An International Multicenter Case-Control Study. International Journal of Gynecological Cancer, 24, 54-60.
https://doi.org/10.1097/IGC.0000000000000019 |
| [18] | Brooks, R.A., Fleming, G.F., Lastra, R.R., et al. (2019) Current Recommendations and Recent Progress in Endometrial Cancer. CA: A Cancer Journal for Clinicians, 69, 258-279. https://doi.org/10.3322/caac.21561 |
| [19] | Moro, F., Leombroni, M., Pasciuto, T., et al. (2019) Synchro-nous Primary Cancers of Endometrium and Ovaryvs Endometrial？Cancer？with？Ovarian Metastasis: An Observational Study. Ultrasound in Obstetrics & Gynecology, 53, 827-835. https://doi.org/10.1002/uog.20213 |
| [20] | 邓泽文, 赵祎琪, 罗古坡, 等. 子宫内膜和卵巢原发性双癌与原发性子宫内膜癌伴卵巢转移的临床特征及分析[J]. 四川大学学报(医学版), 2019, 50(2): 268-271. |
| [21] | Matsuo, K., Machida, H., Blake, E.A., et al. (2018) Trends and Outcomes of Women with Synchronous Endometrial and Ovarian Cancer. Oncotarget, 9, 28757-28771. https://doi.org/10.18632/oncotarget.25550 |
| [22] | Hoorshad, N., Nassiri, S., Najibi, S., et al. (2023) Synchronous Endometrial and Ovarian Cancer and Its Recurrent Risk Factors: Case Series. Cancer Treatment and Research Commu-nications, 36, Article ID: 100731.
https://doi.org/10.1016/j.ctarc.2023.100731 |
| [23] | Li, Q. and Zhang, X. (2023) Prediction of High-Risk Factors for Ovarian Metastasis in Patients with Endometrial Cancer: A Large-Sample Retrospective Case-Control Study. Interna-tional Journal of Gynecology & Obstetrics, 161, 144-150. https://doi.org/10.1002/ijgo.14606 |
| [24] | Juhasz-B？ss, I., Haggag, H., Baum, S., et al. (2012) Laparoscopic and Laparotomic Approaches for Endometrial Cancer Treatment: A Comprehensive Review. Archives of Gynecology and Obstetrics, 286, 167-172.
https://doi.org/10.1007/s00404-012-2254-1 |
| [25] | Mouraz, M., Ferreira, C.S., Gon？alves, S., et al. (2019) Laparo-scopic Approach in Surgical Staging of Endometrial Cancer. Revista Brasileira de Ginecologia e Obstetrícia, 41, 306-311. https://doi.org/10.1055/s-0039-1688461 |
| [26] | Mehmet, S.B., ？zer, B., Ceyda, K., et al. (2021) Clinico-pathological Risk Factors and Survival Analysis of Ovarian Cancer with Synchronous Endometrial Cancer Diagnosed after Surgery. European Journal of Gynaecological Oncology, 42, 499-505. https://doi.org/10.31083/j.ejgo.2021.03.2336 |
| [27] | Shin, W., Park, S.Y., Kang, S., et al. (2021) How to Manage Synchronous Endometrial and Ovarian Cancer Patients? BMC Cancer, 21, Article No. 489. https://doi.org/10.1186/s12885-021-08220-w |
| [28] | 杨孝明, 王玉东. 子宫内膜及卵巢双原发癌的研究进展[J]. 中国妇产科临床杂志, 2020, 21(4): 431-433. |
