|
|
IgA肾病生物预后预测标志物研究进展
|
Abstract:
IgA肾病是世界范围内发病率最高的原发性肾小球疾病，其临床表现和预后的个体差异极大，因此早期发现影响预后的因素尤为重要。随着对IgAN发病机制的进一步研究，一些新的、更简便的的生物标志物被发现，包括甘油三酯与高密度脂蛋白胆固醇比值(TG/HDL-C)、微小RNA、IgM的沉积、白细胞介素-6、中性粒细胞–淋巴细胞比值(NLR)、血小板与白蛋白比值(PAR)、血小板与淋巴细胞比值(PLR)等，为早期识别、干预高危患者提供了更多的可能性，都可作为IgA肾病预后预测标志物。
IgA nephropathy is the primary glomerular disease with the highest incidence worldwide, and its clinical manifestations and prognosis are characterized by great individual variability, making early detection of factors affecting prognosis particularly important. With further studies on the patho-genesis of IgAN, some new and easier biomarkers have been discovered, including triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C), microRNA, IgM deposition, interleukin-6, neutrophil-lymphocyte ratio (NLR), platelet to albumin ratio (PAR), and platelet-to-lym- phocyte ra-tio (PLR), etc., which provide more possibilities for early identification and intervention in high-risk patients, can all be used as prognostic predictive markers for IgA nephropathy.
| [1] | Rodrigues, J.C., Haas, M. and Reich, H.N. (2017) IgA Nephropathy. Clinical Journal of the American Society of Neph-rology, 12, 677-686. https://doi.org/10.2215/CJN.07420716 |
| [2] | Pei, G., Qin, A., Dong, L., Wang, S., Liu, X., Yang, D., Tan, J., Zhou, X., Tang, Y. and Qin, W. (2022) Prognostic Value of Triglyceride to High-Density Lipoprotein Cholesterol Ratio (TG/HDL-C) in IgA Nephropathy Patients. Frontiers in Endocrinology (Lausanne), 13, Article ID: 877794. https://doi.org/10.3389/fendo.2022.877794 |
| [3] | Nguyen, H.H., Tran, H.H., Nguyen, L.T., Nguyen, T., Nguyen, N.A., Vi, M.T. and Nguyen, K.T. (2022) TG/HDL-C Ratio Is a Risk Factor Associated with CKD: Use in As-sessing the Risk of Progression of CKD. Pathophysiology, 29, 374-382. https://doi.org/10.3390/pathophysiology29030029 |
| [4] | Kant, S., Kronbichler, A., Sharma, P. and Geetha, D. (2022) Advances in Understanding of Pathogenesis and Treatment of Immune-Mediated Kidney Disease: A Review. American Journal of Kidney Diseases, 79, 582-600.
https://doi.org/10.1053/j.ajkd.2021.07.019 |
| [5] | Wada, Y., Matsumoto, K., Suzuki, T., Saito, T., Kanazawa, N., Tachibana, S., Iseri, K., Sugiyama, M., Iyoda, M. and Shibata, T. (2018) Clinical Significance of Serum and Mesangial Galactose-Deficient IgA1 in Patients with IgA Nephropathy. PLOS ONE, 13, e0206865. https://doi.org/10.1371/journal.pone.0206865 |
| [6] | Placzek, W.J., Yanagawa, H., Makita, Y., Renfrow, M.B., Jul-ian, B.A., Rizk, D.V., Suzuki, Y., Novak, J. and Suzuki, H. (2018) Serum Galactose-Deficient-IgA1 and IgG Autoanti-bodies Correlate in Patients with IgA Nephropathy. PLOS ONE, 13, e0190967. https://doi.org/10.1371/journal.pone.0190967 |
| [7] | Tan, L., Tang, Y., Pei, G.Q., Zhong, Z.X., Tan, J.X., Ma, Y., Wang, D.G., Zhou, L., Sheikh-Hamad, D. and Qin, W. (2021) Mesangial IgM Deposition Predicts Renal Outcome in Patients with IgA Nephropathy: A Multicenter, Observational Study. Clinical and Experimental Medicine, 21, 599-610. https://doi.org/10.1007/s10238-021-00703-1 |
| [8] | Xiong, L., Liu, L., Tao, Y. and Guo, H. (2023) Clinical Signifi-cance of IgM and C3 Deposition in Children with Primary Immunoglobulin A Nephropathy. Journal of Nephrology. https://doi.org/10.1007/s40620-023-01724-7 |
| [9] | Jiang, Y., Zan, J., Shi, S., Hou, W., Zhao, W., Zhong, X., Zhou, X., Lv, J. and Zhang, H. (2021) Glomerular C4d Deposition and Kidney Disease Progression in IgA Nephropathy: A Systematic Review and Meta-Analysis. Kidney Medicine, 3, 1014-1021. https://doi.org/10.1016/j.xkme.2021.06.009 |
| [10] | Wu, D., Lei, L., Zhang, H., Yao, X., Chen, Z., Zhang, N., Ni, J., Ling, C., Liu, X. and Chen, X. (2023) Clinical Relevance of Glomerular C4d Deposition in Children with Early IgA Nephropathy or Henoch-Sch？nlein Purpura Nephropathy. Pediatric Nephrology, 38, 431-438. https://doi.org/10.1007/s00467-022-05585-3 |
| [11] | Ramanathan, K. and Padmanabhan, G. (2020) MiRNAs as Po-tential Biomarker of Kidney Diseases: A Review. Cell Biochemistry & Function, 38, 990-1005. https://doi.org/10.1002/cbf.3555 |
| [12] | Qin, W., Chung, A., Huang, X., Meng, X., Hui, D., Yu, C., Sung, J. and Lan, H. (2011) TGF-β/Smad3 Signaling Promotes Renal Fibrosis by Inhibiting miR-29. Journal of the American Society of Nephrology: JASN, 22, 1462-1474.
https://doi.org/10.1681/ASN.2010121308 |
| [13] | Fang, Y., Yu, X., Liu, Y., Kriegel, A., Heng, Y., Xu, X., Liang, M. and Ding, X. (2013) miR-29c Is Downregulated in Renal Interstitial Fibrosis in Humans and Rats and Restored by HIF-α Activation. American Journal of Physiology. Renal Physiology, 304, F1274-F1282. https://doi.org/10.1152/ajprenal.00287.2012 |
| [14] | Hennino, M., Buob, D., Van der Hauwaert, C., Gnemmi, V., Jomaa, Z., Pottier, N., Savary, G., Drumez, E., No？l, C., Cauffiez, C. and Glowacki, F. (2016) miR-21-5p Renal Expres-sion Is Associated with Fibrosis and Renal Survival in Patients with IgA Nephropathy. Scientific Reports, 6, Article No. 27209. https://doi.org/10.1038/srep27209 |
| [15] | Fan, Q., Lu, R., Zhu, M., Yan, Y., Guo, X., Qian, Y., Zhang, L., Dai, H., Ni, Z. and Gu, L. (2019) Serum miR-192 Is Related to Tubulointerstitial Lesion and Short-Term Disease Pro-gression in IgA Nephropathy. Nephron, 142, 195-207.
https://doi.org/10.1159/000497488 |
| [16] | Mizutani, K., Kawakami, K., Horie, K., Fujita, Y., Kameyama, K., Kato, T., Nakane, K., Tsuchiya, T., Yasuda, M., Masunaga, K., et al. (2019) Urinary Exosome as a Potential Biomarker for Uri-nary Tract Infection. Cellular Microbiology, 21, e13020. https://doi.org/10.1111/cmi.13020 |
| [17] | Min, Q.H., Chen, X.M., Zou, Y.Q., Zhang, J., Li, J., Wang, Y., Li, S.Q., Gao, Q.F., Sun, F., Liu, J., et al. (2018) Differential Expression of Urinary Exosomal MicroRNAs in IgA Nephropathy. Journal of Clinical Laboratory Analysis, 32, e22226. https://doi.org/10.1002/jcla.22226 |
| [18] | Feng, Y., Lv, L.L., Wu, W.J., Li, Z.L., Chen, J., Ni, H.F., Zhou, L.T., Tang, T.T., Wang, F.M., Wang, B., et al. (2018) Urinary Exosomes and Exosomal CCL2 mRNA as Biomarkers of Active Histologic Injury in IgA Nephropathy. The American Journal of Pathology, 188, 2542-2552. https://doi.org/10.1016/j.ajpath.2018.07.017 |
| [19] | Li, S., Hao, H., Li, R. and Guo, S. (2022) Urinary Exosomal Mi-croRNAs as New Noninvasive Biomarkers of IgA Nephropathy. The Tohoku Journal of Experimental Medicine, 256, 215-223. https://doi.org/10.1620/tjem.256.215 |
| [20] | Yamada, K., Huang, Z.Q., Raska, M., Reily, C., Anderson, J.C., Suzuki, H., Ueda, H., Moldoveanu, Z., Kiryluk, K., Suzuki, Y., et al. (2017) Inhibition of STAT3 Signaling Reduces IgA1 Autoantigen Production in IgA Nephropathy. Kidney International Reports, 2, 1194-1207. https://doi.org/10.1016/j.ekir.2017.07.002 |
| [21] | Park, C.H., Han, D.S., Jeong, J.Y., Eun, C.S., Yoo, K.S., Jeon, Y.C. and Sohn, J.H. (2016) The Optimal Cut-Off Value of Neutrophil-to-Lymphocyte Ratio for Predicting Prognosis in Adult Patients with Henoch-Sch？nlein Purpura. PLOS ONE, 11, e0153238. https://doi.org/10.1371/journal.pone.0153238 |
| [22] | Nagy, G.R., Kemény, L. and Bata-Cs？rg？, Z. (2017) Neutro-phil-to-Lymphocyte Ratio: A Biomarker for Predicting Systemic Involvement in Adult IgA Vasculitis Patients. Journal of the European Academy of Dermatology and Venereology, 31, 1033-1037. https://doi.org/10.1111/jdv.14176 |
| [23] | Zhao, W.M., Tao, S.M. and Liu, G.L. (2020) Neutrophil-to-Lymphocyte Ratio in Relation to the Risk of All-Cause Mortality and Cardiovascular Events in Patients with Chronic Kidney Disease: A Systematic Review and Meta-Analysis. Renal Failure, 42, 1059-1066. https://doi.org/10.1080/0886022X.2020.1832521 |
| [24] | Zhang, J., Zhang, R., Wang, Y., Wu, Y., Li, H., Han, Q., Guo, R., Wang, T., Wang, J., Grung, P. and Liu, F. (2019) Effects of Neutrophil-Lymphocyte Ratio on Renal Function and Histologic Lesions in Patients with Diabetic Nephropathy. Nephrology (Carlton), 24, 1115-1121. https://doi.org/10.1111/nep.13517 |
| [25] | Shao, Y., Wu, B., Jia, W., Zhang, Z., Chen, Q. and Wang, D. (2020) Prognostic Value of Pretreatment Neutrophil-to- Lymphocyte Ratio in Renal Cell Carcinoma: A Systematic Review and Meta-Analysis. BMC Urology, 20, Article No. 90. https://doi.org/10.1186/s12894-020-00665-8 |
| [26] | Ao, G., Wang, Y., Qi, X., Wang, F. and Wen, H. (2021) Association of Neutrophil-to-Lymphocyte Ratio and Risk of Cardio-vascular or All-Cause Mortality in Chronic Kidney Disease: A Meta-Analysis. Clinical and Experimental Nephrology, 25, 157-165. https://doi.org/10.1007/s10157-020-01975-9 |
| [27] | Simonaggio, A., Elaidi, R., Fournier, L., Fabre, E., Ferrari, V., Borchiellini, D., Thouvenin, J., Barthelemy, P., Thibault, C., Tartour, E., et al. (2020) Variation in Neutrophil to Lymphocyte Ratio (NLR) as Predictor of Outcomes in Metastatic Renal Cell Carcinoma (mRCC) and Non-Small Cell Lung Cancer (mNSCLC) Patients Treated with Nivolumab. Cancer Immunology, Immunotherapy, 69, 2513-2522. https://doi.org/10.1007/s00262-020-02637-1 |
| [28] | Wang, S., Dong, L., Pei, G., Jiang, Z., Qin, A., Tan, J., Tang, Y. and Qin, W. (2021) High Neutrophil-to-Lymphocyte Ratio Is an Independent Risk Factor for End Stage Renal Diseases in IgA Nephropathy. Frontiers in Immunology, 12, Article ID: 700224. https://doi.org/10.3389/fimmu.2021.700224 |
| [29] | Li, Q., Chen, P., Shi, S., Liu, L., Lv, J., Zhu, L. and Zhang, H. (2020) Neutrophil-to-Lymphocyte Ratio as an Independent Inflammatory Indicator of Poor Prognosis in IgA Nephropa-thy. International Immunopharmacology, 87, Article ID: 106811. https://doi.org/10.1016/j.intimp.2020.106811 |
| [30] | Holinstat, M. (2017) Normal Platelet Function. Cancer and Me-tastasis Reviews, 36, 195-198.
https://doi.org/10.1007/s10555-017-9677-x |
| [31] | Kumarasamy, C., Tiwary, V., Sunil, K., Suresh, D., Shetty, S., Muthukaliannan, G.K., Baxi, S. and Jayaraj, R. (2021) Prognostic Utility of Platelet-Lymphocyte Ratio, Neutro-phil-Lymphocyte Ratio and Monocyte-Lymphocyte Ratio in Head and Neck Cancers: A Detailed PRISMA Compliant Systematic Review and Meta-Analysis. Cancers (Basel), 13, Article No. 4166. https://doi.org/10.3390/cancers13164166 |
| [32] | Li, L., Yu, J. and Zhou, Z. (2021) Platelet-Associated Parameters in Patients with Psoriasis: A PRISMA-Compliant Systematic Review and Meta-Analysis. Medicine (Baltimore), 100, e28234.
https://doi.org/10.1097/MD.0000000000028234 |
| [33] | Li, L.Q., Bai, Z.H., Zhang, L.H., Zhang, Y., Lu, X.C., Zhang, Y., Liu, Y.K., Wen, J. and Li, J.Z. (2020) Meta-Analysis of Hematological Biomarkers as Reliable Indicators of Soft Tissue Sarcoma Prognosis. Frontiers in Oncology, 10, Article No. 30. https://doi.org/10.3389/fonc.2020.00030 |
| [34] | Chang, D., Cheng, Y., Luo, R., Zhang, C., Zuo, M., Xu, Y., Dai, W., Li, Y., Han, M., He, X., et al. (2021) The Prognostic Value of Platelet-to-Lymphocyte Ratio on the Long-Term Renal Survival in Patients with IgA Nephropathy. International Urology and Nephrology, 53, 523-530. https://doi.org/10.1007/s11255-020-02651-3 |
| [35] | Tan, J., Song, G., Wang, S., Dong, L., Liu, X., Jiang, Z., Qin, A., Tang, Y. and Qin, W. (2022) Platelet-to-Albumin Ratio: A Novel IgA Nephropathy Prognosis Predictor. Frontiers in Immunology, 13, Article ID: 842362.
https://doi.org/10.3389/fimmu.2022.842362 |
