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中药调控内质网应激的机制及研究进展
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Abstract:
内质网应激是细胞为了恢复内质网稳定状态维持细胞的生存而产生的一种病理机制，在此过程中会激活多种信号通路，若此时，内质网功能难以自主修复时就会导致细胞自噬或者细胞凋亡，而中药在治疗疾病过程中所发挥的机制防御功能是不可替代的。本文就中药在内质网应激方面的研究进行综述，以阐述中药治疗疾病的新靶点，新途径，为中药的现代化研究提供新的研究思路和方向。
Endoplasmic reticulum stress is a pathological mechanism generated by cells to restore the stable state of the endoplasmic reticulum and maintain the survival of cells. During this process, multiple signal pathways will be activated. If the endoplasmic reticulum function is difficult to repair itself at this time, it will lead to autophagy or apoptosis of cells. The mechanism defense function of Chinese medicine in the treatment of diseases is irreplaceable. In this paper, the research on endoplasmic reticulum stress of Traditional Chinese Medicine (TCM) is reviewed to illustrate the new target and new approach of TCM in treating diseases, and to provide new research ideas and directions for the modernization of TCM.
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