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慢性腰痛患者的脑静息态功能磁共振研究进展
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Abstract:
慢性腰痛(CLBP)是一种常见的健康问题，可发生在所有年龄段的人群中，影响着全球数以百万计的人。但目前关于慢性腰痛的神经病理学机制尚不明确。近年来，脑静息态功能磁共振成像(RS-fMRI)作为一种无创、非侵入性的神经影像学技术，受到越来越多的关注，并被广泛应用于研究CLBP患者的脑神经活动。RS-fMRI使我们能够在网络水平上研究慢性疼痛的病理生理机制，而机器学习使我们能够识别患者的大脑特征并进行准确分类，二者结合常应用于疾病的诊断、分类和预后等方面。虽然国内外对慢性疼痛引起大脑功能的改变做出了一定的研究，但对慢性腰痛引起脑功能的改变仍没有统一定论，本文就目前脑静息态功能磁共振在慢性腰痛患者中的研究进展作一综述。
Chronic low back pain (CLBP) is a common health problem that can occur in people of all ages and affects millions of people worldwide. However, there is a lack of clarity regarding the neuropatho-logic mechanisms of chronic low back pain. In recent years, brain resting-state functional magnetic resonance imaging (RS-fMRI), a noninvasive and noninvasive neuroimaging technique, has received increasing attention and has been widely used to study the brain neural activity of patients with CLBP. RS-fMRI allows us to study the pathophysiological mechanisms of chronic pain at the network level, while machine learning enables us to recognize patients’ brain features and perform an accu-rate classification, and the combination of the two is often applied to the diagnosis, classification and prognosis of diseases. Although some research has been done both at home and abroad on the changes in brain function caused by chronic pain, there is still no unified conclusion on the changes in brain function caused by chronic low back pain. In this paper, we present a review of the current progress of the study of brain resting state functional magnetic resonance in patients with chronic low back pain.
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