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靶向有氧糖酵解途径治疗卵巢癌的研究进展
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Abstract:
卵巢癌是是妇产科死亡较高的恶性肿瘤之一，其疾病多数快速进展及隐匿，给患者和医生们带来了巨大的困扰；有氧糖酵解是指肿瘤即使在氧气充足的情况下，依然偏好于糖酵解进行物质代谢产生能量，为肿瘤快速生长及繁殖提供条件；因此，如果能对肿瘤的这种代谢重编程进行靶向阻遏，就有可能阻断肿瘤细胞生长复制，并提高药物对肿瘤的敏感性，故靶向阻断有氧糖酵解可能是一种有前景的治疗策略，本文将针对卵巢癌糖酵解途径治疗的研究进展进行概述。
Ovarian cancer is one of the malignant tumors with a high mortality rate in obstetrics and gynecology, and most of its diseases are rapidly progressing and hidden, causing great distress to patients and doctors; aerobic glycolysis refers to the preference of tumors for glycolysis to metabolize substances and generate energy even when oxygen is sufficient, providing conditions for rapid growth and reproduction of tumors; therefore, if targeted inhibition of the metabolic reprogramming of tumors can be carried out, it is possible to block the growth and replication of tumor cells and improve the sensitivity of drugs to tumors. Therefore, targeted blockade of aerobic glycolysis may be a promising treatment strategy. This article will provide an overview of the research progress in the treatment of ovarian cancer through the glycolysis pathway.
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