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ADAMTS-13调控急性心肌梗死的机制研究
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Abstract:
ADAMTS-13是一种金属蛋白酶，可特异性切割血管性血友病因子(VWF)，从而防止白细胞过度募集，下调炎症和血栓的形成。ADAMTS-13与VWF现在被认为在越来越多的血管炎症和血栓形成的疾病中起重要作用，特别是在急性心肌梗死(AMI)中研究越来越深入。ADAMTS-13结构与功能和AMI发生机制密切相关。本篇综述主要阐述ADAMTS-13调控AMI的作用机制。
ADAMTS-13 is a metalloproteinase secreted in the blood that can specifically cleave von Willebrand Factor (VWF), thereby preventing excessive recruitment of white blood cells and downregulating inflammation and thrombosis formation. ADAMTS-13 and VWF are now considered to play an im-portant role in an increasing number of vascular inflammation and thrombosis diseases, especially in the study of acute myocardial infarction (AMI). The structure and function of ADAMTS-13 are closely related to the mechanism of AMI occurrence. This review mainly elaborates on the mecha-nism of ADAMTS-13 in regulating acute myocardial infarction.
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