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乙肝肝硬化、慢性乙肝患者相关生化指标差异对比研究
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Abstract:
目的：对比分析乙肝肝硬化、慢性乙肝患者相关生化指标差异。方法：回顾分析我院2021年1月~2022年12月我院收治43例乙肝肝硬化(乙肝肝硬化组)和慢性乙肝(慢性乙肝组)患者的临床检查资料，对比两组血常规、生化指标、凝血指标和肿瘤标志物检测结果。结果：乙肝肝硬化组的白细胞计数明显高于慢性乙肝组(P > 0.05)，丙转氨酶、谷草转氨酶、直接胆红素、总胆红素、胱抑素C及总胆汁酸、活化部分凝血活酶时间、凝血酶时间、凝血酶原时间和D-二聚体、甲胎蛋白、癌胚抗原和糖链抗原125均明显高于慢性乙肝组，血红蛋白和血小板计数、白蛋白和肾小球滤过率及纤维蛋白原明显低于慢性乙肝组(P < 0.05)。结论：通过检测明确血常规、生化指标、凝血指标、肿瘤标志物差异，能够诊断乙肝肝硬化、慢性乙肝，利于临床尽早开展乙肝肝硬化防治措施，延缓病情进展，降低癌变风险。
Objective: To compare and analyze the differences of biochemical indexes in patients with hepatitis B cirrhosis and chronic hepatitis B. Methods: The clinical examination data of 43 patients with hep-atitis B cirrhosis (hepatitis B cirrhosis group) and chronic hepatitis B (chronic hepatitis B group) admitted to our hospital from January 2021 to December 2022 were retrospectively analyzed, and the blood routine, biochemical indexes, coagulation indexes and tumor markers were compared between the two groups. Result: The WBC count in hepatitis B cirrhosis group was significantly higher than that in chronic hepatitis B group (P > 0.05), and the pyruvic transaminase, glutamic ox-alacetic transaminase, direct bilirubin, total bilirubin, cystatin C and total bile acid, activated partial thromboplastin time, thrombin time, prothrombin time, D-dimer, alpha-fetoprotein, carcinoem-bryonic antigen and glycochain antigen 125 were significantly higher than those in chronic hepati-tis B group. Hemoglobin and platelet count, albumin and glomerular filtration rate and fibrinogen were significantly lower than those in chronic hepatitis B group (P < 0.05). Conclusion: The differ-ences in blood routine, biochemical indexes, coagulation indexes and tumor markers can diagnose hepatitis B cirrhosis and chronic hepatitis B, which is conducive to clinical prevention and treat-ment of hepatitis B cirrhosis as early as possible, delay the progression of the disease and reduce the risk of cancer.
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