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miR-126在调控糖尿病视网膜病变中的研究进展
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Abstract:
糖尿病视网膜病变(DR)是常见的糖尿病并发症，而目前对于DR的治疗中，微小RNA作为在糖尿病视网膜病变的近年热点，microRNA在调控和表达细胞因子上起重要作用，有望成为治疗DR的突破口。MicroRNA-126 (miR-126)在癌症发展，心脏、肾脏及眼中表达均有重要意义。miR-126在眼科中的表达，尤其在视网膜上皮中特异表达，通过多种细胞因子调控内皮细胞增殖，并维持血视网膜屏障，对于糖尿病视网膜病变的过程中的分化、增殖和代谢方面有密切关系。本文通过对miR-126研究现状的实验方法、作用机制展开讨论和总结，旨在思考miR-126是否可为治疗DR提供新思路。
Diabetic retinopathy (DR) is a common complication of diabetes, where microRNA is a hotspot for the treatment in recent years, which plays a significant role in the regulation and expression of cy-tokines, with expectation to become a breakthrough in the treatment of DR. The expression of mi-croRNA-126 (miR-126) is crucial in the development of cancer, heart, kidney and eyes. In Ophthal-mology, especially in retinal epithelium, the expression of miR-126 is regulated by a variety of cyto-kines, manipulating endothelial cell proliferation and maintain blood retinal barrier that is closely related to the diabetic retinopathy process of differentiation, proliferation and metabolism in. In this paper, the experimental methods as well as mechanism of miR-126 research are summarized and discussed, aiming to determine whether miR-126 can provide new approaches for the treat-ment of DR.
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