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从红系发育角度探讨高原红细胞增多症发病机制
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Abstract:
高原红细胞增多症(HAPC, high altitude polycythemia)是由高原低氧引起的以红细胞过度生成为主要表现的病症，该病发病机制复杂，现代医学、藏医学及中医学对HAPC有大量的研究，主要围绕流行病学，细胞生物学及分子生物学方面，但研究方向比较分散，且药物方面的研究明显不足，所以目前对该病的治疗仍然没有系统的认识，因此本文对HAPC的现代研究进行系统的归纳总结，主要包括影响红细胞生成过程中的影响因子，信号通路及低氧条件下红细胞的损伤，为HAPC的机制研究提供方向，以期为中西医的治疗方案提供理论基础。
High altitude polycythemia (HAPC) is a disease caused by low oxygen at high altitude and mainly manifested by excessive production of red blood cells. Due to the complex pathogenesis of this dis-ease, modern medicine, Tibetan medicine and traditional Chinese medicine have conducted a large number of studies on HAPC, mainly focusing on epidemiology. In terms of cell biology and molecular biology, the research direction is relatively scattered, and the research on drugs is obviously insuf-ficient, so there is still no systematic understanding of the treatment of this disease. Therefore, this paper systematically summarizes the modern research on HAPC, mainly including the influencing factors in the process of erythropoiesis, signaling pathways, and damage of red blood cells under hypoxia conditions. To provide a direction for the study of the mechanism of HAPC, in order to pro-vide a theoretical basis for traditional Chinese and western medicine treatment.
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