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辅助生殖技术相关母婴风险研究进展
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Abstract:
近年来，辅助生殖技术(assisted reproductive technology, ART)蓬勃发展并日益成熟，成为治疗不孕症的主要手段。过去，生殖领域专家关注如何提高临床妊娠率和累计活产率。但ART过程中一些非生理性的干预，如超生理剂量的激素类药物使用，可能会对母婴结局造成不利影响。这些不良结局似乎与多胎妊娠率高有关，单胚胎移植可最大限度降低风险。目前，ART相关并发症发生率与ART有关还是与不孕症本身有关尚存争议。本文的目的是综述近年来辅助生殖技术相关妊娠期并发症和新生儿出生结局相关文献。
In recent years, assisted reproductive technology (ART) has flourished and become increasingly sophisticated as a primary treatment for infertility. In the past, specialists in the field of reproduc-tion have focused on improving clinical pregnancy rates and cumulative live birth rates. However, some non-physiological interventions during ART, such as the use of super physiological doses hormone drugs, may adversely affect maternal and infant outcomes. These adverse outcomes ap-pear to be associated with high rates of multiple pregnancies, with single embryo transfer mini-mizing the risk. It is controversial whether the rate of ART-related complications is related to ART or to infertility itself. The purpose of this article is to review the literature related to pregnancy complications and neonatal birth outcomes associated with assisted reproductive technologies in recent years.
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