Introduction: SARS-COV-2 infection is a real public health challenge for the World Health Organization and for our country. It is responsible for numerous hematological abnormalities in infected patients. Objectives: To describe the haemogram abnormalities in patients infected with SARS-COV-2 and to determine which ones are associated with death. Material and Method: We conducted a retrospective, descriptive, analytical, cross-sectional study from March 2020 to September 2021. The study included all patients hospitalized with RT-PCR-confirmed COVID-19 who performed a blood count. We evaluated the blood count profile, the pathologies found and the associated blood count abnormalities. Results: A total of 263 patients were included. The mean age of the patients was 63.77 years (range 12 - 90 years). The male sex represented 54.75% (n = 144) while the female sex was 45.25% (n = 119) (sex ratio = 1.21). The most common pathologies were: diabetes: 30.03% (n = 79), high blood pressure: 41.04% (n = 108), and Chronic kidney disease: 7.98 (n = 21). The abnormalities of the haemogram found were essential: anaemia 28.13% (n = 121), hyperleukocytosis with neutrophilic predominance: 29.3% (126), lymphopenia: 34.41% (n = 148), thrombocytopenia: 8.16% (n = 35). The search for hematological factors associated with death in patients showed a significant difference between hyperleukocytosis (p = 0.000) and lymphopenia (p = 0.0001). Conclusion: SARS-COV-2 disease was a mortality factor when associated with lymphopenia and hyperleukocytosis in our series.
References
[1]
Frimousse, S. and Peretti, J.M. (2020) Organizational Changes Induced by the Covid-19 Crisis. Questions de Management, 3, 105-149. https://doi.org/10.3917/qdm.203.0105
[2]
Defraigne, J.C. (2020) The Geoeconomic Impact of Covid-19 on the Globalized Economy. Outre-Terre, 57, 23-46. https://doi.org/10.3917/oute2.057.0023
[3]
World Health Organization (WHO) (2022) Public Health Surveillance in the Context of COVID-19: Interim Guidance. 22 July 2022. https://www.who.int/publications/i/item/WHO-2019-nCoV-SurveillanceGuidance-2022.2
[4]
Kaeuffer, C., Le Hyaric, C., Fabacher, T., Mootien, J., Ruch, Y., Zhu, Y.J., et al. (2020) Clinical Features and Risk Factors Associated with Severe Forms of COVID-19: A Prospective Multicenter Analysis of 1045 Cases. Médecine et Maladies Infectieuses, 50, S27. https://doi.org/10.1016/j.medmal.2020.06.440
[5]
Plaçais, L. and Richier, Q. (2020) COVID-19: Clinical, Biological and Radiological Characteristics in Adults, Pregnant Women and Children. An Update in the Midst of the Pandemic. La Revue de Médecine Interne, 41, 308-318. https://doi.org/10.1016/j.revmed.2020.04.004
[6]
Osman, M., Safer, M., Hechaichi, A., Letaief, H., Dhaouadi, S., Harizi, C., et al. (2019) Predictive Factors of Covid-19 Mortality: Review of the Literature. https://www.onmne.tn/wp-content/uploads/2020/10/Facteurs-de-mortalite-COVID-19_HBS_8_10_2020.pdf
[7]
Violetis, O.A., Chasouraki, A.M., Giannou, A.M. and Baraboutis, I.G. (2020) COVID-19 Infection and Haematological Involvement: A Review of Epidemiology, Pathophysiology and Prognosis of Full Blood Count Findings. SN Comprehensive Clinical Medicine, 2, 1089-1093. https://doi.org/10.1007/s42399-020-00380-3
[8]
Toba, N., Gupta, S., Ali, A.Y., ElSaban, M., Khamis, A.H., Ho, S.B., et al. (2021) COVID-19 under 19: A Meta-Analysis. Pediatric Pulmonology, 56, 1332-1341. https://doi.org/10.1002/ppul.25312
[9]
Agbuduwe, C. and Basu, S. (2020) Haematological Manifestations of COVID-19: From Cytopenia to Coagulopathy. European Journal of Haematology, 105, 540-546. https://doi.org/10.1111/ejh.13491
[10]
Rahman, M.A., et al. (2022) Hematological Abnormalities and Comorbidities Are Associated with COVID-19 Severity among Hospitalized Patients: Experience from Bangladesh. PLOS ONE, 16, e0255379. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0255379
[11]
Chen, X., Yan, L., Fei, Y. and Zhang, C. (2020) Laboratory Abnormalities and Risk Factors Associated with In-Hospital Death in Patients with Severe COVID-19. Journal of Clinical Laboratory Analysis, 34, e23467. https://doi.org/10.1002/jcla.23467
[12]
Daoui, M.A. (2021) Epidemiological, Clinical and Biological Profile of COVID-19 Patients Hospitalized at the Hassan II CHR in Agadir. http://wd.fmpm.uca.ma/biblio/theses/annee-htm/FT/2021/these138-21.pdf
[13]
Taj, S., Fatima, S.A., Imran, S., Lone, A. and Ahmed, Q. (2021) Role of Hematological Parameters in the Stratification of COVID-19 Disease Severity. Annals of Medicine and Surgery, 62, 68-72. https://doi.org/10.1016/j.amsu.2020.12.035
[14]
Diallo, K., Thioubou, M.A., Wembulua, B.S., Kane, Y. and Coly, M.N. (2021) COVID-19: Experience of the Epidemic Treatment Center of Ziguinchor, Southern Region of Senegal. Journal of Infectious Diseases and Epidemiology, 7, Article 216.
[15]
Diop, M., Ba, P.S., Moustapha, L., et al. (2021) Factors Associated with Severe COVID-19 in an Epidemic Treatment Center at Dakar. Journal of Infectious Diseases and Epidemiology, 7, 2474-3658. https://doi.org/10.23937/2474-3658/1510203
[16]
Faye, F.A., Berthe, A., Lawson, T.A.D., et al. (2021) Mise en place d’un centre de traitement des épidémies (CTE) pour Covid-19 dans un service de Médecine Interne; Les leçonsapprises. Revue Africaine de Médecine Interne, 8, 32-36.
[17]
Angelo, A.C., Clodel, Y., Léopold, C., Serge, A., Ibrahim, M.C., Julien, A., et al. (2023) Epidemiological, Clinical, Therapeutic Features and Predictors of Death among COVID-19 Patients Hospitalized in Parakou: A Cross-Sectional Study in Northern Benin. BMC Infectious Diseases, 23, Article No. 484. https://doi.org/10.1186/s12879-023-08445-z
[18]
Yang, X., et al. (2020) Clinical Course and Outcomes of Critically Ill Patients with SARS-CoV-2 Pneumonia in Wuhan, China: A Single-Centered, Retrospective, Observational Study. The Lancet Respiratory Medicine, 8, 475-481. https://doi.org/10.1016/S2213-2600(20)30079-5
[19]
Zhou, F., et al. (2020) Clinical Course and Risk Factors for Mortality of Adult Inpatients with COVID-19 in Wuhan, China: A Retrospective Cohort Study. The Lancet, 395, 1054-1062. https://doi.org/10.1016/S0140-6736(20)30566-3
[20]
Wu, C.M., Chen, X.Y., Cai, Y.P., et al. (2020) Risk Factors Associated with Acute Respiratory Distress Syndrome and Death in Patients with Coronavirus Disease 2019 Pneumonia in Wuhan, China. JAMA Internal Medicine, 180, 934-943. https://doi.org/10.1001/jamainternmed.2020.0994
[21]
Guan, W., Ni, Z., Hu, Y., Liang, W., Ou, C., et al. (2020) Clinical Characteristics of Corona-Virus Disease 2019 in China. The New England Journal of Medicine, 382, 1708-1720. https://doi.org/10.1056/NEJMoa2002032
[22]
World Health Organization (2021) WHO Coronavirus (COVID-19) Dashboard. https://covid19.who.int/
[23]
Zhou, F., Yu, T., Du, R.H., Fan, G.H., Liu, Y., Liu, Z.B., et al. (2020) Clinical Course an Risk Factors for Mortality of Adult Inpatients with COVID-19 in Wuhan, China: A Retrospective Cohort Study. The Lancet, 3959, 1054-1062. https://doi.org/10.1016/S0140-6736(20)30566-3
[24]
Goyal, P., Choi, J.J., Pinheiro, L.C., et al. (2020) Clinical Characteristics of Covid-19 in New York City. The New England Journal of Medicine, 382, 2372-2374. https://doi.org/10.1056/NEJMc2010419
[25]
Faye, A., Ndao, A., Diagne, N., et al. (2022) The COVID-19 Pandemic in Senegal: Experience of an Internal Medicine Department as an Epidemic Treatment Center. Open Journal of Internal Medicine, 12, 13-21. https://doi.org/10.4236/ojim.2022.121002
[26]
Sun, S., Cai, X., Wang, H., He, G., Lin, Y., Lu, B., et al. (2020) Abnormalities of Peripheral Blood System in Patients with COVID-19 in Wenzhou, China. Clinica Chimica Acta, 507, 174-180. https://doi.org/10.1016/j.cca.2020.04.024
[27]
Rahman, A., Niloofa, R., Jayarajah, U., De Mel, S., Abeysuriya, V. and Seneviratne, S.L. (2021) Hema-Tological Abnormalities in COVID-19: A Narrative Review. The American Journal of Tropical Medicine and Hygiene, 104, 1188-1201. https://doi.org/10.4269/ajtmh.20-1536
[28]
Lucijanic, M., Krecak, I., Soric, E., Sedinic, M., Sabljic, A., Derek, L., et al. (2021) Thrombocytosis in COVID-19 Patients without Myeloproliferative Neoplasms Is Associated with a Better Prognosis but a Higher Rate of Venous Thromboembolism. Blood Cancer Journal, 11, Article No. 189. https://doi.org/10.1038/s41408-021-00585-2
[29]
Lindsley, A.W., Schwartz, J.T. and Rothenberg, M.E. (2020) Eosinophil Responses during COVID-19 Infections and Coronavirus Vaccination. Journal of Allergy and Clinical Immunology, 146, 1-7. https://doi.org/10.1016/j.jaci.2020.04.021
[30]
Yarali, N., Akcabelen, Y.M., Unal, Y. and Parlakay, A.N. (2021) Hematological Parameters and Morphological Abnormalities of Peripheral Blood in Children with COVID-19. Pediatric Blood & Cancer, 68, e28596. https://doi.org/10.22541/au.159069193.34265275
[31]
Bellan, M., Azzolina, D., Hayden, E., Gaidano, G., Pirisi, M., Acquaviva, A., et al. (2021) Simple Parameters from Complete Blood Count Predict In-Hospital Mortality in COVID-19. Disease Markers, 2021, e8863053.
