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Th17.1细胞与系统性红斑狼疮发病机制的研究进展
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Abstract:
系统性红斑狼疮(Systemic lupus erythematosus, SLE)是一种慢性、累及多系统多器官的、自身免疫性疾病，可致重要脏器损害，诊断不及时或治疗不当可危及患者生命。其病因是多种因素综合作用的结果，包括遗传、环境、雌激素、免疫耐受的破坏等导致T、B免疫细胞功能亢进、多种自身抗体生成、炎性细胞因子及免疫调节功能失衡等。而辅助性T (T helper, Th)细胞17.1是最近发现的簇分化抗原(Cluster of differentiation, CD) 4+T细胞功能亚群，探明Th17.1细胞在SLE组织器官中的分布和功能，揭示Th17.1细胞参与SLE发病及靶器官损伤的通路和机制是有必要的，以期为SLE疾病预防、病情评估以及开发精准个体化治疗靶点提供理论依据并指明新方向。
Systemic lupus erythematosus is a chronic, multi-system and multi-organ, autoimmune disease that usually occurs in women between adolescence and menopause, and clinical manifestations are di-verse, with significant heterogeneity. SLE is a serious disease that can cause damage to important organs. Delayed diagnosis or improper treatment may endanger patients’ lives. The combined ef-fects of various factors, including the destruction of genetics, environment, estrogen and immune tolerance, lead to hyperfunction of T and B immune cells, the generation of various autoantibodies, inflammatory cytokines and the imbalance of immune regulatory function, which cause the disor-der of immune system and trigger the onset of SLE. Helper T cell 17.1 is a functional subgroup of cluster differentiation antigen 4+T cells recently discovered. The distribution and function of Th17.1 cells in SLE tissues and organs have been explored, and the pathway and mechanism of Th17.1 cells involved in SLE pathogenesis and target organ injury have been revealed, in order to provide theo-retical basis and point out new direction for SLE disease prevention, disease assessment and the development of accurate individualized therapeutic targets.
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