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糖化血红蛋白在冠心病中的研究进展
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Abstract:
冠心病是人类的“第一大杀手”，我国每年有260万人死于心血管疾病，每12秒就有1人被心血管疾病夺去生命，是我国致残率和致死率最高的疾病之一。糖化血红蛋白(HbA1c)是糖尿病患者长期血糖控制的标志物，HbA1c升高与糖尿病患者心血管事件风险增加有关。结合近几年相关文献对HbA1c与冠心病的发生发展等方面的研究进展进行综述，进而对冠心病的防治提供理论支持。
Coronary heart disease is the “largest killer” of humanity. Every year, 2.6 million people in China die from cardiovascular disease, and one person is killed every 12 seconds by cardiovascular disease. It is one of the diseases with the highest disability and mortality rates in China. Glycosylated hemo-globin (HbA1c) is an established marker of long-term blood glucose control in diabetes patients. The increase of HbA1c is related to the increased risk of cardiovascular events in diabetes patients and non-diabetes patients. This article reviews the physiological and pathological mechanisms, re-lated research, and other aspects of the association between HbA1c and coronary heart disease based on relevant literature in recent years to provide theoretical support for the prevention and treatment of coronary heart disease.
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