A prospective and analytical study was
carried out from January 2017 to Decem-ber 2022, at the National Laboratory of
Clinical Biology and Public Health (LNBCSP) in Bangui. 352 samples of
cerebrospinal fluid (CSF) were confirmed out of 2065, coming from the four
hospitals in Bangui. This study aimed to evalu-ate the evolution of antibiotic
sensitivity to strains of Streptococcus pneumoniae. CSF had been collected from
patients who presented with meningeal syndromes. Based on the leukocyte count
(White blood cells ≥ 5 mm3), an aliquot was trans-ferred to trans-isolate medium and
sent to the LNBCSP for confirmatory testing, culture and determination of antibiotic
sensitivity. The antibiotic sensitivity of Streptococcus pneumoniae strains was
tested according to the methods recom-mended by the Antibiogram Committee of
the French Society of Microbiology. The data collected was entered into Excel
2010 to be analyzed with Epi Info 7.2. Ficher’s exact test, chi2 at the 5%
threshold (p < 0.05) was used to compare pro-portions and analyze
associations between variables. The average sensitivity rate to β-lactams was
74.43%. The sensitivity rate of Fluoroquinolones was 54.54%. That of
levofloxacin was 87%. The average rate of sensitivity to β-lactams for the age
group under 5 years old was 79.25%. That of fluoroquinolones was 52.59%.
Levofloxacin had 90.37%. The average sensitivity rate to β-lactams for the age
group over 5 years old was 76.03%. Fluoroquinolones had 45.16%. Levofloxacin
had 69.58%. The average sensitivity rate to β-lactams for males was 76.68%.
Fluoroquinolones had 54.26%. That of levofloxacin was 83.40%. The sensitivity
rate to β-lactams for females was 74.41%. That of fluoroquinolones was 51.16%.
Levofloxacin had 67.44%. Cyclins had 28.68%. The study noted an association
between age and sensitivity (p < 0.05; CI [1.05-2.57]). Strains of
Streptococcus pneumoniae were always detected in the CSF. The average rate of
sensitivity to macrolides was 36.93%; aminoglycosides 28.69%; phenicols 63.35%;
sulfona-mides 39.2%. These results could suggest a reduced sensitivity to β
lactams.
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