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中药逆转鲍曼不动杆菌耐药性研究进展
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Abstract:
耐药鲍曼不动杆菌感染是备受关注的临床问题，目前可供选择的敏感抗菌药物品种有限，且新型抗菌药物的研发难以满足临床迫切需求。中药凭借其药源广、多靶点的独特优势被广泛应用于抗感染治疗，在协同抗菌及逆转细菌耐药性方面表现出较好的发展潜力。文章总结了鲍曼不动杆菌常见耐药机制，从单味中药、中药单体、中药颗粒及中药复方制剂等不同中药制剂的角度综述中药逆转鲍曼不动杆菌耐药性的研究进展，重点阐述了部分中药在逆转细菌耐药性方面的确切疗效及作用机制并且分析了当前研究的局限性和未来探索的要点，以期为耐药细菌感染的相关研究及临床治疗提供新的思路及理论依据。
The infection of drug resistant Acinetobacter baumannii is a highly concerned problem in clinical practice. On one hand, there are a limited number of sensitive antimicrobial agents available; on the other hand, the development of new antibacterial drugs is difficult to meet the urgent clinical need. Thanks to its unique advantages of extensive resources and multiple acting targets, tradi-tional Chinese medicine has been widely used in the field of anti-infective treatment. It shows out-standing development potential in the synergistic antibacterial therapy and the reversal of bacteri-al resistance. This paper summarizes the common mechanisms of drug resistance in Acinetobacter baumannii, and reviews the research progress of reversing drug resistance in Acinetobacter bau-mannii by traditional Chinese medicine (TCM) from the perspective of single TCM, TCM monomer, TCM granule as well as TCM compound preparation. In addition, this paper focuses on elaborating on the reliable efficacies with explicit mechanisms of some traditional Chinese medicines in revers-ing bacterial resistance, and then it analyzes the limitations of current researches with the key points in future exploration. This study is expected to provide new ideas and theoretical basis for the researches and clinical treatments of the infection related to drug-resistant bacterial.
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